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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共8条记录   A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways [作者：Mamidipudi, V; Cartwright, CA,期刊：Oncogene, 页码：4421-4433 , 文章类型： Article，,卷期：2009年28-50] Earlier we showed that RACK1 regulates growth of human colon cells by suppressing Src activity at G(1) and mitotic checkpoints. Here, we show that RACK1 also induces apoptosis of the cells, partly by inhibiting Src. In t... The GAB2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancer [作者：Mira, A; Isella, C; Renzulli, T; Cantarella, D; Martelli, ML; Medico, E,期刊：Oncogene, 页码：4444-4455 , 文章类型： Article，,卷期：2009年28-50] Acquisition of independence from anchorage to the extracellular matrix is a critical event for onset and progression of solid cancers. To identify and characterize new genes conferring anchorage independence, we transduc... YKL-40, a secreted glycoprotein, promotes tumor angiogenesis [作者：Shao, R; Hamel, K; Petersen, L; Cao, QJ; Arenas, RB; Bigelow, C; Bentley, B; Yan, W,期刊：Oncogene, 页码：4456-4468 , 文章类型： Article，,卷期：2009年28-50] Tumor angiogenesis is of paramount importance in solid tumor development. Elevated serum levels of YKL-40, which is a secreted heparin-binding glycoprotein, have been associated with a worse prognosis from various advanc... Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation [作者：Aylon, Y; Yabuta, N; Besserglick, H; Buganim, Y; Rotter, V; Nojima, H; Oren, M,期刊：Oncogene, 页码：4469-4479 , 文章类型： Article，,卷期：2009年28-50] The Lats2 tumor suppressor protein has been implicated earlier in promoting p53 activation in response to mitotic apparatus stress, by preventing Mdm2-driven p53 degradation. We now report that Lats2 also has a role in a... The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts [作者：Shaw, A; Gipp, J; Bushman, W,期刊：Oncogene, 页码：4480-4490 , 文章类型： Article，,卷期：2009年28-50] The Hedgehog (Hh) pathway contributes to prostate cancer growth and progression. The presence of robust Sonic Hedgehog (Shh) expression in both normal prostate and localized cancer challenged us to explain the unique gro... Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer [作者：Liu, G; Bollig-Fischer, A; Kreike, B; van de Vijver, MJ; Abrams, J; Ethier, SP; Yang, ZQ,期刊：Oncogene, 页码：4491-4500 , 文章类型： Article，,卷期：2009年28-50] Earlier, mapping of the 9p23-24 amplicon in esophageal cancer cell lines led us to the positional cloning of gene amplified in squamous cell carcinoma 1 (GASC1), which encodes a nuclear protein with a Jumonji C domain th... Loss-of-function genetic screens as a tool to improve the diagnosis and treatment of cancer [作者：Mullenders, J; Bernards, R,期刊：Oncogene, 页码：4409-4420 , 文章类型： Review，,卷期：2009年28-50] A major impediment to the effective treatment of cancer is the molecular heterogeneity of the disease, which is also reflected in an equally diverse pattern of clinical responses to therapy. Currently, only few drugs are... RB has a critical role in mediating the in vivo checkpoint response, mitigating secondary DNA damage and suppressing liver tumorigenesis initiated by aflatoxin B1 [作者：Reed, CA; Mayhew, CN; McClendon, AK; Yang, X; Witkiewicz, A; Knudsen, ES,期刊：Oncogene, 页码：4434-4443 , 文章类型： Article，,卷期：2009年28-50] Hepatocellular carcinoma (HCC) is a significant worldwide health concern that is associated with discrete etiological events, encompassing viral infection, metabolic stress and genotoxic compounds. In particular, exposur...