- Use of the BioDis to generate a physiologically relevant IVIVC
[作者:Klein, S; Rudolph, MW; Skalsky, B; Petereit, HU; Dressman, JB,期刊:Journal of controlled release, 页码:216-219 , 文章类型: Article,,卷期:2008年130-3]
- In the last decades there has been continual interest in site-specific delivery to the colon. Recently, new types of site-specific delivery formulations have been developed for the treatment of ulcerative colitis and oth...
- Esterase-catalyzed dePEGylation of pH-sensitive vesicles modified with cleavable PEG-lipid derivatives
[作者:Xu, H; Deng, YH; Chen, DW; Hong, WW; Lu, Y; Dong, XH,期刊:Journal of controlled release, 页码:238-245 , 文章类型: Article,,卷期:2008年130-3]
- To make vesicles for the better controlled content release, we modified cholesteryl hemisuccinate (CHEMS)-derived vesicles with PEG-lipid derivatives. Two cholesterol analogs, cholesteryl hemisuccinate (CHEMS) and choles...
- PTD-modified ATTEMPTS system for enhanced asparaginase therapy: A proof-of-concept investigation
[作者:Kwon, YM; Li, YT; Liang, JF; Park, YJ; Chang, LC; Yang, VC,期刊:Journal of controlled release, 页码:252-258 , 文章类型: Article,,卷期:2008年130-3]
- Macromolecular drugs such as proteins and gene products are presumably the most desirable therapeutic agents due to their unmatched substrate specificity and reaction efficiency. Yet, clinical use of these drugs has met ...
- Formulating erythropoietin-loaded sustained-release PLGA microspheres without protein aggregation
[作者:Geng, Y; Yuan, W; Wu, F; Chen, J; He, M; Jin, T,期刊:Journal of controlled release, 页码:259-265 , 文章类型: Article,,卷期:2008年130-3]
- We report a simple method to microencapsulate erythropoietin (EPO, a protein easily denatured and antigenized by contact with water-organic solvent interfaces) into poly(lactic-co-glycolic acid) (PLGA) microspheres with ...
- Triggered release of siRNA from poly(ethylene glycol)-protected, pH-dependent liposomes
[作者:Auguste, DT; Furman, K; Wong, A; Fuller, J; Armes, SR; Deming, TJ; Langer, R,期刊:Journal of controlled release, 页码:266-274 , 文章类型: Article,,卷期:2008年130-3]
- The ability of small interfering RNA (siRNA) to regulate gene expression has potential therapeutic applications, but its use is limited by inefficient delivery. Triggered release of adsorbed poly(ethylene glycol) (PEG)-b...
- Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair
[作者:Hardwicke, J; Ferguson, EL; Moseley, R; Stephens, P; Thomas, DW; Duncan, R,期刊:Journal of controlled release, 页码:275-283 , 文章类型: Article,,卷期:2008年130-3]
- Growth factors are known to act in concert to promote wound repair, but their topical application rarely leads to a significant clinical improvement of chronic wounds due to premature inactivation in wound environment. T...
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