- Effects on antigen-presenting cells of short-term interaction with the human host defence peptide beta-defensin 2
[作者:Morgera, F; Pacor, S; Creatti, L; Antcheva, N; Vaccari, L; Tossi, A,期刊:Biochemical Journal, 页码:537-546 , 文章类型: Article,,卷期:2011年436-Part 3]
- beta-Defensins are antimicrobial peptides that exert their host-defence functions at the interface between the host and microbial biota. They display a direct, salt- and medium-sensitive cidal activity, in vitro, against...
- Conservation of targeting but divergence in function and quality control of peroxisomal ABC transporters: an analysis using cross-kingdom expression
[作者:Zhang, XB; Lousa, CD; Schutte-Lensink, N; Ofman, R; Wanders, RJ; Baldwin, SA; Baker, A; Kemp, S; Theodoulou, FL,期刊:Biochemical Journal, 页码:547-557 , 文章类型: Article,,卷期:2011年436-Part 3]
- ABC (ATP-binding cassette) subfamily D transporters are found in all eukaryotic kingdoms and are known to play essential roles in mammals and plants; however, their number, organization and physiological contexts differ....
- Super toxins from a super bug: structure and function of Clostridium difficile toxins
[作者:Davies, AH; Roberts, AK; Shone, CC; Acharya, KR,期刊:Biochemical Journal, 页码:517-526 , 文章类型: Review,,卷期:2011年436-Part 3]
- Clostridium difficile, a highly infectious bacterium, is the leading cause of antibiotic-associated pseudomembranous colitis. In 2009, the number of death certificates mentioning C. difficile infection in the U.K. was es...
- Structural and enzymatic characterization of a glycoside hydrolase family 31 alpha-xylosidase from Cellvibrio japonicus involved in xyloglucan saccharification
[作者:Larsbrink, J; Izumi, A; Ibatullin, FM; Nakhai, A; Gilbert, HJ; Davies, GJ; Brumer, H,期刊:Biochemical Journal, 页码:567-580 , 文章类型: Article,,卷期:2011年436-Part 3]
- The desire for improved methods of biomass conversion into fuels and feedstocks has re-awakened interest in the enzymology of plant cell wall degradation. The complex polysaccharide xyloglucan is abundant in plant matter...
- Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity
[作者:Nikolaeva, O; Moiseyev, G; Rodgers, KK; Ma, JX,期刊:Biochemical Journal, 页码:591-597 , 文章类型: Article,,卷期:2011年436-Part 3]
- The visual cycle is a multi-step pathway to recycle 11-cis retinal, the chromophore for both rod and cone visual pigments. The isomerohydrolase RPE65, a membrane-associated enzyme, converts atRE (all-trans-retinyl ester)...
- Inducing toxicity by introducing a leucine-zipper-like motif in frog antimicrobial peptide, magainin 2
[作者:Pandey, BK; Srivastava, S; Singh, M; Ghosh, JK,期刊:Biochemical Journal, 页码:609-620 , 文章类型: Article,,卷期:2011年436-Part 3]
- Cytotoxicity, a major obstacle in therapeutic application of antimicrobial peptides, is controlled by leucine-zipper-like sequences in melittin and other naturally occurring antimicrobial peptides. Magainin 2 shows signi...
- Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11 beta-hydroxysteroid dehydrogenase 1
[作者:Odermatt, A; Da Cunha, T; Penno, CA; Chandsawangbhuwana, C; Reichert, C; Wolf, A; Dong, M; Baker, ME,期刊:Biochemical Journal, 页码:621-629 , 文章类型: Article,,卷期:2011年436-Part 3]
- The oxidized bile acid 7-oxoLCA (7-oxolithocholic acid), formed primarily by gut micro-organisms, is reduced in human liver to CDCA (chenodeoxycholic acid) and, to a lesser extent, UDCA (ursodeoxycholic acid). The enzyme...
- GULP1 is a novel APP-interacting protein that alters APP processing
[作者:Hao, CY; Perkinton, MS; Chan, WWL; Chan, HYE; Miller, CCJ; Lau, KF,期刊:Biochemical Journal, 页码:631-639 , 文章类型: Article,,卷期:2011年436-Part 3]
- Altered production of A beta (amyloid-beta peptide), derived from the proteolytic cleavage of APP (amyloid precursor protein), is believed to be central to the pathogenesis of AD (Alzheimer's disease). Accumulating evide...
- Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase: a unique bifunctional enzyme from Plasmodium falciparum
[作者:Jortzik, E; Mailu, BM; Preuss, J; Fischer, M; Bode, L; Rahlfs, S; Becker, K,期刊:Biochemical Journal, 页码:641-650 , 文章类型: Article,,卷期:2011年436-Part 3]
- The survival of malaria parasites in human RBCs (red blood cells) depends on the pentose phosphate pathway, both in Plasmodium falciparum and its human host. G6PD (glucose-6-phosphate dehydrogenase) deficiency, the most ...
- 5-HT2A receptor signalling through phospholipase D1 associated with its C-terminal tail
[作者:Barclay, Z; Dickson, L; Robertson, DN; Johnson, MS; Holland, PJ; Rosie, R; Sun, LT; Fleetwood-Walker, S; Lutz, EM; Mitchell, R,期刊:Biochemical Journal, 页码:651-660 , 文章类型: Article,,卷期:2011年436-Part 3]
- The 5-HT2AR (5-hydroxytryptamine-2A receptor) is a GPCR (G-protein-coupled receptor) that is implicated in the actions of hallucinogens and represents a major target of atypical antipsychotic agents. In addition to its c...
- Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers
[作者:Zaremba, T; Thomas, HD; Cole, M; Coulthard, SA; Plummer, ER; Curtin, NJ,期刊:Biochemical Journal, 页码:671-679 , 文章类型: Article,,卷期:2011年436-Part 3]
- There is a wide inter-individual variation in PARP-1 {PAR [poly(ADP-ribose)] polymerase 1} activity, which may have implications for health. We investigated if the variation: (i) is due to polymorphisms in the PARP-1 gen...
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