- Current Strategies for the Discovery of K+ Channel Modulators
[作者:Ye, DJ; Wang, J; Yu, KQ; Zhou, Y; Jiang, HL; Chen, KX; Liu, H,期刊:Current Topics in Medicinal Chemistry, 页码:348-361 , 文章类型: Review,,卷期:2009年9-4]
- Potassium ion (K+) channels consist of a ubiquitous family of membrane proteins that play critical roles in a wide variety of physiological processes, such as the regulation of neuronal excitability, muscle contraction, ...
- Recent Advances in the Medicinal Chemistry of Sodium Channel Blockers and their Therapeutic Potential
[作者:Zuliani, V; Patel, MK; Fantini, M; Rivara, M,期刊:Current Topics in Medicinal Chemistry, 页码:396-415 , 文章类型: Review,,卷期:2009年9-4]
- The voltage-gated sodium channels (VGSCs) play a fundamental role in controlling cellular excitability. Abnormal activity of sodium channels is related to several pathological processes, including cardiac arrhythmias, ep...
- Researches Toward Potassium Channels on Tumor Progressions
[作者:Shen, Z; Yang, Q; You, QD,期刊:Current Topics in Medicinal Chemistry, 页码:322-329 , 文章类型: Review,,卷期:2009年9-4]
- As trans-membrane proteins located in cytoplasm and organelle membrane, potassium (K+) channels are generally divided into four super-families: voltage-gated K+ channels (K-v), Ca2+-activated K+ channels (K-Ca), inwardly...
- Drug Discoveries Towards Kv1.5 Potassium Channel
[作者:Yang, Q; Wang, XJ; Du, LP; Li, MY; You, QD,期刊:Current Topics in Medicinal Chemistry, 页码:339-347 , 文章类型: Review,,卷期:2009年9-4]
- Attributed to the extensive researches towards the functions of Kv1.5 gene (also known as KCN5A gene), the therapeutic significances of Kv1.5 channel have been paid special attentions to cardiovascular diseases as well a...
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