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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   Acadesine. 5 '-AMP-activated protein kinase activator, Apoptosis inducer, Oncolytic [作者：Campas-Moya, C,期刊：Drugs of the Future, 页码：567-576 , 文章类型： Article，,卷期：2011年36-8] Acadesine (AICA-riboside, Acadra (R)) is a well-known small molecule produced by either chemical synthesis or bacterial fermentation. It has undergone extensive clinical development for cardiovascular disorders but never... Lu-AA-21004. 5-HT(3/7) receptor antagonist, 5-HT(1A) receptor agonist, 5-HT(1B) receptor partial agonist, 5-HT transporter inhibitor, Treatment of depression, Treatment of anxiety [作者：Haddley, K,期刊：Drugs of the Future, 页码：577-584 , 文章类型： Article，,卷期：2011年36-8] Major depressive disorder is one of the leading causes of disability worldwide. Current treatments for depression mostly target the serotonin (5-HT) signaling pathways because decreased concentrations of 5-HT, a major re... SB-509. Zinc finger DNA-binding protein transcription factor activator, VEGF-A upregulator, Treatment of amyotrophic lateral sclerosis, Treatment of diabetic neuropathy [作者：Rendell, M,期刊：Drugs of the Future, 页码：585-588 , 文章类型： Article，,卷期：2011年36-8] SB-509 is a zinc finger DNA-binding protein transcription factor (ZFP-TF) activator that upregulates the expression of vascular endothelial growth factor A (VEGF-A). VEGF-A plays an important role in both angiogenesis an... PROSPECTS IN NASAL VACCINATION AGAINST CLINICALLY RELEVANT PATHOGENS AND SELECT AGENTS [作者：Hickey, AJ; Wilson-Welder, JH; Metzger, DW,期刊：Drugs of the Future, 页码：589-599 , 文章类型： Review，,卷期：2011年36-8] Intranasal immunization induces mucosal immune responses in both the respiratory system and at other distant mucosal surfaces, as well as systemic immune responses. However, most vaccines are still given via the parenter... RECENT ADVANCES IN POSITRON EMISSION TOMOGRAPHY IMAGING OF BRAIN [作者：Seneca, N,期刊：Drugs of the Future, 页码：601-613 , 文章类型： Review，,卷期：2011年36-8] Positron emission tomography (PET) has been widely used to non-invasively study various functions of the brain, the pathophysiology of disease and aid in drug development. PET and selective radiolabeled molecules allow i... TARGETED ANTITUMOR THERAPY WITH THE SCORPION VENOM CHLOROTOXIN [作者：Mamelak, AN,期刊：Drugs of the Future, 页码：615-625 , 文章类型： Review，,卷期：2011年36-8] Chlorotoxin (CTX) is a 36-amino-acid neurotoxin isolated from the venom of the giant yellow Israeli scorpion Leiurus quinquestriatus. The peptide preferentially binds to human malignancies, but not to normal human tissue... THERAPEUTIC TARGETS FOR CANDIDIASIS [作者：Sorbera, LA; Aravamudan, J; Rosa, E,期刊：Drugs of the Future, 页码：627-630 , 文章类型： Article，,卷期：2011年36-8] The incidence of infections caused by Candida species (i.e., candidiasis) has markedly increased in recent years due in part to the expanding population of immunocompromised individuals. Current treatment options for can...