- The identification of cutin synthase: formation of the plant polyester cutin
[作者：YEATS TREVOR H; MARTIN LAETITIA B B; VIART HELENE MF; ISAACSON TAL; HE YONGHUA; ZHAO LINGXIA; MATAS ANTONIO J; BUDA GREGORY J; DOMOZYCH DAVID S; CLAUSEN MADS H; ROSE JOCELYN K C,期刊：NATURE CHEMICAL BIOLOGY, 页码：609-611 , 文章类型： Article，,卷期：2012年8-7]
- A hydrophobic cuticle consisting of waxes and the polyester cutin covers the aerial epidermis of all land plants, providing essential protection from desiccation and other stresses. We have determined the enzymatic basis...
- Deciphering biased-agonism complexity reveals a new active AT(1) receptor entity
[作者：SAULIERE AUDE; BELLOT MORGANE; PARIS HERVE; DENIS COLETTE; FINANA FREDERIC; HANSEN JONAS T; ALTIE MARIEFRANCOISE; SEGUELAS MARIEHELENE; PATHAK ATUL; HANSEN JAKOB L; SENARD JEANMICHEL; GALES CELINE,期刊：NATURE CHEMICAL BIOLOGY, 页码：622-630 , 文章类型： Article，,卷期：2012年8-7]
- Functional selectivity of G protein-coupled receptor (GPCR) ligands toward different downstream signals has recently emerged as a general hallmark of this receptor class. However, pleiotropic and crosstalk signaling of G...
- A biased ligand for OXE-R uncouples G alpha and G beta gamma signaling within a heterotrimer
[作者：BLAETTERMANN STEFANIE; PETERS LUCAS; OTTERSBACH PHILIPP AARON; BOCK ANDREAS; KONYA VIKTORIA; WEAVER C DAVID; GONZALEZ ANGEL; SCHROEDER RALF; TYAGI RAHUL; LUSCHNIG PETRA; GAEB JUERGEN; HENNEN STEPHANIE; ULVEN TROND; PARDO LEONARDO; MOHR KLAUS; GUETSCHOW MICHAEL; HEINEMANN AKOS; KOSTENIS EVI,期刊：NATURE CHEMICAL BIOLOGY, 页码：631-638 , 文章类型： Article，,卷期：2012年8-7]
- Differential targeting of heterotrimeric G protein versus beta-arrestin signaling are emerging concepts in G protein-coupled receptor (GPCR) research and drug discovery, and biased engagement by GPCR ligands of either be...
- ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53
[作者：SULLIVAN KELLY D; PADILLAJUST NURIA; HENRY RYAN E; PORTER CHRISTOPHER C; KIM JIHYE; TENTLER JOHN J; ECKHARDT S GAIL; TAN AIK CHOON; DEGREGORI JAMES; ESPINOSA JOAQUIN M,期刊：NATURE CHEMICAL BIOLOGY, 页码：646-654 , 文章类型： Article，,卷期：2012年8-7]
- The p53 tumor suppressor orchestrates alternative stress responses including cell cycle arrest and apoptosis, but the mechanisms defining cell fate upon p53 activation are poorly understood. Several small-molecule activa...
- Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization
[作者：STANGER KAREN; STEFFEK MICAH; ZHOU LIJUAN; POZNIAK CHRISTINE D; QUAN CLIFFORD; FRANKE YVONNE; TOM JEFF; TAM CHRISTINE; ELLIOTT J MICHAEL; LEWCOCK JOSEPH W; ZHANG YINGNAN; MURRAY JEREMY; HANNOUSH RAMI N,期刊：NATURE CHEMICAL BIOLOGY, 页码：655-660 , 文章类型： Article，,卷期：2012年8-7]
- The caspases are a family of cytosolic proteases with essential roles in inflammation and apoptosis. Drug discovery efforts have focused on developing molecules directed against the active sites of caspases, but this app...
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