- Computational Design of Membrane Proteins
[作者：Perez-Aguilar, JM; Saven, JG,期刊：Structure, 页码：5-14 , 文章类型： Article，,卷期：2012年20-1]
- Membrane proteins are involved in a wide variety of cellular processes, and are typically part of the first interaction a cell has with extracellular molecules. As a result, these proteins comprise a majority of known dr...
- NMR Structure of a Heterodimeric SAM:SAM Complex: Characterization and Manipulation of EphA2 Binding Reveal New Cellular Functions of SHIP2
[作者：Lee, HJ; Hota, PK; Chugha, P; Guo, H; Miao, H; Zhang, LQ; Kim, SJ; Stetzik, L; Wang, BC; Buck, M,期刊：Structure, 页码：41-55 , 文章类型： Article，,卷期：2012年20-1]
- The sterile alpha motif (SAM) for protein-protein interactions is encountered in over 200 proteins, but the structural basis for its interactions is just becoming clear. Here we solved the structure of the EphA2-SHIP2 SA...
- Mechanism of Regulation of Receptor Histidine Kinases
[作者：Ferris, HU; Dunin-Horkawicz, S; Hornig, N; Hulko, M; Martin, J; Schultz, JE; Zeth, K; Lupas, AN; Colest, M,期刊：Structure, 页码：56-66 , 文章类型： Article，,卷期：2012年20-1]
- Bacterial transmembrane receptors regulate an intracellular catalytic output in response to extracellular sensory input. To investigate the conformational changes that relay the regulatory signal, we have studied the HAM...
- Protein Domain Structure Uncovers the Origin of Aerobic Metabolism and the Rise of Planetary Oxygen
[作者：Kim, KM; Qin, T; Jiang, YY; Chen, LL; Xiong, M; Caetano-Anolles, D; Zhang, HY; Caetano-Anolles, G,期刊：Structure, 页码：67-76 , 文章类型： Article，,卷期：2012年20-1]
- The origin and evolution of modern biochemistry remain a mystery despite advances in evolutionary bioinformatics. Here, we use a structural census in nearly 1,000 genomes and a molecular clock of folds to define a timeli...
- The Alternatively Spliced Acid Box Region Plays a Key Role in FGF Receptor Autoinhibition
[作者：Kalinina, J; Dutta, K; Ilghari, D; Beenken, A; Goetz, R; Eliseenkova, AV; Cowburn, D; Mohammadi, M,期刊：Structure, 页码：77-88 , 文章类型： Article，,卷期：2012年20-1]
- Uncontrolled fibroblast growth factor (FGF) signaling can lead to human malignancies necessitating multiple layers of self-regulatory control mechanisms. Fibroblast growth factor receptor (FGFR) autoinhibition mediated b...
- Structure of the Yersinia pestis FabV Enoyl-ACP Reductase and Its Interaction with Two 2-Pyridone Inhibitors
[作者：Hirschbeck, MW; Kuper, J; Lu, H; Liu, N; Neckles, C; Shah, S; Wagner, S; Sotriffer, CA; Tonge, PJ; Kisker, C,期刊：Structure, 页码：89-100 , 文章类型： Article，,卷期：2012年20-1]
- The recently discovered FabV enoyl-ACP reductase, which catalyzes the last step of the bacterial fatty acid biosynthesis (FAS-II) pathway, is a promising but unexploited drug target against the reemerging pathogen Yersin...
- Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824
[作者：Cellitti, SE; Shaffer, J; Jones, DH; Mukherjee, T; Gurumurthy, M; Bursulaya, B; Boshoff, HI; Choi, I; Nayyar, A; Lee, YS; Cherian, J; Niyomrattanakit, P; Dick, T; Manjunatha, UH; Barry, CE; Spraggon, G; Geierstanger, BH,期刊：Structure, 页码：101-112 , 文章类型： Article，,卷期：2012年20-1]
- Tuberculosis continues to be a global health threat, making bicyclic nitroimidazoles an important new class of therapeutics. A deazaflavin-dependent nitroreductase (Ddn) from Mycobacterium tuberculosis catalyzes the redu...
- Computational Reconstruction of Multidomain Proteins Using Atomic Force Microscopy Data
[作者：Trinh, MH; Odorico, M; Pique, ME; Teulon, JM; Roberts, VA; Ten Eyck, LF; Getzoff, ED; Parot, P; Chen, SWW; Pellequer, JL,期刊：Structure, 页码：113-120 , 文章类型： Article，,卷期：2012年20-1]
- Classical structural biology techniques face a great challenge to determine the structure at the atomic level of large and flexible macromolecules. We present a novel methodology that combines high-resolution AFM topogra...
- The Transmembrane Protein KpOmpA Anchoring the Outer Membrane of Klebsiella pneumoniae Unfolds and Refolds in Response to Tensile Load
[作者：Bosshart, PD; Iordanov, I; Garzon-Coral, C; Demange, P; Engel, A; Milon, A; Muller, DJ,期刊：Structure, 页码：121-127 , 文章类型： Article，,卷期：2012年20-1]
- In Klebsiella pneumoniae the transmembrane beta-barrel forming outer membrane protein KpOmpA mediates adhesion to a wide range of immune effector cells, thereby promoting respiratory tract and urinary infections. As majo...
- Ligand and Receptor Dynamics Contribute to the Mechanism of Graded PPAR gamma Agonism
[作者：Hughes, TS; Chalmers, MJ; Novick, S; Kuruvilla, DS; Chang, MR; Kamenecka, TM; Rance, M; Johnson, BA; Burris, TP; Griffin, PR; Kojetin, DJ,期刊：Structure, 页码：139-150 , 文章类型： Article，,卷期：2012年20-1]
- Ligand binding to proteins is not a static process, but rather involves a number of complex dynamic transitions. A flexible ligand can change conformation upon binding its target. The conformation and dynamics of a prote...
- Structural Basis for Molecular Interactions Involving MRG Domains: Implications in Chromatin Biology
[作者：Xie, T; Graveline, R; Kumar, GS; Zhang, YB; Krishnan, A; David, G; Radhakrishnan, I,期刊：Structure, 页码：151-160 , 文章类型： Article，,卷期：2012年20-1]
- MRG15 is a member of the mortality family of transcription factors that targets a wide variety of multiprotein complexes involved in transcription regulation, DNA repair, and alternative splicing to chromatin. The struct...
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