- Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactions
[作者:Sala-Valdes, M; Gordon-Alonso, M; Tejera, E; Ibanez, A; Cabrero, JR; Ursa, A; Mittelbrunn, M; Lozano, F; Sanchez-Madrid, F; Yanez-Mo, M,期刊:Journal of cell science, 页码:1235-1246 , 文章类型: Article,,卷期:2012年125-5]
- In this study, we describe that the PDZ protein syntenin-1 is a crucial element for the generation of signaling asymmetry during the cellular response to polarized extracellular cues. We analyze the role of syntenin-1 in...
- Lysosome fusion to the cell membrane is mediated by the dysferlin C2A domain in coronary arterial endothelial cells
[作者:Han, WQ; Xia, M; Xu, M; Boini, KM; Ritter, JK; Li, NJ; Li, PL,期刊:Journal of cell science, 页码:1225-1234 , 文章类型: Article,,卷期:2012年125-5]
- Dysferlin has recently been reported to participate in cell membrane repair in muscle and other cells through lysosome fusion. Given that lysosome fusion is a crucial mechanism that leads to membrane raft clustering, the...
- Syntenin, a syndecan adaptor and an Arf6 phosphatidylinositol 4,5-bisphosphate effector, is essential for epiboly and gastrulation cell movements in zebrafish
[作者:Lambaerts, K; Van Dyck, S; Mortier, E; Ivarsson, Y; Degeest, G; Luyten, A; Vermeiren, E; Peers, B; David, G; Zimmermann, P,期刊:Journal of cell science, 页码:1129-1140 , 文章类型: Article,,卷期:2012年125-5]
- Epiboly, the spreading and the thinning of the blastoderm to cover the yolk cell and close the blastopore in fish embryos, is central to the process of gastrulation. Despite its fundamental importance, little is known ab...
- TGF-beta-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion
[作者:Lamouille, S; Connolly, E; Smyth, JW; Akhurst, RJ; Derynck, R,期刊:Journal of cell science, 页码:1259-1273 , 文章类型: Article,,卷期:2012年125-5]
- In cancer progression, carcinoma cells gain invasive behavior through a loss of epithelial characteristics and acquisition of mesenchymal properties, a process that can lead to epithelial-mesenchymal transition (EMT). TG...
- Cell-cycle-regulated expression of STIL controls centriole number in human cells
[作者:Arquint, C; Sonnen, KF; Stierhof, YD; Nigg, EA,期刊:Journal of cell science, 页码:1342-1352 , 文章类型: Article,,卷期:2012年125-5]
- Control of centriole number is crucial for genome stability and ciliogenesis. Here, we characterize the role of human STIL, a protein that displays distant sequence similarity to the centriole duplication factors Ana2 in...
- Mitogen-activated protein kinase (MAPK/ERK) regulates adenomatous polyposis coli during growth-factor-induced cell extension
[作者:Caro-Gonzalez, HY; Nejsum, LN; Siemers, KA; Shaler, TA; Nelson, WJ; Barth, AIM,期刊:Journal of cell science, 页码:1247-1258 , 文章类型: Article,,卷期:2012年125-5]
- Regulation of the microtubule- and actin-binding protein adenomatous polyposis coli (APC) is crucial for the formation of cell extensions in many cell types. This process requires inhibition of glycogen synthase kinase-3...
- CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity
[作者:Monterisi, S; Favia, M; Guerra, L; Cardone, RA; Marzulli, D; Reshkin, SJ; Casavola, V; Zaccolo, M,期刊:Journal of cell science, 页码:1106-1117 , 文章类型: Article,,卷期:2012年125-5]
- The cystic fibrosis transmembrane conductance regulator (CFTR) mutation Delta F508CFTR still causes regulatory defects when rescued to the apical membrane, suggesting that the intracellular milieu might affect its abilit...
- NF-kappa B regulates protein quality control after heat stress through modulation of the BAG3-HspB8 complex
[作者:Nivon, M; Abou-Samra, M; Richet, E; Guyot, B; Arrigo, AP; Kretz-Remy, C,期刊:Journal of cell science, 页码:1141-1151 , 文章类型: Article,,卷期:2012年125-5]
- We previously found that the NF-kappa B transcription factor is activated during the recovery period after heat shock; moreover, we demonstrated that NF-kappa B is essential for cell survival after heat shock by activati...
- The molecular chaperone Hsp47 is essential for cartilage and endochondral bone formation
[作者:Masago, Y; Hosoya, A; Kawasaki, K; Kawano, S; Nasu, A; Toguchida, J; Fujita, K; Nakamura, H; Kondoh, G; Nagata, K,期刊:Journal of cell science, 页码:1118-1128 , 文章类型: Article,,卷期:2012年125-5]
- Heat shock protein 47 kDa (Hsp47) is considered as a molecular chaperone essential for the correct folding of type I and type IV procollagen in the ER. However, the function of Hsp47 for other types of procollagen and it...
- FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3
[作者:Hagenbuchner, J; Kuznetsov, A; Hermann, M; Hausott, B; Obexer, P; Ausserlechner, MJ,期刊:Journal of cell science, 页码:1191-1203 , 文章类型: Article,,卷期:2012年125-5]
- FOXO transcription factors induce apoptosis and regulate cellular production of reactive oxygen species (ROS). To identify the sequence of molecular events underlying FOXO3 (FKHRL1)-induced apoptosis, we studied the regu...
- Presenilin-2 regulates the degradation of RBP-Jk protein through p38 mitogen-activated protein kinase
[作者:Kim, SM; Kim, MY; Ann, EJ; Mo, JS; Yoon, JH; Park, HS,期刊:Journal of cell science, 页码:1296-1308 , 文章类型: Article,,卷期:2012年125-5]
- Transcriptional regulation performs a central role in Notch1 signaling by recombining binding protein Suppressor of Hairless (RBP-Jk) - a signaling pathway that is widely involved in determination of cell fate. Our earli...
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