- Secretion of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with rapamycin
[作者:Moriya, H; Uchida, K; Okajima, T; Matsuda, T; Nadano, D,期刊:Archives of Biochemistry and Biophysics , 页码:87-92 , 文章类型: Article,,卷期:2011年508-1]
- The mammary epithelium produces numerous lipid droplets during lactation and secretes them in plasma membrane-enclosed vesicles known as milk fat globules. The biogenesis of such fat globules is considered to provide a m...
- Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages
[作者:Harada, N; Kanayama, M; Maruyama, A; Yoshida, A; Tazumi, K; Hosoya, T; Mimura, J; Toki, T; Maher, JM; Yamamoto, M; Itoh, K,期刊:Archives of Biochemistry and Biophysics , 页码:101-109 , 文章类型: Article,,卷期:2011年508-1]
- Iron is an essential element of hemoglobin, and efficient iron recycling from senescent erythrocytes by splenic macrophages is required for erythrocyte hemoglobin synthesis during erythropoiesis. Ferroportin 1 (Fpn1) is ...
- Bovine Serum Albumin protofibril-like aggregates formation: Solo but not simple mechanism
[作者:Vetri, V; D'Amico, M; Fodera, V; Leone, M; Ponzoni, A; Sberveglieri, G; Militello, V,期刊:Archives of Biochemistry and Biophysics , 页码:13-24 , 文章类型: Article,,卷期:2011年508-1]
- We report an experimental study on the model protein Bovine Serum Albumin (BSA), with the aim of elucidating the mechanisms by which a fully folded globular protein undergoes different aggregation pathways leading to the...
- Purification and characterization of cystathionine beta-synthase bearing a cobalt protoporphyrin
[作者:Majtan, T; Freeman, KM; Smith, AT; Burstyn, JN; Kraus, JP,期刊:Archives of Biochemistry and Biophysics , 页码:25-30 , 文章类型: Article,,卷期:2011年508-1]
- Human cystathionine beta-synthase (CBS), a pivotal enzyme in the metabolism of homocysteine, is a pyridoxal-5'-phosphate-dependent enzyme that also contains heme, a second cofactor whose function is still unclear. One st...
- Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3
[作者:Walters, J; Swartz, P; Mattos, C; Clark, AC,期刊:Archives of Biochemistry and Biophysics , 页码:31-38 , 文章类型: Article,,卷期:2011年508-1]
- Interactions between loops 2, 2' and 4, known as the loop bundle, stabilize the active site of caspase-3. Loop 4 (L4) is of particular interest due to its location between the active site and the dimer interface. We have...
- Contributions of cation-pi interactions to the collagen triple helix stability
[作者:Chen, CC; Hsu, W; Hwang, KC; Hwu, JR; Lin, CC; Horng, JC,期刊:Archives of Biochemistry and Biophysics , 页码:46-53 , 文章类型: Article,,卷期:2011年508-1]
- Cation-pi interactions are found to be an important noncovalent force in proteins. Collagen is a right-handed triple helix composed of three left-handed PPII helices, in which (X-Y-Gly) repeats dominate in the sequence. ...
- A new cytochrome P450 belonging to the 107L subfamily is responsible for the efficient hydroxylation of the drug terfenadine by Streptomyces platensis
[作者:Lombard, M; Salard, I; Sari, MA; Mansuy, D; Buisson, D,期刊:Archives of Biochemistry and Biophysics , 页码:54-63 , 文章类型: Article,,卷期:2011年508-1]
- Fexofenadine, an antihistamine drug used in allergic rhinitis treatment, can be produced by oxidative biotransformation of terfenadine by Streptomyces platensis, which involves three consecutive oxidation reactions. We r...
- Cloning and biochemical characterization of Staphylococcus aureus type IA DNA topoisomerase comprised of distinct five domains
[作者:Park, JE; Kim, HI; Park, JW; Park, JK; Lee, JS,期刊:Archives of Biochemistry and Biophysics , 页码:78-86 , 文章类型: Article,,卷期:2011年508-1]
- DNA topoisomerases play critical roles in regulating DNA topology and are essential enzymes for cell survival. In this study, a gene encoding type IA DNA topoisomerase was cloned from Staphylococcus aureus (S. aureus) sp...
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