- High-Density Lipoprotein Transport Through Aortic Endothelial Cells Involves Scavenger Receptor BI and ATP-Binding Cassette Transporter G1
[作者:Rohrer, L; Ohnsorg, PM; Lehner, M; Landolt, F; Rinninger, F; von Eckardstein, A,期刊:Circulation Research, 页码:1142-U38 , 文章类型: Article,,卷期:2009年104-10]
- Cholesterol efflux from macrophage foam cells is a rate-limiting step in reverse cholesterol transport. In this process cholesterol acceptors like high-density lipoproteins (HDL) and apolipoprotein (apo) A-I must cross t...
- Myc Regulates Embryonic Vascular Permeability and Remodeling
[作者:Kokai, E; Voss, F; Fleischer, F; Kempe, S; Marinkovic, D; Wolburg, H; Leithauser, F; Schmidt, V; Deutsch, U; Wirth, T,期刊:Circulation Research, 页码:1151-U59 , 文章类型: Article,,卷期:2009年104-10]
- Previous work has shown that c-Myc is required for adequate vasculogenesis and angiogenesis. To further investigate the contribution of Myc to these processes, we conditionally expressed c-Myc in embryonic endothelial ce...
- Human Paraoxonase Gene Cluster Transgenic Overexpression Represses Atherogenesis and Promotes Atherosclerotic Plaque Stability in ApoE-Null Mice
[作者:She, ZG; Zheng, W; Wei, YS; Chen, HZ; Wang, AB; Li, HL; Liu, G; Zhang, R; Liu, JJ; Stallcup, WB; Zhou, ZJ; Liu, DP; Liang, CC,期刊:Circulation Research, 页码:1160-U87 , 文章类型: Article,,卷期:2009年104-10]
The paraoxonase (PON) gene cluster consists of the PON1, PON2, and PON3 genes, each of which can individually inhibit atherogenesis. To analyze the functions of the PON gene cluster (PC) in atherogenesis and plaque st...
- Phosphodiesterase 2 Mediates Redox-Sensitive Endothelial Cell Proliferation and Angiogenesis by Thrombin via Rac1 and NADPH Oxidase 2
[作者:Diebold, I; Djordjevic, T; Petry, A; Hatzelmann, A; Tenor, H; Hess, J; Gorlach, A,期刊:Circulation Research, 页码:1169-U111 , 文章类型: Article,,卷期:2009年104-10]
- Cyclic nucleotide phosphodiesterases (PDEs) control the levels of the second messengers cAMP and cGMP in many cell types including endothelial cells. Although PDE2 has the unique property to be activated by cGMP but to h...
- Regulation of Oxygen Distribution in Tissues by Endothelial Nitric Oxide
[作者:Victor, VM; Nunez, C; D'Ocon, P; Taylor, CT; Esplugues, JV; Moncada, S,期刊:Circulation Research, 页码:1178-U121 , 文章类型: Article,,卷期:2009年104-10]
- Nitric oxide (NO) decreases cellular oxygen (O-2) consumption by competitively inhibiting cytochrome c oxidase. Here, we show that endogenously released endothelial NO, either basal or stimulated, can modulate O-2 consum...
- Interleukin-6 Modulates the Expression of the Bone Morphogenic Protein Receptor Type II Through a Novel STAT3-microRNA Cluster 17/92 Pathway
[作者:Brock, M; Trenkmann, M; Gay, RE; Michel, BA; Gay, S; Fischler, M; Ulrich, S; Speich, R; Huber, LC,期刊:Circulation Research, 页码:1184-U139 , 文章类型: Article,,卷期:2009年104-10]
- Dysregulated expression of bone morphogenetic protein receptor type II (BMPR2) is a pathogenetic hallmark of pulmonary hypertension. Downregulation of BMPR2 protein but not mRNA has been observed in multiple animal model...
- 3-Deazaadenosine Prevents Smooth Muscle Cell Proliferation and Neointima Formation by Interfering With Ras Signaling
[作者:Sedding, DG; Trobs, M; Reich, F; Walker, G; Fink, L; Haberbosch, W; Rau, W; Tillmanns, H; Preissner, KT; Bohle, RM; Langheinrich, AC,期刊:Circulation Research, 页码:1192-U161 , 文章类型: Article,,卷期:2009年104-10]
- 3-Deazaadenosine (c3Ado) is a potent inhibitor of S-adenosylhomocysteine hydrolase, which regulates cellular methyltransferase activity. In the present study, we sought to determine the effect of c3Ado on vascular smooth...
- Transient Expression of FRNK Reveals Stage-Specific Requirement for Focal Adhesion Kinase Activity in Cardiac Growth
[作者:DiMichele, LA; Hakim, ZS; Sayers, RL; Rojas, M; Schwartz, RJ; Mack, CP; Taylor, JM,期刊:Circulation Research, 页码:1201-U196 , 文章类型: Article,,卷期:2009年104-10]
- Focal adhesion kinase (FAK) is strongly activated by integrins and growth factors and is essential for embryonic development. We previously showed that the C terminus of FAK is expressed as a separate protein termed FAK-...
- Hypoxic Preconditioning Enhances the Benefit of Cardiac Progenitor Cell Therapy for Treatment of Myocardial Infarction by Inducing CXCR4 Expression
[作者:Tang, YL; Zhu, WQ; Cheng, M; Chen, LJ; Zhang, J; Sun, T; Kishore, R; Phillips, MI; Losordo, DW; Qin, GJ,期刊:Circulation Research, 页码:1209-U218 , 文章类型: Article,,卷期:2009年104-10]
- Myocardial infarction rapidly depletes the endogenous cardiac progenitor cell pool, and the inefficient recruitment of exogenously administered progenitor cells limits the effectiveness of cardiac cell therapy. Recent re...
- Reduced Vessel Elasticity Alters Cardiovascular Structure and Function in Newborn Mice
[作者:Wagenseil, JE; Ciliberto, CH; Knutsen, RH; Levy, MA; Kovacs, A; Mecham, RP,期刊:Circulation Research, 页码:1217-U233 , 文章类型: Article,,卷期:2009年104-10]
- Elastic blood vessels provide capacitance and pulse-wave dampening, which are critically important in a pulsatile circulatory system. By studying newborn mice with reduced (Eln(+/-)) or no (Eln(-/-)) elastin, we determin...
- Multipotent Progenitor Cells Are Present in Human Peripheral Blood
[作者:Cesselli, D; Beltrami, AP; Rigo, S; Bergamin, N; D'Aurizio, F; Verardo, R; Piazza, S; Klaric, E; Fanin, R; Toffoletto, B; Marzinotto, S; Mariuzzi, L; Finato, N; Pandolfi, M; Leri, A; Schneider, C; Beltrami, CA; Anversa, P,期刊:Circulation Research, 页码:1225-U271 , 文章类型: Article,,卷期:2009年104-10]
- To determine whether the peripheral blood in humans contains a population of multipotent progenitor cells (MPCs), products of leukapheresis were obtained from healthy donor volunteers following the administration of gran...
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