- Cyclodextrin, a novel therapeutic tool for suppressing amyloidogenic transthyretin misfolding in transthyretin-related amyloidosis
[作者：Jono, H; Anno, T; Motoyama, K; Misumi, Y; Tasaki, M; Oshima, T; Mori, Y; Mizuguchi, M; Ueda, M; Shono, M; Obayashi, K; Arima, H; Ando, Y,期刊：Biochemical Journal, 页码：35-42 , 文章类型： Article，,卷期：2011年437-Part 1]
- TTR (transthyretin), a beta-sheet-rich protein, is the precursor protein of familial amyloidotic polyneuropathy and senile systemic amyloidosis. Although it has been widely accepted that protein misfolding of the monomer...
- Archaeal flagellar ATPase motor shows ATP-dependent hexameric assembly and activity stimulation by specific lipid binding
[作者：Ghosh, A; Hartung, S; van der Does, C; Tainer, JA; Albers, SV,期刊：Biochemical Journal, 页码：43-52 , 文章类型： Article，,卷期：2011年437-Part 1]
- Microbial motility frequently depends on flagella or type TV pili. Using recently developed archaeal genetic tools, archaeal flagella and its assembly machinery have been identified. Archaeal flagella are functionally si...
- Stereospecific reduction of 5 beta-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5 beta-reductase pathway
[作者：Jin, Y; Mesaros, AC; Blair, IA; Penning, TM,期刊：Biochemical Journal, 页码：53-61 , 文章类型： Article，,卷期：2011年437-Part 1]
- Active sex hormones such as testosterone and progesterone are metabolized to tetrahydrosteroids in the liver to terminate hormone action. One main metabolic pathway, the 5 beta-pathway, involves 5 beta-steroid reductase ...
- Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906
[作者：Soares, DG; Battistella, A; Rocca, CJ; Matuo, R; Henriques, JAP; Larsen, AK; Escargueil, AE,期刊：Biochemical Journal, 页码：63-73 , 文章类型： Article，,卷期：2011年437-Part 1]
- Numerous anticancer agents and environmental mutagens target DNA. Although all such compounds interfere with the progression of the replication fork and inhibit DNA synthesis, there are marked differences in the DNA-dama...
- Repression of the RHOH gene by JunD
[作者：Delestre, L; Berthon, C; Quesnel, B; Figeac, M; Kerckaert, JP; Galiegue-Zouitina, S; Shelley, CS,期刊：Biochemical Journal, 页码：75-88 , 文章类型： Article，,卷期：2011年437-Part 1]
- RhoH is a member of the Rho family of small GTP-binding proteins that lacks GTPase activity. Since RhoH is constantly bound by GTP, it is thought to be constitutively active and controlled predominantly by changes in qua...
- The RNA-binding protein HuR stabilizes survivin mRNA in human oesophageal epithelial cells
[作者：Donahue, JM; Chang, ET; Xiao, L; Wang, PY; Rao, JN; Turner, DJ; Wang, JY; Battafarano, RJ,期刊：Biochemical Journal, 页码：89-96 , 文章类型： Article，,卷期：2011年437-Part 1]
- Overexpression of survivin, a member of the IAP (inhibitor of apoptosis) family, has been correlated with poorer outcomes in multiple malignancies, including oesophageal cancer. The regulatory mechanisms, particularly at...
- Manifold effects of palmitoylcarnitine on endoplasmic reticulum metabolism: 11 beta-hydroxysteroid dehydrogenase 1, flux through hexose-6-phosphate dehydrogenase and NADPH concentration
[作者：Wang, XD; Mick, GJ; Maser, E; McCormick, K,期刊：Biochemical Journal, 页码：109-115 , 文章类型： Article，,卷期：2011年437-Part 1]
- With the exception of the oxidation of G6P (glucose 6-phosphate) by H6PDH (hexose-6-phosphate dehydrogenase), scant information is available about other endogenous substrates affecting the redox state or the regulation o...
- Identification and characterization of interactions between abscisic acid and mitochondrial adenine nucleotide translocators
[作者：Kharenko, OA; Boyd, J; Nelson, KM; Abrams, SR; Loewen, MC,期刊：Biochemical Journal, 页码：117-123 , 文章类型： Article，,卷期：2011年437-Part 1]
- ABA (abscisic acid) is a plant hormone involved in important processes including development and stress responses. Recent reports have identified a number of plant ABA receptors and transporters, highlighting novel mecha...
- FAT/CD36 is located on the outer mitochondrial membrane, upstream of long-chain acyl-CoA synthetase, and regulates palmitate oxidation
[作者：Smith, BK; Jain, SS; Rimbaud, S; Dam, A; Quadrilatero, J; Ventura-Clapier, R; Bonen, A; Holloway, GP,期刊：Biochemical Journal, 页码：125-134 , 文章类型： Article，,卷期：2011年437-Part 1]
- FAT/CD36 (fatty acid translocase/Cluster of Differentiation 36), a plasma membrane fatty-acid transport protein, has been found on mitochondrial membranes; however, it remains unclear where FAT/CD36 resides on this organ...
- ATP binding to the epsilon subunit of thermophilic ATP synthase is crucial for efficient coupling of ATPase and H+ pump activities
[作者：Kadoya, F; Kato, S; Watanabe, K; Kato-Yamada, Y,期刊：Biochemical Journal, 页码：135-140 , 文章类型： Article，,卷期：2011年437-Part 1]
- ATP binding to the a subunit of F-1-ATPase, a soluble subcomplex of TF0F1 (F0F1-ATPase synthase from the thermophilic Bacillus strain PS3), affects the regulation of F-1-ATPase activity by stabilizing the compact, ATPase...
- Characterization of DNA-binding activity in the N-terminal domain of the DNA methyltransferase Dnmt3a
[作者：Suetake, I; Mishima, Y; Kimura, H; Lee, YH; Goto, Y; Takeshima, H; Ikegami, T; Tajima, S,期刊：Biochemical Journal, 页码：141-148 , 文章类型： Article，,卷期：2011年437-Part 1]
- The Dnmt3a gene, which encodes de novo-type DNA methyltransferase, encodes two isoforms, full-length Dnmt3a and Dnmt3a2, which lacks the N-terminal 219 amino acid residues. We found that Dnmt3a showed higher DNA-binding ...
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