- Irinophore C (TM), a lipid-based nanoparticulate formulation of irinotecan, is more effective than free irinotecan when used to treat an orthotopic glioblastoma model
[作者:Verreault, M; Strutt, D; Masin, D; Anantha, M; Waterhouse, D; Yapp, DT; Bally, MB,期刊:Journal of controlled release, 页码:34-43 , 文章类型: Article,,卷期:2012年158-1]
- Given compelling evidences supporting the therapeutic potential of irinotecan (IRN) for patients with glioblastoma (GBM), the present study evaluated the activity of Irinophore C (TM) (IrC (TM)), a lipid-based nanopharma...
- Synthesis, characterization and evaluation of bone targeting salmon calcitonin analogs in normal and osteoporotic rats
[作者:Bhandari, KH; Newa, M; Chapman, J; Doschak, MR,期刊:Journal of controlled release, 页码:44-52 , 文章类型: Article,,卷期:2012年158-1]
- In order to assess the therapeutic efficacy of an antiresorptive drug with imparted bone targeting potential using bisphosphonate (BP) conjugation and an improved pharmacokinetic profile using PEGylation, we synthesized,...
- Low melting point amphiphilic microspheres for delivery of bone morphogenetic protein-6 and transforming growth factor-beta 3 in a hydrogel matrix
[作者:Sukarto, A; Amsden, BG,期刊:Journal of controlled release, 页码:53-62 , 文章类型: Article,,卷期:2012年158-1]
- Low melting-point poly(1,3-trimethylene carbonate-co-epsilon-caprolactone)-b-poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate-co-epsilon-caprolactone), P(TMC-CL)(2)-PEG, was employed to fabricate microspheres for ...
- In vitro and in vivo assessment of targeting lipid-based nanoparticles to the epidermal growth factor-receptor (EGFR) using a novel Heptameric Z(EGFR) domain
[作者:Benhabbour, SR; Luft, JC; Kim, D; Jain, A; Wadhwa, S; Parrott, MC; Liu, RH; DeSimone, JM; Mumper, RJ,期刊:Journal of controlled release, 页码:63-71 , 文章类型: Article,,卷期:2012年158-1]
- Lipid-based oil-filled nanoparticles (NPs) with a high concentration of surface-chelated nickel (Ni-NPs) were successfully prepared using a Brij 78-NTA-Ni conjugate synthesized with Brij 78 (Polyoxyethylene (20) stearyl ...
- Rapid kinetics to peak serum antibodies is achieved following influenza vaccination by dry-coated densely packed microprojections to skin
[作者:Chen, XF; Fernando, GJP; Raphael, AP; Yukiko, SR; Fairmaid, EJ; Primiero, CA; Frazer, IH; Brown, LE; Kendall, MAF,期刊:Journal of controlled release, 页码:78-84 , 文章类型: Article,,卷期:2012年158-1]
- A rapid time to peak serum antibody response following vaccination is particularly important for influenza: the time window between the availability of appropriate antigen and the start of the seasonal epidemic is very s...
- Fluorescent penetration enhancers for transdermal applications
[作者:Seto, JE; Polat, BE; VanVeller, B; Lopez, RFV; Langer, R; Blankschtein, D,期刊:Journal of controlled release, 页码:85-92 , 文章类型: Article,,卷期:2012年158-1]
- Chemical penetration enhancers are often used to enhance transdermal drug delivery. However, the fundamental mechanisms that govern the interactions between penetration enhancers and skin are not fully understood. Theref...
- EphA2 targeting peptide tethered bioreducible poly(cystamine bisacrylamide-diamino hexane) for the delivery of therapeutic pCMV-RAE-1 gamma to pancreatic islets
[作者:Blevins, KS; Jeong, JH; Ou, M; Brumbach, JH; Kim, SW,期刊:Journal of controlled release, 页码:115-122 , 文章类型: Article,,卷期:2012年158-1]
- The pathogenesis of type-1 diabetes is complicated, and a clear, single mechanism has yet to be identified. Reports have indicated that the activating receptor NKG2D plays an important role in the development of disease....
- Polyethyleneimine-Based Core-Shell Nanogels: A Promising siRNA Carrier for Argininosuccinate Synthetase mRNA Knockdown in HeLa Cells
[作者:Mimi, H; Ho, KM; Siu, YS; Wu, AH; Li, P,期刊:Journal of controlled release, 页码:123-130 , 文章类型: Article,,卷期:2012年158-1]
- RNA interference using small interfering RNA (siRNA) is a promising biological strategy for treatment of diverse diseases; however, application of siRNA is severely hindered by its poor stability and low cellular uptake ...
- Dexamethasone-loaded peptide micelles for delivery of the heme oxygenase-1 gene to ischemic brain
[作者:Lee, J; Hyun, H; Kim, J; Ryu, JH; Kim, HA; Park, JH; Lee, M,期刊:Journal of controlled release, 页码:131-138 , 文章类型: Article,,卷期:2012年158-1]
- The R3V6 peptides, which are composed of a 3-arginine block and a 6-valine block, formed self-assembled micelles in aqueous solution. Dye quenching assays showed that a hydrophobic fluorescent dye, 5-dodecanoylaminofluor...
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