- Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila
[作者:Ouyang, YS; Petritsch, C; Wen, H; Jan, L; Jan, YN; Lu, BW,期刊:Development, 页码:2185-2196 , 文章类型: Article,,卷期:2011年138-11]
- Drosophila neuroblasts have served as a model to understand how the balance of stem cell self-renewal versus differentiation is achieved. Drosophila Numb protein regulates this process through its preferential segregatio...
- Coordinated expression of cell death genes regulates neuroblast apoptosis
[作者:Tan, Y; Yamada-Mabuchi, M; Arya, R; St Pierre, S; Tang, W; Tosa, M; Brachmann, C; White, K,期刊:Development, 页码:2197-2206 , 文章类型: Article,,卷期:2011年138-11]
- Properly regulated apoptosis in the developing central nervous system is crucial for normal morphogenesis and homeostasis. In Drosophila, a subset of neural stem cells, or neuroblasts, undergo apoptosis during embryogene...
- Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline
[作者:Fox, PM; Vought, VE; Hanazawa, M; Lee, MH; Maine, EM; Schedl, T,期刊:Development, 页码:2223-2234 , 文章类型: Article,,卷期:2011年138-11]
- The C. elegans germline provides an excellent model for analyzing the regulation of stem cell activity and the decision to differentiate and undergo meiotic development. The distal end of the adult hermaphrodite germline...
- p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium formation, placental vascularization and embryonic growth
[作者:Kashif, M; Hellwig, A; Kolleker, A; Shahzad, K; Wang, HJ; Lang, S; Wolter, J; Thati, M; Vinnikov, I; Bierhaus, A; Nawroth, PP; Isermann, B,期刊:Development, 页码:2235-2247 , 文章类型: Article,,卷期:2011年138-11]
- Absence of the leucine zipper transcription factor p45NF-E2 results in thrombocytopenia, impaired placental vascularization and intrauterine growth restriction (IUGR) in mice. The mechanism underlying the p45NF-E2-depend...
- Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis
[作者:Barron, F; Woods, C; Kuhn, K; Bishop, J; Howard, MJ; Clouthier, DE,期刊:Development, 页码:2249-2259 , 文章类型: Article,,卷期:2011年138-11]
- Lower jaw development is a complex process in which multiple signaling cascades establish a proximal-distal organization. These cascades are regulated both spatially and temporally and are constantly refined through both...
- Mps1 at kinetochores is essential for female mouse meiosis I
[作者:Hached, K; Xie, SZ; Buffin, E; Cladiere, D; Rachez, C; Sacras, M; Sorger, PK; Wassmann, K,期刊:Development, 页码:2261-2271 , 文章类型: Article,,卷期:2011年138-11]
- In female meiosis, chromosome missegregations lead to the generation of aneuploid oocytes and can cause the development of trisomies or infertility. Because mammalian female meiosis I is error prone, the full functionali...
- RSL genes are sufficient for rhizoid system development in early diverging land plants
[作者:Jang, G; Yi, KK; Pires, ND; Menand, B; Dolan, L,期刊:Development, 页码:2273-2281 , 文章类型: Article,,卷期:2011年138-11]
- Land plants are anchored to their substratum from which essential inorganic nutrients are taken up. These functions are carried out by a system of rhizoids in early diverging groups of land plants, such as mosses, liverw...
- DPP-mediated TGF beta signaling regulates juvenile hormone biosynthesis by activating the expression of juvenile hormone acid methyltransferase
[作者:Huang, JH; Tian, L; Peng, C; Abdou, M; Wen, D; Wang, Y; Li, S; Wang, J,期刊:Development, 页码:2283-2291 , 文章类型: Article,,卷期:2011年138-11]
- Juvenile hormone (JH) biosynthesis in the corpus allatum (CA) is regulated by neuropeptides and neurotransmitters produced in the brain. However, little is known about how these neural signals induce changes in JH biosyn...
- BMP signaling orchestrates photoreceptor specification in the zebrafish pineal gland in collaboration with Notch
[作者:Quillien, A; Blanco-Sanchez, B; Halluin, C; Moore, JC; Lawson, ND; Blader, P; Cau, E,期刊:Development, 页码:2293-2302 , 文章类型: Article,,卷期:2011年138-11]
- A variety of signaling pathways have been shown to regulate specification of neuronal subtype identity. However, the mechanisms by which future neurons simultaneously process information from multiple pathways to establi...
- Engrailed homeoprotein acts as a signaling molecule in the developing fly
[作者:Layalle, S; Volovitch, M; Mugat, B; Bonneaud, N; Parmentier, ML; Prochiantz, A; Joliot, A; Maschat, F,期刊:Development, 页码:2315-2323 , 文章类型: Article,,卷期:2011年138-11]
- Homeodomain transcription factors classically exert their morphogenetic activities through the cell-autonomous regulation of developmental programs. In vertebrates, several homeoproteins have also been shown to have dire...
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