- Novel insights into the regulation of antioxidant-response-element-mediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2
[作者：Jyrkkanen, HK; Kuosmanen, S; Heinaniemi, M; Laitinen, H; Kansanen, E; Mella-Aho, E; Leinonen, H; Yla-Herttuala, S; Levonen, AL,期刊：Biochemical Journal, 页码：167-174 , 文章类型： Article，,卷期：2011年440-2]
- A central mechanism in cellular defence against oxidative or electrophilic stress is mediated by transcriptional induction of genes via the ARE (antioxidant-response element), a cis-acting sequence present in the regulat...
- Treatment of doxorubicin-resistant MCF7/Dx cells with nitric oxide causes histone glutathionylation and reversal of drug resistance
[作者：De Luca, A; Moroni, N; Serafino, A; Primavera, A; Pastore, A; Pedersen, JZ; Petruzzelli, R; Farrace, MG; Pierimarchi, P; Moroni, G; Federici, G; Vallebona, PS; Lo Bello, M,期刊：Biochemical Journal, 页码：175-183 , 文章类型： Article，,卷期：2011年440-2]
- Acquired drug resistance was found to be suppressed in the doxorubicin-resistant breast cancer cell line MCF7/Dx after pre-treatment with GSNO (nitrosoglutathione). The effect was accompanied by enhanced protein glutathi...
- Intracellular curvature-generating proteins in cell-to-cell fusion
[作者：Richard, JP; Leikina, E; Langen, R; Henne, WM; Popova, M; Balla, T; McMahon, HT; Kozlov, MM; Chernomordik, LV,期刊：Biochemical Journal, 页码：185-193 , 文章类型： Article，,卷期：2011年440-2]
- Cell-to-cell fusion plays an important role in normal physiology and in different pathological conditions. Early fusion stages mediated by specialized proteins and yielding fusion pores are followed by a pore expansion s...
- The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance
[作者：Cabrito, TR; Teixeira, MC; Singh, A; Prasad, R; Sa-Correia, I,期刊：Biochemical Journal, 页码：195-202 , 文章类型： Article，,卷期：2011年440-2]
- The action of multidrug efflux pumps in MDR (multidrug resistance) acquisition has been proposed to partially depend on the transport of physiological substrates which may indirectly affect drug partition and transport a...
- Mutational analysis of allosteric activation and inhibition of glucokinase
[作者：Zelent, B; Odili, S; Buettger, C; Zelent, DK; Chen, P; Fenner, D; Bass, J; Stanley, C; Laberge, M; Vanderkooi, JM; Sarabu, R; Grimsby, J; Matschinsky, FM,期刊：Biochemical Journal, 页码：203-215 , 文章类型： Article，,卷期：2011年440-2]
- GK (glucokinase) is activated by glucose binding to its substrate site, is inhibited by GKRP (GK regulatory protein) and stimulated by GKAs (GK activator drugs). To explore further the mechanisms of these processes we st...
- Peripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetase
[作者：Liu, RJ; Tan, M; Du, DH; Xu, BS; Eriani, G; Wang, ED,期刊：Biochemical Journal, 页码：217-227 , 文章类型： Article，,卷期：2011年440-2]
- A large insertion domain called CP1 (connective peptide I) present in class Ia aminoacyl-tRNA synthetases is responsible for post-transfer editing. LeuRS (leucyl-tRNA synthetase) from Aquifex aeolicus and Giardia lamblia...
- Overexpression of a cytosolic pyrophosphatase (TgPPase) reveals a regulatory role of PP(i) in glycolysis for Toxoplasma gondii
[作者：Pace, DA; Fang, JM; Cintron, R; Docampo, MD; Moreno, SNJ,期刊：Biochemical Journal, 页码：229-240 , 文章类型： Article，,卷期：2011年440-2]
- PP(i) is a critical element of cellular metabolism as both an energy donor and as an allosteric regulator of several metabolic pathways. The apicomplexan parasite Toxoplasma gondii uses PP, in place of ATP as an energy d...
- The heterotrimeric G protein subunits G alpha(q) and G beta(1) have lysophospholipase D activity
[作者：Aoyama, C; Sugimoto, H; Ando, H; Yamashita, S; Horibata, Y; Sugimoto, S; Satou, M,期刊：Biochemical Journal, 页码：241-250 , 文章类型： Article，,卷期：2011年440-2]
- In a previous study we purified a novel lysoPLD (lysophospholipase D) which converts LPC (lysophosphatidylcholine) into a bioactive phospholipid, LPA (lysophosphatidic acid), from the rat brain. In the present study, we ...
- A novel protein from the serum of Python sebae, structurally homologous with type-gamma phospholipase A(2) inhibitor, displays antitumour activity
[作者：Donnini, S; Finetti, F; Francese, S; Boscaro, F; Dani, FR; Maset, F; Frasson, R; Palmieri, M; Pazzagli, M; De Filippis, V; Garaci, E; Ziche, M,期刊：Biochemical Journal, 页码：251-262 , 文章类型： Article，,卷期：2011年440-2]
- Cytotoxic and antitumour factors have been documented in the venom of snakes, although little information is available on the identification of cytotoxic products in snake serum. In the present study, we purified and cha...
- Heparanase enhances nerve-growth-factor-induced PC12 cell neuritogenesis via the p38 MAPK pathway
[作者：Cui, HX; Shao, CH; Liu, Q; Yu, WJ; Fang, JP; Yu, WS; Ali, A; Ding, K,期刊：Biochemical Journal, 页码：273-282 , 文章类型： Article，,卷期：2011年440-2]
- Heparanase is involved in the cleavage of the HS (heparan sulfate) chain of HSPGs (HS proteoglycans) and hence participates in remodelling of the ECM (extracellular matrix) and BM (basement membrane). In the present stud...
- The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus
[作者：Veno, ST; Kulikowicz, T; Pestana, C; Stepien, PP; Stevnsner, T; Bohr, VA,期刊：Biochemical Journal, 页码：293-300 , 文章类型： Article，,卷期：2011年440-2]
- The hSuv3 (human Suv3) helicase has been shown to be a major player in mitochondrial RNA surveillance and decay, but its physiological role might go beyond this functional niche. hSuv3 has been found to interact with BLM...
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