- Receptor targeted polymers, dendrimers, liposomes: Which nanocarrier is the most efficient for tumor-specific treatment and imaging?
[作者:Saad, M; Garbuzenko, OB; Ber, E; Chandna, P; Khandare, JJ; Pozharov, VP; Minko, T,期刊:Journal of controlled release, 页码:107-114 , 文章类型: Article,,卷期:2008年130-2]
- To compare the influence of different characteristics of nanocarriers on the efficacy of chemotherapy and imaging, we designed, characterized, and evaluated three widely used nanocarriers: linear polymer, dendrimer and l...
- Multi-functional nanocarriers for targeted delivery of drugs and genes
[作者:Jabr-Milane, L; van Vlerken, L; Devalapally, H; Shenoy, D; Komareddy, S; Bhavsar, M; Amiji, M,期刊:Journal of controlled release, 页码:121-128 , 文章类型: Article,,卷期:2008年130-2]
- In this review article, we describe the different nano-platforms developed in our laboratory at Northeastern University in Boston, MA for the targeted delivery of drugs and genes. Special emphasis is placed on nano-platf...
- A peptide-based carrier for intracellular delivery of proteins into malignant glial cells in vitro
[作者:Wu, CX; Lo, SL; Boulaire, J; Hong, MLW; Beh, HM; Leung, DSY; Wang, S,期刊:Journal of controlled release, 页码:140-145 , 文章类型: Article,,卷期:2008年130-2]
- Aiming at identification of novel peptides that can be employed for effective targeting of malignant gliomas, we used a 12-mer peptide phage display library and cultured human malignant glioma cells for phage selection. ...
- Lipid nanocapsules loaded with an organometallic tamoxifen derivative as a novel drug-carrier system for experimental malignant gliomas
[作者:Allard, E; Passirani, C; Garcion, E; Pigeon, P; Vessieres, A; Jaouen, G; Benoit, JP,期刊:Journal of controlled release, 页码:146-153 , 文章类型: Article,,卷期:2008年130-2]
- Ferrocenyl diphenol tamoxifen derivative (Fc-diOH) is one of the most active molecules of a new class of organometallic drugs, showing in vitro antiproliferative effects on both hormone-dependent and independent breast c...
- Modified pectin-based carrier for gene delivery: Cellular barriers in gene delivery course
[作者:Katav, T; Liu, L; Traitel, T; Goldbart, R; Wolfson, M; Kost, J,期刊:Journal of controlled release, 页码:183-191 , 文章类型: Article,,卷期:2008年130-2]
- The use of polysaccharides as DNA carriers has high potential for gene therapy applications. Pectin is a structural plant polysaccharide heterogeneous with respect to its chemical structure. It contains branches rich in ...
- Surface coating of PLGA microparticles with protamine enhances their immunological performance through facilitated phagocytosis
[作者:Gomez, JMM; Csaba, N; Fischer, S; Sichelstiel, A; Kundig, TM; Gander, B; Johansen, P,期刊:Journal of controlled release, 页码:161-167 , 文章类型: Article,,卷期:2008年130-2]
- Surface modifications of poly(lactide-co-glycolide) microparticles with different polycationic electrolytes have mainly been studied for conjugation to antigens and/or adjuvants. However, the in vivo immunological effect...
- Depot formulation of vasoactive intestinal peptide by protamine-based biodegradable nanoparticles
[作者:Wernig, K; Griesbacher, M; Andreae, F; Hajos, F; Wagner, J; Mosgoeller, W; Zimmer, A,期刊:Journal of controlled release, 页码:192-198 , 文章类型: Article,,卷期:2008年130-2]
- Drug delivery of protein and peptide-based drugs, which represent a growing and important therapeutic class, is hampered by these drugs' very short half-lives. High susceptibility towards enzymatic degradation necessitat...
- Cytokine adsorption/release on uniform magnetic nanoparticles for localized drug delivery
[作者:Mejias, R; Costo, R; Roca, AG; Arias, CF; Veintemillas-Verdaguer, S; Gonzalez-Carreno, T; Morales, MD; Serna, CJ; Manes, S; Barber, DF,期刊:Journal of controlled release, 页码:168-174 , 文章类型: Article,,卷期:2008年130-2]
- Attachment of cytokines to magnetic nanoparticles has been developed as a system for controlled local drug release in cancer therapy. We studied the ad sorption/release of murine interferon gamma (IFN-gamma) on negativel...
- Dynamics of photoinduced endosomal release of polyplexes
[作者:de Bruin, KG; Fella, C; Ogris, M; Wagner, E; Ruthardt, N; Brauchle, C,期刊:Journal of controlled release, 页码:175-182 , 文章类型: Article,,卷期:2008年130-2]
- Endosomal escape is a well-known bottleneck for successful delivery of macromolecular drugs and genes. Photochemical disruption of endosomal membranes is an approach to overcome this bottleneck. In this study, we used th...
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