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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   Salmonella enterica serotype Typhimurium usurps the scaffold protein IQGAP1 to manipulate Rac1 and MAPK signalling [作者：Kim, H; White, CD; Li, ZG; Sacks, DB,期刊：Biochemical Journal, 页码：309-318 , 文章类型： Article，,卷期：2011年440-3] Salmonella enterica serotype Typhimurium invades eukaryotic cells by re-arranging the host-cell cytoskeleton. However, the precise mechanisms by which Salmonella induces cytoskeletal changes remain undefined. IQGAP1 (IQ ... Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer [作者：Itoh, Y; Palmisano, R; Anilkumar, N; Nagase, H; Miyawaki, A; Seiki, M,期刊：Biochemical Journal, 页码：319-326 , 文章类型： Article，,卷期：2011年440-3] Homodimerization of the membrane-bound collagenase MT1-MMP [membrane-type 1 MMP (matrix metalloproteinase)] is crucial for its collagenolytic activity. However, it is not clear whether this dimerization is regulated duri... Protein kinase D controls voluntary-running-induced skeletal muscle remodelling [作者：Ellwanger, K; Kienzle, C; Lutz, S; Jin, ZG; Wiekowski, MT; Pfizenmaier, K; Hausser, A,期刊：Biochemical Journal, 页码：327-334 , 文章类型： Article，,卷期：2011年440-3] Skeletal muscle responds to exercise by activation of signalling pathways that co-ordinate gene expression to sustain muscle performance. MEF2 (myocyte enhancer factor 2)-dependent transcriptional activation of MHC (myos... Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily [作者：Ruiz, FX; Porte, S; Gallego, O; Moro, A; Ardevol, A; Del Rio-Espinola, A; Rovira, C; Farres, J; Pares, X,期刊：Biochemical Journal, 页码：335-344 , 文章类型： Article，,卷期：2011年440-3] Human AKR (aldo-keto reductase) 1C proteins (AKR1C1-AKR1C4) exhibit relevant activity with steroids, regulating hormone signalling at the pre-receptor level. In the present study, investigate the activity of the four hum... Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate [作者：Kharel, Y; Mathews, TP; Gellett, AM; Tomsig, JL; Kennedy, PC; Moyer, ML; Macdonald, TL; Lynch, KR,期刊：Biochemical Journal, 页码：345-353 , 文章类型： Article，,卷期：2011年440-3] S1P (sphingosine 1-phosphate) is a signalling molecule involved in a host of cellular and physiological functions, most notably cell survival and migration. SIP, which signals via a set of five G-protein-coupled receptor... Ionotropic glutamate receptor (iGluR)-like channels mediate MAMP-induced calcium influx in Arabidopsis thaliana [作者：Kwaaitaal, M; Huisman, R; Maintz, J; Reinstadler, A; Panstruga, R,期刊：Biochemical Journal, 页码：355-365 , 文章类型： Article，,卷期：2011年440-3] Binding of specific microbial epitopes [MAMPs (microbe-associated molecular patterns)] to PRRs (pattern recognition receptors) and subsequent receptor kinase activation are key steps in plant innate immunity. One of the ... Structural stabilization of protein 4.1R FERM domain upon binding to apo-calmodulin: novel insights into the biological significance of the calcium-independent binding of calmodulin to protein 4.1R [作者：Nunomura, W; Sasakura, D; Shiba, K; Nakamura, S; Kidokoro, S; Takakuwa, Y,期刊：Biochemical Journal, 页码：367-374 , 文章类型： Article，,卷期：2011年440-3] In erythrocytes, 4.1R(80) (80 kDa isoform of protein 4.1R) binds to the cytoplasmic tail of the transmembrane proteins band 3 and GPC (glycophorin C), and to the membrane-associated protein p55 through the N- (N-terminal... Alternative pathways of dehydroascorbic acid degradation in vitro and in plant cell cultures: novel insights into vitamin C catabolism [作者：Parsons, HT; Yasmin, T; Fry, SC,期刊：Biochemical Journal, 页码：375-383 , 文章类型： Article，,卷期：2011年440-3] L-Ascorbate catabolism involves reversible oxidation to DHA (dehydroascorbic acid), then irreversible oxidation or hydrolysis. The precursor-product relationships and the identity of several major DHA breakdown products ... Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis [作者：Handy, JA; Fu, PP; Kumar, P; Mells, JE; Sharma, S; Saxena, NK; Anania, FA,期刊：Biochemical Journal, 页码：385-395 , 文章类型： Article，,卷期：2011年440-3] Adiponectin is protective against hepatic fibrosis, whereas leptin promotes fibrosis. In HSCs (hepatic stellate cells), leptin signals via a JAK2 (Janus kinase 2)/STAT3 (signal transducer and activator of transcription 3... Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms [作者：Knudsen, L; De Meyts, P; Kiselyov, VV,期刊：Biochemical Journal, 页码：397-403 , 文章类型： Article，,卷期：2011年440-3] More than 20 years after the description of the two IR (insulin receptor) isoforms, designated IR-A (lacking exon 11) and IR-B (with exon 11), nearly every functional aspect of the alternative splicing both in vitro and ... Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684 [作者：Schonherr, C; Ruuth, K; Yamazaki, Y; Eriksson, T; Christensen, J; Palmer, RH; Hallberg, B,期刊：Biochemical Journal, 页码：405-413 , 文章类型： Article，,卷期：2011年440-3] Mutations in the kinase domain of ALK (anaplastic lymphoma kinase) have recently been shown to be important for the progression of the childhood tumour neuroblastoma. In the present study we investigate six of the putati... Receptor-isoform-selective insulin analogues give tissue-preferential effects [作者：Vienberg, SG; Bouman, SD; Sorensen, H; Stidsen, CE; Kjeldsen, T; Glendorf, T; Sorensen, AR; Olsen, GS; Andersen, B; Nishimura, E,期刊：Biochemical Journal, 页码：301-308 , 文章类型： Article，,卷期：2011年440-3] The relative expression patterns of the two IR (insulin receptor) isoforms, +/- exon 11 (IR-B/IR-A respectively), are tissue-dependent. Therefore we have developed insulin analogues with different binding affinities for ...