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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共13条记录   Rb Regulates DNA Damage Response and Cellular Senescence through E2F-Dependent Suppression of N-Ras Isoprenylation [作者：Shamma, A; Takegami, Y; Miki, T; Kitajima, S; Noda, M; Obara, T; Okamoto, T; Takahashi, C,期刊：Cancer Cell, 页码：255-269 , 文章类型： Article，,卷期：2009年15-4] Oncogene-induced cellular senescence is well documented, but little is known about how infinite cell proliferation induced by loss of tumor suppressor genes is antagonized by cellular functions. Rb heterozygous mice gene... Regulation of Androgen Receptor Transcriptional Activity and Specificity by RNF6-induced Ubiquitination [作者：Xu, KX; Shimelis, H; Linn, DE; Jiang, RC; Yang, X; Sun, F; Guo, ZY; Chen, HG; Li, W; Chen, HG; Kong, XT; Melamed, J; Fang, SY; Xiao, Z; Veenstra, TD; Qiu, Y,期刊：Cancer Cell, 页码：270-282 , 文章类型： Article，,卷期：2009年15-4] The androgen receptor (AR) plays a critical role in prostate cancer. We have identified a ubiquitin E3 ligase, RNF6, as an AR-associated protein in a proteomic screen. RNF6 induces AR ubiquitination and promotes AR trans... Persistently Activated Stat3 Maintains Constitutive NF-kappa B Activity in Tumors [作者：Lee, H; Herrmann, A; Deng, JH; Kujawski, M; Niu, GL; Li, ZW; Forman, S; Jove, R; Pardoll, DM; Yu, H,期刊：Cancer Cell, 页码：283-293 , 文章类型： Article，,卷期：2009年15-4] NF-kappa B (ReIA) is constitutively active in many cancers, where it upregulates antiapoptotic and other oncogenic genes. While proinflammatory stimulus-induced NF-kappa B activation involves IKK-dependent nuclear transl... Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice [作者：Dhomen, N; Reis-Filho, JS; Dias, SD; Hayward, R; Savage, K; Delmas, V; Larue, L; Pritchard, C; Marais, R,期刊：Cancer Cell, 页码：294-303 , 文章类型： Article，,卷期：2009年15-4] We show here that inducible expression of Braf(V600E) off the endogenous Braf gene in mouse melanocytes stimulates skin hyperpigmentation and the appearance of nevi harboring senescent melanocytes. Additionally, approxim... Rak Functions as a Tumor Suppressor by Regulating PTEN Protein Stability and Function [作者：Yim, EK; Peng, G; Dai, H; Hu, RZ; Li, KY; Lu, W; Mills, GB; Meric-Bernstam, F; Hennessy, BT; Craven, RJ; Lin, SY,期刊：Cancer Cell, 页码：304-314 , 文章类型： Article，,卷期：2009年15-4] Expression of the PTEN tumor suppressor is frequently lost in breast cancer in the absence of mutation or promoter methylation through as yet undetermined mechanisms. In this study, we demonstrate that the Rak tyrosine k... TGF-beta Increases Glioma-Initiating Cell Self-Renewal through the Induction of LIF in Human Glioblastoma [作者：Penuelas, S; Anido, J; Prieto-Sanchez, RM; Folch, G; Barba, I; Cuartas, I; Garcia-Dorado, D; Poca, MA; Sahuquillo, J; Baselga, J; Seoane, J,期刊：Cancer Cell, 页码：315-327 , 文章类型： Article，,卷期：2009年15-4] Glioma-initiating cells (GICs) are responsible for the initiation and recurrence of gliomas. Here, we identify a molecular mechanism that regulates the self-renewal capacity of patient-derived GICs. We show that TGF-beta... Lessons Learned from the Study of JunB: New Insights for Normal and Leukemia Stem Cell Biology [作者：Guzman, ML; Jordan, CT,期刊：Cancer Cell, 页码：252-254 , 文章类型： Editorial Material，,卷期：2009年15-4] JunB is important in maintaining normal hematopoietic stem cell functions, but the mechanisms underlying its activity are not well understood. In the current issue of Cancer Cell, a study by Santaguida et al. provides ne... ZNF423 Is Critically Required for Retinoic Acid-induced Differentiation and Is a Marker of Neuroblastoma Outcome [作者：Huang, SD; Laoukili, J; Epping, MT; Koster, J; Holzel, M; Westerman, BA; Nijkamp, W; Hata, A; Asgharzadeh, S; Seeger, RC; Versteeg, R; Beijersbergen, RL; Bernards, R,期刊：Cancer Cell, 页码：328-340 , 文章类型： Article，,卷期：2009年15-4] Retinoids play key roles in differentiation, growth arrest, and apoptosis and are increasingly being used in the clinic for the treatment of a variety of cancers, including neuroblastoma. Here, using a large-scale RNA in... JunB Protects against Myeloid Malignancies by Limiting Hematopoietic Stem Cell Proliferation and Differentiation without Affecting Self-Renewal [作者：Santaguida, M; Schepers, K; King, B; Sabnis, AJ; Forsberg, EC; Attema, JL; Braun, BS; Passegue, E,期刊：Cancer Cell, 页码：341-352 , 文章类型： Article，,卷期：2009年15-4] Loss of the JunB/AP-1 transcription factor induces a myeloproliferative disease (MPD) arising from the hematopoietic stem cell (HSC) compartment. Here, we show that junB inactivation deregulates the cell-cycle machinery ... Ras and pRb: The Relationship Gets Yet More Intimate [作者：Peeper, DS,期刊：Cancer Cell, 页码：243-245 , 文章类型： Editorial Material，,卷期：2009年15-4] Ras and pRb are key regulators of a plethora of cellular processes, including proliferation, differentiation, and tumorigenesis. Adding to several previously established lines of communication between the two, in this is... Unraveling the Complexities of Androgen Receptor Signaling in Prostate Cancer Cells [作者：Heemers, HV; Tindall, DJ,期刊：Cancer Cell, 页码：245-247 , 文章类型： Editorial Material，,卷期：2009年15-4] Androgen signaling is critical for proliferation of prostate cancer cells but cannot be fully inhibited by current androgen deprivation therapies. A study by Xu et al. in this issue of Cancer Cell provides insights into ... Glioma Stem Cells: Not All Created Equal [作者：Fine, HA,期刊：Cancer Cell, 页码：247-249 , 文章类型： Editorial Material，,卷期：2009年15-4] A growing body of evidence suggests that only a small subpopulation of malignant glioma cells have true tumorigenic potential. A study by Penuelas et al. in this issue of Cancer Cell demonstrates that TGF-beta can stimul... Fingering Modulators of Retinoic Acid Signaling Identifies New Prognostic Marker for Neuroblastoma [作者：Gronemeyer, H; Zelent, A,期刊：Cancer Cell, 页码：249-251 , 文章类型： Editorial Material，,卷期：2009年15-4] Properly designed genome-wide screening strategies can provide new insights into biological processes and/or biomarkers for malignant diseases. In this issue of Cancer Cell, Huang et al. demonstrate that the Kruppel zinc...