- Delivery of siRNA mediated by histidine-containing reducible polycations
[作者:Stevenson, M; Ramos-Perez, V; Singh, S; Soliman, M; Preece, JA; Briggs, SS; Read, ML; Seymour, LW,期刊:Journal of controlled release, 页码:46-56 , 文章类型: Article,,卷期:2008年130-1]
- Histidine containing reducible polycations based on CH6K3H6C monomers (His6 RPCs), are highly effective DNA transfection agents combining pH buffering endosomal escape mechanisms with rapid unpackaging following reductio...
- Mechanistic investigation of poly(ethylene imine)-based siRNA delivery: Disulfide bonds boost intracellular release of the cargo
[作者:Breunig, M; Hozsa, C; Lungwitz, U; Watanabe, K; Umeda, I; Kato, H; Goepferich, A,期刊:Journal of controlled release, 页码:57-63 , 文章类型: Article,,卷期:2008年130-1]
- Poly(ethylene imine) (PEI) has gained increasing attention in the delivery of small interfering RNAs (siRNAs) into cells. In order to further optimize PEI for this application, the first goal of this study was to examine...
- Development of a vessel-simulating flow-through cell method for the in vitro evaluation of release and distribution from drug-eluting stents
[作者:Neubert, A; Sternberg, K; Nagel, S; Harder, C; Schmitz, KP; Kroemer, HK; Weitschies, W,期刊:Journal of controlled release, 页码:2-8 , 文章类型: Article,,卷期:2008年130-1]
- A novel in vitro dissolution test for drug-eluting stents (DES) based on the compendial flow-through cell was developed. The model contains an additional compartment simulating the vessel wall enabling the examination of...
- Novel poly(ethylene imine) biscarbamate conjugate as an efficient and nontoxic gene delivery system
[作者:Xu, SL; Chen, MY; Yao, Y; Zhang, ZQ; Jin, T; Huang, Y; Zhu, H,期刊:Journal of controlled release, 页码:64-68 , 文章类型: Article,,卷期:2008年130-1]
- We report a novel poly(ethylene imine) biscarbamate conjugate (PEIC) with a low molecular weight (M-W = 2800, M = 910), and low cytotoxicity which has orders of magnitude higher luciferase gene transfection activity at i...
- Controlled delivery of anti-sense oligodeoxynucleotide from multilayered biocompatible phosphorylcholine polymer films
[作者:Zhang, ZQ; Cao, XC; Zhao, XB; Holt, CM; Lewis, AL; Lu, JR,期刊:Journal of controlled release, 页码:69-76 , 文章类型: Article,,卷期:2008年130-1]
- Fabrication of polymeric multilayered films based on the electrostatic self-assembly of polycations and polyanions is a promising approach for controlled loading and release in gene delivery. In this study, we have fabri...
- Gene delivery to dendritic cells mediated by complexes of lipoplexes and pH-sensitive fusogenic polymer-modified liposomes
[作者:Yuba, E; Kojima, C; Sakaguchi, N; Harada, A; Koiwai, K; Kono, K,期刊:Journal of controlled release, 页码:77-83 , 文章类型: Article,,卷期:2008年130-1]
- Dendritic cells (DCs) are potent professional antigen presenting cells that are useful for cancer immunotherapy. We previously reported the preparation and characterization of complexes of lipoplexes with pH-sensitive fu...
- Non-invasive screening method for simultaneous evaluation of in vivo growth factor release profiles from multiple ectopic bone tissue engineering implants
[作者:Kempen, DHR; Lu, L; Classic, KL; Hefferan, TE; Creemers, LB; Maran, A; Dhert, WJA; Yaszemski, MJ,期刊:Journal of controlled release, 页码:15-21 , 文章类型: Article,,卷期:2008年130-1]
- The purpose of this study was to develop and validate a screening method based on scintillation probes for the simultaneous evaluation of in vivo growth factor release profiles of multiple implants in the same animal. Fi...
- Subcellular compartment targeting of layered double hydroxide nanoparticles
[作者:Xu, ZP; Niebert, M; Porazik, K; Walker, TL; Cooper, HM; Middelberg, APJ; Gray, PP; Bartlett, PF; Lu, GQ,期刊:Journal of controlled release, 页码:86-94 , 文章类型: Article,,卷期:2008年130-1]
- Current investigations show that layered double hydroxide (LDH) nanoparticles have high potential as effective non-viral agents for cellular drug delivery due to their low cytotoxicity. good biocompatibility, high drug l...
- In vitro-in vivo correlation for wet-milled tablet of poorly water-soluble cilostazol
[作者:Jinno, J; Kamada, N; Miyake, M; Yamada, K; Mukai, T; Odomi, M; Toguchi, H; Liversidge, GG; Higaki, K; Kimura, T,期刊:Journal of controlled release, 页码:29-37 , 文章类型: Article,,卷期:2008年130-1]
- The purpose of the present study was to investigate oral bioavailability of an immediate release tablet containing wet-milled crystals of a poorly water-soluble drug, cilostazol, and to establish in vitro-in vivo correla...
- Novel poly(amido amine)s with bioreducible disulfide linkages in their diamino-units: Structure effects and in vitro gene transfer properties
[作者:Piest, M; Lin, C; Mateos-Timoneda, MA; Lok, MC; Hennink, WE; Feijen, J; Engbersen, JFJ,期刊:Journal of controlled release, 页码:38-45 , 文章类型: Article,,卷期:2008年130-1]
- A series of novel water-soluble, bioreducible poly(amido amine)s containing disulfide linkages in their amino units (SS-PAAs) was synthesized by Michael addition polymerization of NN'-dimethylcystamine (DMC) with various...
|