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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共17条记录   Alternative affinity tools: more attractive than antibodies? [作者：Ruigrok, VJB; Levisson, M; Eppink, MHM; Smidt, H; van der Oost, J,期刊：Biochemical Journal, 页码：1-13 , 文章类型： Review，,卷期：2011年436-Part 1] Antibodies are the most successful affinity tools used today, in both fundamental and applied research (diagnostics, purification and therapeutics). Nonetheless, antibodies do have their limitations, including high produ... The remarkable diversity of plant PEPC (phosphoenolpyruvate carboxylase): recent insights into the physiological functions and post-translational controls of non-photosynthetic PEPCs [作者：O'Leary, B; Park, J; Plaxton, WC,期刊：Biochemical Journal, 页码：15-34 , 文章类型： Review，,卷期：2011年436-Part 1] PEPC [PEP (phosphoenolpyruvate) carboxylase] is a tightly controlled enzyme located at the core of plant C-metabolism that catalyses the irreversible beta-carboxylation of PEP to form oxaloacetate and P-i. The critical r... Different domains are critical for oligomerization compatibility of different connexins [作者：Martinez, AD; Maripillan, J; Acuna, R; Minogue, PJ; Berthoud, VM; Beyer, EC,期刊：Biochemical Journal, 页码：35-43 , 文章类型： Article，,卷期：2011年436-Part 1] Oligomerization of connexins is a critical step in gap junction channel formation. Some members of the connexin family can oligomerize with other members and form functional heteromeric hemichannels [e.g. Cx43 (connexin ... Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis [作者：Veltman, DM; Auciello, G; Spence, HJ; Machesky, LM; Rappoport, JZ; Insall, RH,期刊：Biochemical Journal, 页码：45-52 , 文章类型： Article，,卷期：2011年436-Part 1] I-BAR (inverse-Bin/amphiphysin/Rvs)-domain-containing proteins such as IRSp53 (insulin receptor substrate of 53 kDa) associate with outwardly curved membranes and connect them to proteins involved in actin dynamics. Rese... Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide [作者：Akif, M; Schwager, SL; Anthony, CS; Czarny, B; Beau, F; Dive, V; Sturrock, ED; Acharya, KR,期刊：Biochemical Journal, 页码：53-59 , 文章类型： Article，,卷期：2011年436-Part 1] Human ACE (angiotensin-I-converting enzyme) has long been regarded as an excellent target for the treatment of hypertension and related cardiovascular diseases. Highly potent inhibitors have been developed and are extens... Function of the CysD domain of the gel-forming MUC2 mucin [作者：Ambort, D; van der Post, S; Johansson, MEV; MacKenzie, J; Thomsson, E; Krengel, U; Hansson, GC,期刊：Biochemical Journal, 页码：61-70 , 文章类型： Article，,卷期：2011年436-Part 1] The colonic human MUC2 mucin forms a polymeric gel by covalent disulfide bonds in its N- and C-termini. The middle part of MUC2 is largely composed of two highly O-glycosylated mucin domains that are interrupted by a Cys... Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model [作者：Wheldon, LM; Khodabukus, N; Patey, SJ; Smith, TG; Heath, JK; Hajihosseini, MK,期刊：Biochemical Journal, 页码：71-81 , 文章类型： Article，,卷期：2011年436-Part 1] AS (Apert syndrome) is a congenital disease composed of skeletal, visceral and neural abnormalities, caused by dominant-acting mutations in FGFR2 [FGF (fibroblast growth factor) receptor 2]. Multiple FGFR2 splice variant... Solution structure of the Taf14 YEATS domain and its roles in cell growth of Saccharomyces cerevisiae [作者：Zhang, W; Zhang, JH; Zhang, XC; Xu, C; Tu, XM,期刊：Biochemical Journal, 页码：83-90 , 文章类型： Article，,卷期：2011年436-Part 1] Chromatin modifications play important roles in cellular biological process. A novel conserved domain family, YEATS, has been discovered in a variety of eukaryotic species ranging from yeasts to humans. Taf14, which is i... Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response [作者：Bourquard, N; Ng, CJ; Reddy, ST,期刊：Biochemical Journal, 页码：91-100 , 文章类型： Article，,卷期：2011年436-Part 1] Hepatic glucose metabolism is strongly influenced by oxidative stress and pro-inflammatory stimuli. PON2 (paraoxonase 2), an enzyme with undefined antioxidant properties, protects against atherosclerosis. PON2-deficient ... Assembly states of the nucleosome assembly protein 1 (NAP-1) revealed by sedimentation velocity and non-denaturing MS [作者：Noda, M; Uchiyama, S; McKay, AR; Morimoto, A; Misawa, S; Yoshida, A; Shimahara, H; Takinowaki, H; Nakamura, S; Kobayashi, Y; Matsunaga, S; Ohkubo, T; Robinson, CV; Fukui, K,期刊：Biochemical Journal, 页码：101-112 , 文章类型： Article，,卷期：2011年436-Part 1] Proteins often exist as ensembles of interconverting states in solution which are often difficult to quantify. In the present manuscript we show that the combination of MS under non-denaturing conditions and AUC-SV (anal... Analysis of myotilin turnover provides mechanistic insight into the role of myotilinopathy-causing mutations [作者：von Nandelstadh, P; Soliymani, R; Baumann, M; Carpen, O,期刊：Biochemical Journal, 页码：113-121 , 文章类型： Article，,卷期：2011年436-Part 1] MFM (myofibrillar myopathies) are caused by mutations in several sarcomeric components, including. the Z-disc protein myotilin. The morphological changes typical of MFM include Z-disc alterations and aggregation of dense... Mitochondrial protection by the thioredoxin-2 and glutathione systems in an in vitro endothelial model of sepsis [作者：Lowes, DA; Galley, HF,期刊：Biochemical Journal, 页码：123-132 , 文章类型： Article，,卷期：2011年436-Part 1] Oxidative stress and mitochondrial dysfunction are common features in patients with sepsis and organ failure. Within mitochondria, superoxide is converted into hydrogen peroxide by MnSOD (manganese-containing superoxide ... Adhesion-dependent Skp2 transcription requires selenocysteine tRNA gene transcription-activating factor (STAF) [作者：Hernandez-Negrete, I; Sala-Newby, GB; Perl, A; Kunkel, GR; Newby, AC; Bond, M,期刊：Biochemical Journal, 页码：133-143 , 文章类型： Article，,卷期：2011年436-Part 1] Cell adhesion is essential for cell cycle progression in most normal cells. Loss of adhesion dependence is a hallmark of cellular transformation. The F-box protein Skp2 (S-phase kinase-associated protein 2) controls G(1)... The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors [作者：Parsons, RB; Aravindan, S; Kadampeswaran, A; Evans, EA; Sandhu, KK; Levy, ER; Thomas, MG; Austen, BM; Ramsden, DB,期刊：Biochemical Journal, 页码：145-155 , 文章类型： Article，,卷期：2011年436-Part 1] NNMT (nicotinamide N-methyltransferase, E.C. 2.1.1.1) catalyses the N-methylation of nicotinamide to 1-methylnicotinamide. NNMT expression is significantly elevated in a number of cancers, and we have previously demonstr... hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain [作者：Vos, LJ; Famulski, JK; Chan, GKT,期刊：Biochemical Journal, 页码：157-168 , 文章类型： Article，,卷期：2011年436-Part 1] Accurate chromosome segregation in mitosis is required to maintain genetic stability. hZwint-1 [human Zw10 (Zeste white 10)-interacting protein 1] is a kinetochore protein known to interact with the kinetochore checkpoin... Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney [作者：Pearce, LR; Sommer, EM; Sakamoto, K; Wullschleger, S; Alessi, DR,期刊：Biochemical Journal, 页码：169-179 , 文章类型： Article，,卷期：2011年436-Part 1] The mTOR (mammalian target of rapamycin) protein kinase is an important regulator of cell growth and is a key target for therapeutic intervention in cancer. Two complexes of mTOR have been identified: complex 1 (mTORC1),...