- Epigenetic regulation of the alternatively activated macrophage phenotype
[作者：Ishii, M; Wen, HT; Corsa, CAS; Liu, TJ; Coelho, AL; Allen, RM; Carson, WF; Cavassani, KA; Li, XZ; Lukacs, NW; Hogaboam, CM; Dou, YL; Kunkel, SL,期刊：Blood, 页码：3244-3254 , 文章类型： Article，,卷期：2009年114-15]
- Alternatively activated (M2) macrophages play critical roles in diverse chronic diseases, including parasite infections, cancer, and allergic responses. However, little is known about the acquisition and maintenance of t...
- miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia
[作者：Pallasch, CP; Patz, M; Park, YJ; Hagist, S; Eggle, D; Claus, R; Debey-Pascher, S; Schulz, A; Frenzel, LP; Claasen, J; Kutsch, N; Krause, G; Mayr, C; Rosenwald, A; Plass, C; Schultze, JL; Hallek, M; Wendtner, CM,期刊：Blood, 页码：3255-3264 , 文章类型： Article，,卷期：2009年114-15]
- MicroRNAs (miRNA) play a key role in cellular regulation and, if deregulated, in the development of neoplastic disorders including chronic lymphocytic leukemia (CLL). RNAs from primary cells of 50 treatment-naive CLL pat...
- Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia
[作者：Yamanaka, Y; Tagawa, H; Takahashi, N; Watanabe, A; Guo, YM; Iwamoto, K; Yamashita, J; Saitoh, H; Kameoka, Y; Shimizu, N; Ichinohasama, R; Sawada, K,期刊：Blood, 页码：3265-3275 , 文章类型： Article，,卷期：2009年114-15]
- The gene(s) responsible for natural killer (NK)-cell lymphoma/leukemia have not been identified. In the present study, we found that in NK-cell lymphoma lines (n = 10) and specimens of primary lymphoma (n = 10), levels o...
- Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance
[作者：Blotta, S; Tassone, P; Prabhala, RH; Tagliaferri, P; Cervi, D; Amin, S; Jakubikova, J; Tai, YT; Podar, K; Mitsiades, CS; Zullo, A; Franco, B; Anderson, KC; Munshi, NC,期刊：Blood, 页码：3276-3284 , 文章类型： Article，,卷期：2009年114-15]
- The transformation from monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) is thought to be associated with changes in immune processes. We have therefore used serologic analysis of recomb...
- TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs)
[作者：Kosmider, O; Gelsi-Boyer, V; Cheok, M; Grabar, S; Della-Valle, V; Picard, F; Viguie, F; Quesnel, B; Beyne-Rauzy, O; Solary, E; Vey, N; Hunault-Berger, M; Fenaux, P; Mansat-De Mas, V; Delabesse, E; Guardiola, P; Lacombe, C; Vainchenker, W; Preudhomme, C; Dreyfus, F; Bernard, OA; Birnbaum, D; Fontenay, M,期刊：Blood, 页码：3285-3291 , 文章类型： Article，,卷期：2009年114-15]
- Oncogenic pathways underlying in the development of myelodysplastic syndromes (MDS) remain poorly characterized, but mutations of the ten-eleven translocation 2 (TET2) gene are frequently observed. In the present work, w...
- The derivation of diagnostic markers of chronic myeloid leukemia progression from microarray data
[作者：Oehler, VG; Yeung, KY; Choi, YE; Bumgarner, RE; Raftery, AE; Radich, JP,期刊：Blood, 页码：3292-3298 , 文章类型： Article，,卷期：2009年114-15]
- Currently, limited molecular markers exist that can determine where in the spectrum of chronic myeloid leukemia (CML) progression an individual patient falls at diagnosis. Gene expression profiles can predict disease and...
- The preferentially expressed antigen in melanoma (PRAME) inhibits myeloid differentiation in normal hematopoietic and leukemic progenitor cells
[作者：Oehler, VG; Guthrie, KA; Cummings, CL; Sabo, K; Wood, BL; Gooley, T; Yang, TM; Epping, MT; Shou, YP; Pogosova-Agadjanyan, E; Ladne, P; Stirewalt, DL; Abkowitz, JL; Radich, JP,期刊：Blood, 页码：3299-3308 , 文章类型： Article，,卷期：2009年114-15]
- The preferentially expressed antigen in melanoma (PRAME) is expressed in several hematologic malignancies, but either is not expressed or is expressed at only low levels in normal hematopoietic cells, making it a target ...
- A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40(phox) and selective defects in neutrophil NADPH oxidase activity
[作者：Matute, JD; Arias, AA; Wright, NAM; Wrobel, I; Waterhouse, CCM; Li, XJ; Marchal, CC; Stull, ND; Lewis, DB; Steele, M; Kellner, JD; Yu, WM; Meroueh, SO; Nauseef, WM; Dinauer, MC,期刊：Blood, 页码：3309-3315 , 文章类型： Article，,卷期：2009年114-15]
- Chronic granulomatous disease (CGD), an immunodeficiency with recurrent pyogenic infections and granulomatous inflammation, results from loss of phagocyte superoxide production by recessive mutations in any 1 of 4 genes ...
- The Asn505 mutation of the c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity
[作者：Ding, JM; Komatsu, H; Iida, S; Yano, H; Kusumoto, S; Inagaki, A; Mori, F; Ri, M; Ito, A; Wakita, A; Ishida, T; Nitta, M; Ueda, R,期刊：Blood, 页码：3325-3328 , 文章类型： Article，,卷期：2009年114-15]
- We previously reported that a dominant-positive activating mutation (Asn505) in the transmembrane domain (TMD) of c-MPL, which encodes the thrombopoietin receptor, caused familial essential thrombocythemia. Here, we show...
- vonWillebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke
[作者：Zhao, BQ; Chauhan, AK; Canault, M; Patten, IS; Yang, JJ; Dockal, M; Scheiflinger, F; Wagner, DD,期刊：Blood, 页码：3329-3334 , 文章类型： Article，,卷期：2009年114-15]
- Stroke is a leading cause of death and disability. The only therapy available is recombinant tissue plasminogen activator, but side effects limit its use. Platelets play a crucial role during stroke, and the inflammatory...
- HIV-1 Tat and heparan sulfate proteoglycan interaction: a novel mechanism of lymphocyte adhesion and migration across the endothelium
[作者：Urbinati, C; Nicoli, S; Giacca, M; David, G; Fiorentini, S; Caruso, A; Alfano, M; Cassetta, L; Presta, M; Rusnati, M,期刊：Blood, 页码：3335-3342 , 文章类型： Article，,卷期：2009年114-15]
- The HIV-1 transactivating factor Tat accumulates on the surface of endothelium by interacting with heparan sulfate proteoglycans (HSPGs). Tat also interacts with B-lymphoid Namalwa cells but only when these overexpress H...
- Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein
[作者：Suzuki, Y; Nagai, N; Yamakawa, K; Kawakami, J; Lijnen, HR; Umemura, K,期刊：Blood, 页码：3352-3358 , 文章类型： Article，,卷期：2009年114-15]
- Tissue-type plasminogen activator (t-PA) is approved for treatment of ischemic stroke patients, but it increases the risk of intracranial bleeding (ICB). Previously, we have shown in a mouse stroke model that stromelysin...
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