- Phosphoinositide phosphatase SHIP-1 regulates apoptosis induced by edelfosine, Fas ligation and DNA damage in mouse lymphoma cells
[作者:Alderliesten, MC; Klarenbeek, JB; van der Luit, AH; van Lummel, M; Jones, DR; Zerp, S; Divecha, N; Verheij, M; van Blitterswijk, WJ,期刊:Biochemical Journal, 页码:127-135 , 文章类型: Article,,卷期:2011年440-1]
- S49 mouse lymphoma cells undergo apoptosis in response to the ALP (alkyl-lysophospholipid) edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine), FasL (Fits ligand) and DNA damage. S49 cells made resistant t...
- Rim2, a pyrimidine nucleotide exchanger, is needed for iron utilization in mitochondria
[作者:Yoon, H; Zhang, Y; Pain, J; Lyver, ER; Lesuisse, E; Pain, D; Dancis, A,期刊:Biochemical Journal, 页码:137-146 , 文章类型: Article,,卷期:2011年440-1]
- Mitochondria transport and utilize iron for the synthesis of haem and Fe-S clusters. Although many proteins are known to be involved in these processes, additional proteins are likely to participate. To test this hypothe...
- Monoclonal antibodies reveal the alteration of the rhodocetin structure upon alpha 2 beta 1 integrin binding
[作者:Bracht, T; de Rezende, FF; Stetefeld, J; Sorokin, LM; Eble, JA,期刊:Biochemical Journal, 页码:1-11 , 文章类型: Article,,卷期:2011年440-1]
- The alpha 2 beta 1 antagonist rhodocetin from Calloselasma rhodostoma is a heterotetrameric CLRP (C-type lectin-related protein) consisting of four distinct chains, alpha, beta, gamma and delta. Via their characteristic ...
- Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p
[作者:Martin-Montalvo, A; Gonzalez-Mariscal, I; Padilla, S; Ballesteros, M; Brautigan, DL; Navas, P; Santos-Ocana, C,期刊:Biochemical Journal, 页码:107-114 , 文章类型: Article,,卷期:2011年440-1]
- CoQ(6) (coenzyme Q(6)) biosynthesis in yeast is a well-regulated process that requires the final conversion of the late intermediate DMQ(6) (demethoxy-CoQ(6)) into CoQ(6) in order to support respiratory metabolism in yea...
- MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines
[作者:Liu, XQ; Wang, C; Chen, ZJ; Jin, Y; Wang, Y; Kolokythas, A; Dai, Y; Zhou, XF,期刊:Biochemical Journal, 页码:23-31 , 文章类型: Article,,卷期:2011年440-1]
- Down-regulation of miR-138 (microRNA-138) has been frequently observed in various cancers, including HNSCC (head and neck squamous cell carcinoma). Our previous studies suggest that down-regulation of miR-138 is associat...
- Retention in the Golgi apparatus and expression on the cell surface of Cfr/Esl-1/Glg-1/MG-160 are regulated by two distinct mechanisms
[作者:Miyaoka, Y; Kato, H; Ebato, K; Saito, S; Miyata, N; Imamura, T; Miyajima, A,期刊:Biochemical Journal, 页码:33-41 , 文章类型: Article,,卷期:2011年440-1]
- Cfr (cysteine-rich fibroblast growth factor receptor) is an Fgf (fibroblast growth factor)-binding protein without a tyrosine kinase. We have shown previously that Cfr is involved in Fgf18 signalling via Fgf receptor 3c....
- The light intensity under which cells are grown controls the type of peripheral light-harvesting complexes that are assembled in a purple photosynthetic bacterium
[作者:Brotosudarmo, THP; Collins, AM; Gall, A; Roszak, AW; Gardiner, AT; Blankenship, RE; Cogdell, RJ,期刊:Biochemical Journal, 页码:51-61 , 文章类型: Article,,卷期:2011年440-1]
- The differing composition of LH2 (peripheral light-harvesting) complexes present in Rhodopseudomonas palustris 2.1.6 have been investigated when cells are grown under progressively decreasing light intensity. Detailed an...
- Induction of an incomplete autophagic response by cancer-preventive geranylgeranoic acid (GGA) in a human hepatoma-derived cell line
[作者:Okamoto, K; Sakimoto, Y; Imai, K; Senoo, H; Shidoji, Y,期刊:Biochemical Journal, 页码:63-71 , 文章类型: Article,,卷期:2011年440-1]
- GGA (geranylgeranoic acid) is a natural polyprenoic acid, derivatives of which has been shown to prevent second primary hepatoma. GGA induces mitochondria-mediated PCD (programmed cell death), which may be relevant to ca...
- The P(2)' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity
[作者:Salameh, MA; Soares, AS; Hockla, A; Radisky, DC; Radisky, ES,期刊:Biochemical Journal, 页码:95-105 , 文章类型: Article,,卷期:2011年440-1]
- PRSS3/mesotrypsin is an atypical isoform of trypsin, the up-regulation of which has been implicated in promoting tumour progression. Mesotrypsin inhibitors could potentially provide valuable research tools and novel ther...
|