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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共21条记录   In VIVO biochemistry: quantifying ion and metabolite levels in individual cells or cultures of yeast [作者：Bermejo, C; Ewald, JC; Lanquar, V; Jones, AM; Frommer, WB,期刊：Biochemical Journal, 页码：1-10 , 文章类型： Review，,卷期：2011年438-Part 1] Over the past decade, we have learned that cellular processes, including signalling and metabolism, are highly compartmentalized, and that relevant changes in metabolic state can occur at sub-second timescales. Moreover,... Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor [作者：Hirai, H; Karian, P; Kikyo, N,期刊：Biochemical Journal, 页码：11-23 , 文章类型： Review，,卷期：2011年438-Part 1] LlF (leukaemia inhibitory factor) is a key cytokine for maintaining self-renewal and pluripotency of mESCs (mouse embryonic stern cells). Upon binding to the LIF receptor, LIF activates three major intracellular signalli... microRNA regulation of expression of the cystic fibrosis transmembrane conductance regulator gene [作者：Gillen, AE; Gosalia, N; Leir, SH; Harris, A,期刊：Biochemical Journal, 页码：25-32 , 文章类型： Article，,卷期：2011年438-Part 1] The CFTR (cystic fibrosis transmembrane conductance regulator) gene shows a complex temporal and spatial pattern of expression that is controlled by multiple cis-acting elements interacting with the basal promoter. Altho... Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK [作者：Jeon, TI; Seo, YK; Osborne, TF,期刊：Biochemical Journal, 页码：33-37 , 文章类型： Article，,卷期：2011年438-Part 1] T2Rs (bitter taste-sensing type 2 receptors) are expressed in the oral cavity to prevent ingestion of dietary toxins through taste avoidance. They are also expressed in other cell types, including gut enteroendocrine cel... Targeting the autolysis loop of urokinase-type plasminogen activator with conformation-specific monoclonal antibodies [作者：Botkjaer, KA; Fogh, S; Bekes, EC; Chen, Z; Blouse, GE; Jensen, JM; Mortensen, KK; Huang, MD; Deryugina, E; Quigley, JP; Declerck, PJ; Andreasen, PA,期刊：Biochemical Journal, 页码：39-51 , 文章类型： Article，,卷期：2011年438-Part 1] Tight regulation of serine proteases is essential for their physiological function, and unbalanced states of protease activity have been implicated in a variety of human diseases. One key example is the presence of uPA (... A drug targeting only p110 alpha can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types [作者：Jamieson, S; Flanagan, JU; Kolekar, S; Buchanan, C; Kendall, JD; Lee, WJ; Rewcastle, GW; Denny, WA; Singh, R; Dickson, J; Baguley, BC; Shepherd, PR,期刊：Biochemical Journal, 页码：53-62 , 文章类型： Article，,卷期：2011年438-Part 1] Genetic alterations in PI3K (phosphoinositide 3-kinase) signalling are common in cancer and include deletions in PTEN (phosphatase and tensin homologue deleted on chromosome 10), amplifications of PIK3CA and mutations in... The Arabidopsis phi class glutathione transferase AtGSTF2: binding and regulation by biologically active heterocyclic ligands [作者：Dixon, DP; Sellars, JD; Edwards, R,期刊：Biochemical Journal, 页码：63-70 , 文章类型： Article，,卷期：2011年438-Part 1] The plant-specific phi class of glutathione transferases (GSTFs) are often highly stress-inducible and expressed in a tissue-specific manner, suggestive of them having important protective roles. To date, these functions... Aldo-keto reductase family 1, member B10 is secreted through a lysosome-mediated non-classical pathway [作者：Luo, DX; Huang, MC; Ma, J; Gao, Z; Liao, DF; Cao, DL,期刊：Biochemical Journal, 页码：71-80 , 文章类型： Article，,卷期：2011年438-Part 1] AKR1B10 (aldo-keto reductase family 1, member B10) protein is primarily expressed in normal human small intestine and colon, but overexpressed in several types of human cancers and considered as a tumour marker. In the p... Exo70, a subunit of the exocyst complex, interacts with SNEVhPrp19/hPso4 and is involved in pre-mRNA splicing [作者：Dellago, H; Loscher, M; Ajuh, P; Ryder, U; Kaisermayer, C; Grillari-Voglauer, R; Fortschegger, K; Gross, S; Gstraunthaler, A; Borth, N; Eisenhaber, F; Lamond, AI; Grillari, J,期刊：Biochemical Journal, 页码：81-91 , 文章类型： Article，,卷期：2011年438-Part 1] The Cdc5L (cell division cycle 5-like) complex is a spliceosomal subcomplex that also plays a role in DNA repair. The complex contains the splicing factor hPrp19, also known as SNEV or hPso4, which is involved in cellula... The DLK gene is a transcriptional target of PPAR gamma [作者：Couture, JP; Blouin, R,期刊：Biochemical Journal, 页码：93-101 , 文章类型： Article，,卷期：2011年438-Part 1] DLK (dual leucine zipper-bearing kinase) is a key regulator of development, cell differentiation and apoptosis. Interestingly, recent studies have shown that DLK expression is up-regulated in 3T3-L1 cells induced to diff... Discovery of cellular substrates for protein kinase A using a peptide array screening protocol [作者：Smith, FD; Samelson, BK; Scott, JD,期刊：Biochemical Journal, 页码：103-110 , 文章类型： Article，,卷期：2011年438-Part 1] Post-translational modification of proteins is a universal form of cellular regulation. Phosphorylation on serine, threonine, tyrosine or histidine residues by protein kinases is the most widespread and versatile form of... Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPAR gamma agonist [作者：Goto, T; Nagai, H; Egawa, K; Kim, YI; Kato, S; Taimatsu, A; Sakamoto, T; Ebisu, S; Hohsaka, T; Miyagawa, H; Murakami, S; Takahashi, N; Kawada, T,期刊：Biochemical Journal, 页码：111-119 , 文章类型： Article，,卷期：2011年438-Part 1] The cholesterol biosynthetic pathway produces not only sterols but also non-sterol mevalonate metabolites involved in isoprenoid synthesis. Mevalonate metabolites affect transcriptional and post-transcriptional events th... Protein network study of human AF4 reveals its central role in RNA Pol II-mediated transcription and in phosphorylation-dependent regulatory mechanisms [作者：Esposito, G; Cevenini, A; Cuomo, A; De Falco, F; Sabbatino, D; Pane, F; Ruoppolo, M; Salvatore, F,期刊：Biochemical Journal, 页码：121-131 , 文章类型： Article，,卷期：2011年438-Part 1] AF4 belongs to a family of proteins implicated in childhood lymphoblastic leukaemia, FRAXE (Fragile X E site) mental retardation and ataxia. AF4 is a transcriptional activator that is involved in transcriptional elongati... Demonstration that endoplasmic reticulum-associated degradation of glycoproteins can occur downstream of processing by endomannosidase [作者：Kukushkin, NV; Alonzi, DS; Dwek, RA; Butters, TD,期刊：Biochemical Journal, 页码：133-142 , 文章类型： Article，,卷期：2011年438-Part 1] During quality control in the ER (endoplasmic reticulum), nascent glycoproteins are deglucosylated by ER glucosidases I and II. In the post-ER compartments, glycoprotein endo-alpha-mannosidase provides an alternative rou... OEP61 is a chaperone receptor at the plastid outer envelope [作者：von Loeffelholz, O; Kriechbaumer, V; Ewan, RA; Jonczyk, R; Lehmann, S; Young, JC; Abell, BM,期刊：Biochemical Journal, 页码：143-153 , 文章类型： Article，,卷期：2011年438-Part 1] Chloroplast precursor proteins encoded in the nucleus depend on their targeting sequences for delivery to chloroplasts. There exist different routes to the chloroplast outer envelope, but a common theme is the involvemen... Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity [作者：Lambert, QT; Pradhan, A; Roll, JD; Reuther, GW,期刊：Biochemical Journal, 页码：155-164 , 文章类型： Article，,卷期：2011年438-Part 1] Cytokines and their receptors regulate haemopoiesis by controlling cellular growth, survival and differentiation. Thus it is not surprising that mutations of cytokine receptors contribute to the formation of haemopoietic...