- Natural killer T cell-a cat o ' nine lives!
[作者：Joyce, S; Gordy, LE,期刊：EMBO journal, 页码：1475-1476 , 文章类型： Article，,卷期：2010年29-9]
- The cylindromatous gene Cyld encodes a deubiquitylase (DUB), which regulates NF-kappa B activation. CYLD deficiency results in faulty innate and adaptive immune systems in mice, the basis for which remains incompletely u...
- Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function
[作者：Manford, A; Xia, T; Saxena, AK; Stefan, C; Hu, FH; Emr, SD; Mao, YX,期刊：EMBO journal, 页码：1489-1498 , 文章类型： Article，,卷期：2010年29-9]
Sac family phosphoinositide (PI) phosphatases are an essential family of CX5R(T/S)-based enzymes, involved in numerous aspects of cellular function such as PI homeostasis, cellular signalling, and membrane trafficking...
- USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly
[作者：Theard, D; Labarrade, F; Partisani, M; Milanini, J; Sakagami, H; Fon, EA; Wood, SA; Franco, M; Luton, F,期刊：EMBO journal, 页码：1499-1509 , 文章类型： Article，,卷期：2010年29-9]
- In epithelial cells, the tight junction (TJ) functions as a permeability barrier and is involved in cellular differentiation and proliferation. Although many TJ proteins have been characterized, little is known about the...
- JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation
[作者：Tanaka, Y; Okamoto, K; Teye, K; Umata, T; Yamagiwa, N; Suto, Y; Zhang, Y; Tsuneoka, M,期刊：EMBO journal, 页码：1510-1522 , 文章类型： Article，,卷期：2010年29-9]
- The rate-limiting step in ribosome biogenesis is the transcription of ribosomal RNA, which is controlled by environmental conditions. The JmjC enzyme KDM2A/JHDM1A/FbxL11 demethylates mono-and dimethylated Lys 36 of histo...
- TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends
[作者：Bombarde, O; Boby, C; Gomez, D; Frit, P; Giraud-Panis, MJ; Gilson, E; Salles, B; Calsou, P,期刊：EMBO journal, 页码：1573-1584 , 文章类型： Article，,卷期：2010年29-9]
- DNA-dependent protein kinase (DNA-PK) is a double-strand breaks repair complex, the subunits of which (KU and DNA-PKcs) are paradoxically present at mammalian telomeres. Telomere fusion has been reported in cells lacking...
- AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX
[作者：Artus, C; Boujrad, H; Bouharrour, A; Brunelle, MN; Hoos, S; Yuste, VJ; Lenormand, P; Rousselle, JC; Namane, A; England, P; Lorenzo, HK; Susin, SA,期刊：EMBO journal, 页码：1585-1599 , 文章类型： Article，,卷期：2010年29-9]
- Programmed necrosis induced by DNA alkylating agents, such as MNNG, is a caspase-independent mode of cell death mediated by apoptosis-inducing factor (AIF). After poly(ADP-ribose) polymerase 1, calpain, and Bax activatio...
- Regulation of natural killer T-cell development by deubiquitinase CYLD
[作者：Lee, AJ; Zhou, XF; Chang, M; Hunzeker, J; Bonneau, RH; Zhou, DP; Sun, SC,期刊：EMBO journal, 页码：1600-1612 , 文章类型： Article，,卷期：2010年29-9]
- Natural killer T (NKT) cells modulate immune responses against pathogens and tumours, as well as immunological tolerance. We show here that CYLD, a tumour suppressor with deubiquitinase function, has a pivotal and cell-i...
- Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless
[作者：Miyazono, K; Zhi, YH; Takamura, Y; Nagata, K; Saigo, K; Kojima, T; Tanokura, M,期刊：EMBO journal, 页码：1613-1623 , 文章类型： Article，,卷期：2010年29-9]
- To achieve accurate gene regulation, some homeodomain proteins bind cooperatively to DNA to increase those site specificities. We report a ternary complex structure containing two homeodomain proteins, aristaless (Al) an...
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