- Spatial organization of transmembrane receptor signalling
[作者：Bethani, I; Skanland, SS; Dikic, I; Acker-Palmer, A,期刊：EMBO journal, 页码：2677-2688 , 文章类型： Review，,卷期：2010年29-16]
- The spatial organization of transmembrane receptors is a critical step in signal transduction and receptor trafficking in cells. Transmembrane receptors engage in lateral homotypic and heterotypic cis-interactions as wel...
- Spatial cycles in G-protein crowd control
[作者：Vartak, N; Bastiaens, P,期刊：EMBO journal, 页码：2689-2699 , 文章类型： Review，,卷期：2010年29-16]
- The nature of living systems and their apparent resilience to the second law of thermodynamics has been the subject of extensive investigation and imaginative speculation. The segregation and compartmentalization of prot...
- Spatial organization in bacterial chemotaxis
[作者：Sourjik, V; Armitage, JP,期刊：EMBO journal, 页码：2724-2733 , 文章类型： Review，,卷期：2010年29-16]
- Spatial organization of signalling is not an exclusive property of eukaryotic cells. Despite the fact that bacterial signalling pathways are generally simpler than those in eukaryotes, there are several well-documented e...
- Cellular responses to extracellular guidance cues
[作者：Berzat, A; Hall, A,期刊：EMBO journal, 页码：2734-2745 , 文章类型： Review，,卷期：2010年29-16]
- Extracellular guidance cues have a key role in orchestrating cell behaviour. They can take many forms, including soluble and cell-bound ligands (proteins, lipids, peptides or small molecules) and insoluble matrix substra...
- Protein homeostasis and synaptic plasticity
[作者：Cajigas, IJ; Will, T; Schuman, EM,期刊：EMBO journal, 页码：2746-2752 , 文章类型： Review，,卷期：2010年29-16]
- It is clear that de novo protein synthesis has an important function in synaptic transmission and plasticity. A substantial amount of work has shown that mRNA translation in the hippocampus is spatially controlled and th...
- Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex
[作者：Halls, ML; Cooper, DMF,期刊：EMBO journal, 页码：2772-2787 , 文章类型： Article，,卷期：2010年29-16]
- Biochemical studies suggest that G-protein-coupled receptors (GPCRs) achieve exquisite signalling specificity by forming selective complexes, termed signalosomes. Here, using cAMP biosensors in single cells, we uncover a...
- Molecular steps of G-overhang generation at human telomeres and its function in chromosome end protection
[作者：Dai, XY; Huang, CH; Bhusari, A; Sampathi, S; Schubert, K; Chai, WH,期刊：EMBO journal, 页码：2788-2801 , 文章类型： Article，,卷期：2010年29-16]
- Telomeric G-overhangs are required for the formation of the protective telomere structure and telomerase action. However, the mechanism controlling G-overhang generation at human telomeres is poorly understood. Here, we ...
- 14-3-3 gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage
[作者：Kasahara, K; Goto, H; Enomoto, M; Tomono, Y; Kiyono, T; Inagaki, M,期刊：EMBO journal, 页码：2802-2812 , 文章类型： Article，,卷期：2010年29-16]
- 14-3-3 proteins control various cellular processes, including cell cycle progression and DNA damage checkpoint. At the DNA damage checkpoint, some subtypes of 14-3-3 (beta and zeta isoforms in mammalian cells and Rad24 i...
- AGAP1/AP-3-dependent endocytic recycling of M-5 muscarinic receptors promotes dopamine release
[作者：Bendor, J; Lizardi-Ortiz, JE; Westphalen, RI; Brandstetter, M; Hemmings, HC; Sulzer, D; Flajolet, M; Greengard, P,期刊：EMBO journal, 页码：2813-2826 , 文章类型： Article，,卷期：2010年29-16]
- Of the five mammalian muscarinic acetylcholine (ACh) receptors, M-5 is the only subtype expressed in midbrain dopaminergic neurons, where it functions to potentiate dopamine release. We have identified a direct physical ...
- PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression
[作者：Jurado, S; Benoist, M; Lario, A; Knafo, S; Petrok, CN; Esteban, JA,期刊：EMBO journal, 页码：2827-2840 , 文章类型： Article，,卷期：2010年29-16]
- Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is an important regulator of phosphatidylinositol-(3,4,5,)-trisphosphate signalling, which controls cell growth and differentiation. However, PTEN is also h...
- ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
[作者：Dormann, D; Rodde, R; Edbauer, D; Bentmann, E; Fischer, I; Hruscha, A; Than, ME; Mackenzie, IRA; Capell, A; Schmid, B; Neumann, M; Haass, C,期刊：EMBO journal, 页码：2841-2857 , 文章类型： Article，,卷期：2010年29-16]
- Mutations in fused in sarcoma (FUS) are a cause of familial amyotrophic lateral sclerosis (fALS). Patients carrying point mutations in the C-terminus of FUS show neuronal cytoplasmic FUS-positive inclusions, whereas in h...
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