- The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia
[作者:Kang, R; Loux, T; Tang, DL; Schapiro, NE; Vernon, P; Livesey, KM; Krasinskas, A; Lotze, MT; Zeh, HJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7031-7036 , 文章类型: Article,,卷期:2012年109-18]
- Pancreatic cancer is an almost uniformly lethal disease, characterized by late diagnosis, early metastasis, resistance to chemotherapy, and early mutation of the Kras oncogene. Here we show that the receptor for advanced...
- The inexorable resistance of inertia determines the initial regime of drop coalescence
[作者:Paulsen, JD; Burton, JC; Nagel, SR; Appathurai, S; Harris, MT; Basaran, OA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6857-6861 , 文章类型: Article,,卷期:2012年109-18]
- Drop coalescence is central to diverse processes involving dispersions of drops in industrial, engineering, and scientific realms. During coalescence, two drops first touch and then merge as the liquid neck connecting th...
- Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail
[作者:Dvir, H; Shah, M; Girardi, E; Guo, LX; Farquhar, MG; Zajonc, DM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6916-6921 , 文章类型: Article,,卷期:2012年109-18]
- Hypercholesterolemia, high serum cholesterol in the form of LDL, is a major risk factor for atherosclerosis. LDL is mostly degraded in the liver after its cellular internalization with the LDL receptor (LDLR). This clath...
- The protein expression landscape of the Arabidopsis root
[作者:Petricka, JJ; Schauer, MA; Megraw, M; Breakfield, NW; Thompson, JW; Georgiev, S; Soderblom, EJ; Ohler, U; Moseley, MA; Grossniklaus, U; Benfey, PN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6811-6818 , 文章类型: Article,,卷期:2012年109-18]
- Because proteins are the major functional components of cells, knowledge of their cellular localization is crucial to gaining an understanding of the biology of multicellular organisms. We have generated a protein expres...
- General anesthesia alters time perception by phase shifting the circadian clock
[作者:Cheeseman, JF; Winnebeck, EC; Millar, CD; Kirkland, LS; Sleigh, J; Goodwin, M; Pawley, MDM; Bloch, G; Lehmann, K; Menzel, R; Warman, GR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7061-7066 , 文章类型: Article,,卷期:2012年109-18]
- Following general anesthesia, people are often confused about the time of day and experience sleep disruption and fatigue. It has been hypothesized that these symptoms may be caused by general anesthesia affecting the ci...
- Tissue deformation spatially modulates VEGF signaling and angiogenesis
[作者:Rivron, NC; Vrij, EJ; Rouwkema, J; Le Gac, S; van den Berg, A; Truckenmuller, RK; van Blitterswijk, CA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6886-6891 , 文章类型: Article,,卷期:2012年109-18]
- Physical forces play a major role in the organization of developing tissues. During vascular development, physical forces originating from a fluid phase or from cells pulling on their environment can alter cellular signa...
- beta-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas
[作者:Yang, CZ; Iyer, RR; Yu, ACH; Yong, RL; Park, DM; Weil, RJ; Ikejiri, B; Brady, RO; Lonser, RR; Zhuang, ZP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6963-6968 , 文章类型: Article,,卷期:2012年109-18]
- Astrocytes are the most abundant cell of the CNS and demonstrate contact inhibition in which a nonproliferative, nonmotile cellular state is achieved once stable intercellular contacts are formed between mature cells. Ce...
- Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling
[作者:Chang, L; Noseda, M; Higginson, M; Ly, M; Patenaude, A; Fuller, M; Kyle, AH; Minchinton, AI; Puri, MC; Dumont, DJ; Karsan, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6993-6998 , 文章类型: Article,,卷期:2012年109-18]
- Vascular smooth muscle cells (VSMC) have been suggested to arise from various developmental sources during embryogenesis, depending on the vascular bed. However, evidence also points to a common subpopulation of vascular...
|