- Somatic Mutations in p85 alpha Promote Tumorigenesis through Class IA PI3K Activation
[作者：Jaiswal, BS; Janakiraman, V; Kljavin, NM; Chaudhuri, S; Stern, HM; Wang, WR; Kan, ZY; Dbouk, HA; Peters, BA; Waring, P; Dela Vega, T; Kenski, DM; Bowman, KK; Lorenzo, M; Li, H; Wu, JS; Modrusan, Z; Stinson, J; Eby, M; Yue, P; Kaminker, JS; de Sauvage, FJ; Backer, JM; Seshagiri, S,期刊：Cancer Cell, 页码：463-474 , 文章类型： Article，,卷期：2009年16-6]
- Members of the mammalian phosphoinositide-3-OH kinase (PI3K) family of proteins are critical regulators of various cellular process including cell survival, growth, proliferation, and motility. Oncogenic activating mutat...
- The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors
[作者：Hedvat, M; Huszar, D; Herrmann, A; Gozgit, JM; Schroeder, A; Sheehy, A; Buettner, R; Proia, D; Kowolik, CM; Xin, H; Armstrong, B; Bebernitz, G; Weng, SB; Wang, L; Ye, MW; McEachern, K; Chen, HW; Morosini, D; Bell, K; Alimzhanov, M; Ioannidis, S; McCoon, P; Cao, ZA; Yu, H; Jove, R; Zinda, M,期刊：Cancer Cell, 页码：487-497 , 文章类型： Article，,卷期：2009年16-6]
- Persistent activation of Stat3 is oncogenic and is prevalent in a wide variety of human cancers. Chronic cytokine stimulation is associated with Stat3 activation in some tumors, implicating cytokine receptor-associated J...
- miR-221&222 Regulate TRAIL Resistance and Enhance Tumorigenicity through PTEN and TIMP3 Downregulation
[作者：Garofalo, M; Di Leva, G; Romano, G; Nuovo, G; Suh, SS; Ngankeu, A; Taccioli, C; Pichiorri, F; Alder, H; Secchiero, P; Gasparini, P; Gonelli, A; Costinean, S; Acunzo, M; Condorelli, G; Croce, CM,期刊：Cancer Cell, 页码：498-509 , 文章类型： Article，,卷期：2009年16-6]
- Lung and liver cancers are among the most deadly types of cancer. Despite improvements in treatment over the past few decades, patient survival remains poor, underlining the need for development of targeted therapies. Mi...
- Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors
[作者：Sugahara, KN; Teesalu, T; Karmali, PP; Kotamraju, VR; Agemy, L; Girard, OM; Hanahan, D; Mattrey, RF; Ruoslahti, E,期刊：Cancer Cell, 页码：510-520 , 文章类型： Article，,卷期：2009年16-6]
- Poor penetration of drugs into tumors is a major obstacle in tumor treatment. We describe a strategy for peptide-mediated delivery of compounds deep into the tumor parenchyma that uses a tumor-homing peptide, iRGD (CRGDK...
- A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor: Microfibril-Associated Glycoprotein 2
[作者：Mok, SC; Bonome, T; Vathipadiekal, V; Bell, A; Johnson, ME; Wong, KK; Park, DC; Hao, K; Yip, DKP; Donninger, H; Ozbun, L; Samimi, G; Brady, J; Randonovich, M; Pise-Masison, CA; Barrett, JC; Wong, WH; Welch, WR; Berkowitz, RS; Birrer, MJ,期刊：Cancer Cell, 页码：521-532 , 文章类型： Article，,卷期：2009年16-6]
- Advanced stage papillary serous tumors of the ovary are responsible for the majority of ovarian cancer deaths, yet the molecular determinants modulating patient survival are poorly characterized. Here, we identify and va...
- Frequent Amplification of a chr19q13.41 MicroRNA Polycistron in Aggressive Primitive Neuroectodermal Brain Tumors
[作者：Li, MH; Lee, KF; Lu, YT; Clarke, I; Shih, D; Eberhart, C; Collins, VP; Van Meter, T; Picard, D; Zhou, LM; Boutros, PC; Modena, P; Liang, ML; Scherer, SW; Bouffet, E; Rutka, JT; Pomeroy, SL; Lau, CC; Taylor, MD; Gajjar, A; Dirks, PB; Hawkins, CE; Huang, A,期刊：Cancer Cell, 页码：533-546 , 文章类型： Article，,卷期：2009年16-6]
- We discovered a high-level amplicon involving the chr19q13.41 microRNA (miRNA) cluster (C19MC) in 11/45 (similar to 25%) primary CNS-PNET, which results in striking overexpression of miR-517c and 520g. Constitutive expre...
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