- Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras
[作者：Friedlander, SYG; Chu, GC; Snyder, EL; Girnius, N; Dibelius, G; Crowley, D; Vasile, E; DePinho, RA; Jacks, T,期刊：Cancer Cell, 页码：379-389 , 文章类型： Article，,卷期：2009年16-5]
- Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we determined the effect of PDAC-relevant gene mutations in distinct cell types ...
- Hematopoietic Stem Cell Expansion Precedes the Generation of Committed Myeloid Leukemia-initiating Cells in C/EBP alpha Mutant AML
[作者：Bereshchenko, O; Mancini, E; Moore, S; Bilbao, D; Mansson, R; Luc, S; Grover, A; Jacobsen, SEW; Bryder, D; Nerlov, C,期刊：Cancer Cell, 页码：390-400 , 文章类型： Article，,卷期：2009年16-5]
- We here use knockin mutagenesis in the mouse to model the spectrum of acquired CEBPA mutations in human acute myeloid leukemia. We find that C-terminal C/EBP alpha mutations increase the proliferation of long-term hemato...
- AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance
[作者：O'Hare, T; Shakespeare, WC; Zhu, XT; Eide, CA; Rivera, VM; Wang, F; Adrian, LT; Zhou, TJ; Huang, WS; Xu, QH; Metcalf, CA; Tyner, JW; Loriaux, MM; Corbin, AS; Wardwell, S; Ning, YY; Keats, JA; Wang, YH; Sundaramoorthi, R; Thomas, M; Zhou, D; Snodgrass, J; Commodore, L; Sawyer, TK; Dalgarno, DC; Deininger, MWN; Druker, BJ; Clackson, T,期刊：Cancer Cell, 页码：401-412 , 文章类型： Article，,卷期：2009年16-5]
- Inhibition of BCR-ABL by imatinib induces durable responses in many patients with chronic myeloid leukemia (CML), but resistance attributable to kinase domain mutations can lead to relapse and a switch to second-line the...
- Control of Cyclin D1 and Breast Tumorigenesis by the EgIN2 Prolyl Hydroxylase
[作者：Zhang, Q; Gu, JM; Li, LJ; Liu, JY; Luo, B; Cheung, HW; Boehm, JS; Ni, M; Geisen, C; Root, DE; Polyak, K; Brown, M; Richardson, AL; Hahn, WC; Kaelin, WG; Bommi-Reddy, A,期刊：Cancer Cell, 页码：413-424 , 文章类型： Article，,卷期：2009年16-5]
- 2-Oxoglutarate-dependent dioxygenases, including the EgIN prolyl hydroxylases that regulate HIF, can be inhibited with drug-like molecules. EgIN2 is estrogen inducible in breast carcinoma cells and the lone Drosophila Eg...
- Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene
[作者：Zhou, DW; Conrad, C; Xia, F; Park, JS; Payer, B; Yin, Y; Lauwers, GY; Thasler, W; Lee, JT; Avruch, J; Bardeesy, N,期刊：Cancer Cell, 页码：425-438 , 文章类型： Article，,卷期：2009年16-5]
- Hippo-Lats-Yorkie signaling regulates tissue overgrowth and tumorigenesis in Drosophila. We show that the Mst1 and Mst2 protein kinases, the mammalian Hippo orthologs, are cleaved and constitutively activated in the mous...
- p53-Dependent Translational Control of Senescence and Transformation via 4E-BPs
[作者：Petroulakis, E; Parsyan, A; Dowling, RJO; LeBacquer, O; Martineau, Y; Bidinosti, M; Larsson, O; Alain, T; Rong, LW; Mamane, Y; Paquet, M; Furic, L; Topisirovic, I; Shahbazian, D; Livingstone, M; Costa-Mattioli, M; Teodoro, JG; Sonenberg, N,期刊：Cancer Cell, 页码：439-446 , 文章类型： Article，,卷期：2009年16-5]
- eIF4E, the mRNA 5' cap-binding translation initiation factor, is overexpressed in numerous cancers and is implicated in mechanisms underlying oncogenesis and senescence. 4E-BPs (eIF4E-binding proteins) inhibit eIF4E acti...
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