- Mei-P26 regulates the maintenance of ovarian germline stem cells by promoting BMP signaling
[作者:Li, Y; Maines, JZ; Tastan, OY; McKearin, DM; Buszczak, M,期刊:Development, 页码:1547-1556 , 文章类型: Article,,卷期:2012年139-9]
- In the Drosophila ovary, bone morphogenetic protein (BMP) ligands maintain germline stem cells (GSCs) in an undifferentiated state. The activation of the BMP pathway within GSCs results in the transcriptional repression ...
- Different levels of Notch signaling regulate quiescence, renewal and differentiation in pancreatic endocrine progenitors
[作者:Ninov, N; Borius, M; Stainier, DYR,期刊:Development, 页码:1557-1567 , 文章类型: Article,,卷期:2012年139-9]
- Genetic studies have implicated Notch signaling in the maintenance of pancreatic progenitors. However, how Notch signaling regulates the quiescent, proliferative or differentiation behaviors of pancreatic progenitors at ...
- STUNTED mediates the control of cell proliferation by GA in Arabidopsis
[作者:Lee, LYC; Hou, XL; Fang, L; Fan, SG; Kumar, PP; Yu, H,期刊:Development, 页码:1568-1576 , 文章类型: Article,,卷期:2012年139-9]
- Gibberellins (GA) are an important family of plant growth regulators, which are essential for many aspects of plant growth and development. In the GA signaling pathway, the action of GA is opposed by a group of DELLA fam...
- Germ cell pluripotency, premature differentiation and susceptibility to testicular teratomas in mice
[作者:Heaney, JD; Anderson, EL; Michelson, MV; Zechel, JL; Conrad, PA; Page, DC; Nadeau, JH,期刊:Development, 页码:1577-1586 , 文章类型: Article,,卷期:2012年139-9]
- Testicular teratomas result from anomalies in germ cell development during embryogenesis. In the 129 family of inbred strains of mice, teratomas initiate around embryonic day (E) 13.5 during the same developmental period...
- SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development
[作者:Costa, G; Mazan, A; Gandillet, A; Pearson, S; Lacaud, G; Kouskoff, V,期刊:Development, 页码:1587-1598 , 文章类型: Article,,卷期:2012年139-9]
- At early stages of vertebrate ontogeny, blood and endothelial cells develop from a common mesodermal progenitor, the haemangioblast. Upon haematopoietic commitment, the haemangioblast generates blood precursors through p...
- Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis
[作者:Clark, BS; Cui, S; Miesfeld, JB; Klezovitch, O; Vasioukhin, V; Link, BA,期刊:Development, 页码:1599-1610 , 文章类型: Article,,卷期:2012年139-9]
- To gain insights into the cellular mechanisms of neurogenesis, we analyzed retinal neuroepithelia deficient for Llgl1, a protein implicated in apicobasal cell polarity, asymmetric cell division, cell shape and cell cycle...
- Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos
[作者:Itou, J; Kawakami, H; Quach, T; Osterwalder, M; Evans, SM; Zeller, R; Kawakami, Y,期刊:Development, 页码:1620-1629 , 文章类型: Article,,卷期:2012年139-9]
- How divergent genetic systems regulate a common pathway during the development of two serial structures, forelimbs and hindlimbs, is not well understood. Specifically, HAND2 has been shown to regulate Shh directly to ini...
- COUP-TFII controls amygdala patterning by regulating neuropilin expression
[作者:Tang, K; Rubenstein, JLR; Tsai, SY; Tsai, MJ,期刊:Development, 页码:1630-1639 , 文章类型: Article,,卷期:2012年139-9]
- The development of the progenitor zones in the pallium, lateral ganglionic eminence (LGE) and medial ganglionic eminence (MGE) in the subpallium has been well studied; however, so far the role of the caudal ganglionic em...
- A TGF beta-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development
[作者:Han, D; Zhao, H; Parada, C; Hacia, JG; Bringas, P; Chai, Y,期刊:Development, 页码:1640-1650 , 文章类型: Article,,卷期:2012年139-9]
- The tongue is a muscular organ and plays a crucial role in speech, deglutition and taste. Despite the important physiological functions of the tongue, little is known about the regulatory mechanisms of tongue muscle deve...
- Axial patterning interactions in the sea urchin embryo: suppression of nodal by Wnt1 signaling
[作者:Wei, Z; Range, R; Angerer, R; Angerer, L,期刊:Development, 页码:1662-1669 , 文章类型: Article,,卷期:2012年139-9]
- Wnt and Nodal signaling pathways are required for initial patterning of cell fates along anterior-posterior (AP) and dorsal-ventral (DV) axes, respectively, of sea urchin embryos during cleavage and early blastula stages...
- Analysis of centriole elimination during C. elegans oogenesis
[作者:Mikeladze-Dvali, T; von Tobel, L; Strnad, P; Knott, G; Leonhardt, H; Schermelleh, L; Gonczy, P,期刊:Development, 页码:1670-1679 , 文章类型: Article,,卷期:2012年139-9]
- Centrosomes are the principal microtubule organizing centers (MTOCs) of animal cells and comprise a pair of centrioles surrounded by pericentriolar material (PCM). Centriole number must be carefully regulated, notably to...
- Turning gene function ON and OFF using sense and antisense photo-morpholinos in zebrafish
[作者:Tallafuss, A; Gibson, D; Morcos, P; Li, YF; Seredick, S; Eisen, J; Washbourne, P,期刊:Development, 页码:1691-1699 , 文章类型: Article,,卷期:2012年139-9]
- To understand the molecular mechanisms of development it is essential to be able to turn genes on and off at will and in a spatially restricted fashion. Morpholino oligonucleotides (MOs) are very common tools used in sev...
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