- Postprandial Administration of Intranasal Insulin Intensifies Satiety and Reduces Intake of Palatable Snacks in Women
[作者:Hallschmid, M; Higgs, S; Thienel, M; Ott, V; Lehnert, H,期刊:Diabetes, 页码:782-789 , 文章类型: Article,,卷期:2012年61-4]
- The role of brain insulin signaling in the control of food intake in humans has not been thoroughly defined. We hypothesized that the hormone contributes to the postprandial regulation of appetite for palatable food, and...
- Salicylate Downregulates 11 beta-HSD1 Expression in Adipose Tissue in Obese Mice and in Humans, Mediating Insulin Sensitization
[作者:Nixon, M; Wake, DJ; Livingstone, DE; Stimson, RH; Esteves, CL; Seckl, JR; Chapman, KE; Andrew, R; Walker, BR,期刊:Diabetes, 页码:790-796 , 文章类型: Article,,卷期:2012年61-4]
- Recent trials show salicylates improve glycemic control in type 2 diabetes, but the mechanism is poorly understood. Expression of the glucocorticoid-generating enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-...
- Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3
[作者:Li, HT; Gao, ZG; Zhang, J; Ye, X; Xu, AM; Ye, JP; Jia, WP,期刊:Diabetes, 页码:797-806 , 文章类型: Article,,卷期:2012年61-4]
- Fibroblast growth factor 21 (FGF21) stimulates fatty acid oxidation and ketone body production in animals. In this study, we investigated the role of FGF21 in the metabolic activity of sodium butyrate, a dietary histone ...
- Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase
[作者:de Morentin, PBM; Whittle, AJ; Ferno, J; Nogueiras, R; Dieguez, C; Vidal-Puig, A; Lopez, M,期刊:Diabetes, 页码:807-817 , 文章类型: Article,,卷期:2012年61-4]
- Smokers around the world commonly report increased body weight after smoking cessation as a major factor that interferes with their attempts to quit. Numerous controlled studies in both humans and rodents have reported t...
- Islet beta-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model
[作者:Tersey, SA; Nishiki, Y; Templin, AT; Cabrera, SM; Stull, ND; Colvin, SC; Evans-Molina, C; Rickus, JL; Maier, B; Mirmira, RG,期刊:Diabetes, 页码:818-827 , 文章类型: Article,,卷期:2012年61-4]
- Type 1 diabetes is preceded by islet beta-cell dysfunction, but the mechanisms leading to beta-cell dysfunction have not been rigorously studied. Because immune cell infiltration occurs prior to overt diabetes, we hypoth...
- Impaired Cleavage of Preproinsulin Signal Peptide Linked to Autosomal-Dominant Diabetes
[作者:Liu, M; Lara-Lemus, R; Shan, SO; Wright, J; Haataja, L; Barbetti, F; Guo, H; Larkin, D; Arvan, P,期刊:Diabetes, 页码:828-837 , 文章类型: Article,,卷期:2012年61-4]
- Recently, missense mutations upstream of preproinsulin's signal peptide (SP) cleavage site were reported to cause mutant INS gene-induced diabetes of youth (MIDY). Our objective was to understand the molecular pathogenes...
- Hyperthermia With Mild Electrical Stimulation Protects Pancreatic beta-Cells From Cell Stresses and Apoptosis
[作者:Kondo, T; Sasaki, K; Matsuyama, R; Morino-Koga, S; Adachi, H; Suico, MA; Kawashima, J; Motoshima, H; Furukawa, N; Kai, H; Araki, E,期刊:Diabetes, 页码:838-847 , 文章类型: Article,,卷期:2012年61-4]
- Induction of heat shock protein (HSP) 72 improves metabolic profiles in diabetic model mice. However, its effect on pancreatic beta-cells is not known. The current study investigated whether HSP72 induction can reduce be...
- Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice
[作者:Nakayama, M; Castoe, T; Sosinowski, T; He, XL; Johnson, K; Haskins, K; Vignali, DAA; Gapin, L; Pollock, D; Eisenbarth, GS,期刊:Diabetes, 页码:857-865 , 文章类型: Article,,卷期:2012年61-4]
- There is accumulating evidence that autoimmunity to insulin B chain peptide, amino acids 9-23 (insulin B:9-23), is central to development of autoimmune diabetes of the NOD mouse model. We hypothesized that enhanced susce...
- Endothelial Progenitor Cell Cotransplantation Enhances Islet Engraftment by Rapid Revascularization
[作者:Kang, S; Park, HS; Jo, A; Hong, SH; Lee, HN; Lee, YY; Park, JS; Jung, HS; Chung, SS; Park, KS,期刊:Diabetes, 页码:866-876 , 文章类型: Article,,卷期:2012年61-4]
- Impaired revascularization of transplanted islets is a critical problem that leads to progressive islet loss. Since endothelial progenitor cells (EPCs) are known to aid neovascularization, we aimed to enhance islet engra...
- Regulation of Mitochondrial Biogenesis by Lipoprotein Lipase in Muscle of Insulin-Resistant Offspring of Parents With Type 2 Diabetes
[作者:Morino, K; Petersen, KF; Sono, S; Choi, CS; Samuel, VT; Lin, AP; Gallo, A; Zhao, HY; Kashiwagi, A; Goldberg, IJ; Wang, H; Eckel, RH; Maegawa, H; Shulman, GI,期刊:Diabetes, 页码:877-887 , 文章类型: Article,,卷期:2012年61-4]
- Recent studies reveal a strong relationship between reduced mitochondrial content and insulin resistance in human skeletal muscle, although the underlying factors responsible for this association remain unknown. To addre...
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