- Lysine 269 is essential for cyclin D1 ubiquitylation by the SCFFbx4/alpha B-crystallin ligase and subsequent proteasome-dependent degradation
[作者：Barbash, O; Egan, E; Pontano, LL; Kosak, J; Diehl, JA,期刊：Oncogene, 页码：4317-4325 , 文章类型： Article，,卷期：2009年28-49]
- Protein ubiquitylation is a complex enzymatic process that results in the covalent attachment of ubiquitin, through Gly-76 of ubiquitin, to an epsilon NH2 group of an internal lysine residue in a given substrate. Althoug...
- Genetic inactivation of ApoJ/clusterin: effects on prostate tumourigenesis and metastatic spread
[作者：Bettuzzi, S; Davalli, P; Davoli, S; Chayka, O; Rizzi, F; Belloni, L; Pellacani, D; Fregni, G; Astancolle, S; Fassan, M; Corti, A; Baffa, R; Sala, A,期刊：Oncogene, 页码：4344-4352 , 文章类型： Article，,卷期：2009年28-49]
- ApoJ/Clusterin (CLU) is a heterodimeric protein localized in the nucleus, cytoplasm or secretory organelles and involved in cell survival and neoplastic transformation. Its function in human cancer is still highly contro...
- Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells
[作者：Shimabe, M; Goyama, S; Watanabe-Okochi, N; Yoshimi, A; Ichikawa, M; Imai, Y; Kurokawa, M,期刊：Oncogene, 页码：4364-4374 , 文章类型： Article，,卷期：2009年28-49]
- Ecotropic viral integration site-1 (Evi-1) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). Aberrant expression of Evi-1 has been frequently foun...
- Heat shock protein 27 mediates repression of androgen receptor function by protein kinase D1 in prostate cancer cells
[作者：Hassan, S; Biswas, MHU; Zhang, C; Du, C; Balaji, KC,期刊：Oncogene, 页码：4386-4396 , 文章类型： Article，,卷期：2009年28-49]
- We have previously shown that protein kinase D1 (PKD1), charter member of PKD protein family, is downregulated in advanced prostate cancer ( PC) and influences androgen receptor (AR) function in PC cells. Other independe...
- Transcription activity is required for p53-dependent tumor suppression
[作者：Gaidarenko, O; Xu, Y,期刊：Oncogene, 页码：4397-4401 , 文章类型： Article，,卷期：2009年28-49]
- As a transcription factor, the critical tumor suppressor, p53, directly regulates the transcription of hundreds of genes, leading to cell-cycle arrest, apoptosis, cellular senescence and differentiation. Although it has ...
- Pannexin2 as a novel growth regulator in C6 glioma cells
[作者：Lai, CPK; Bechberger, JF; Naus, CC,期刊：Oncogene, 页码：4402-4408 , 文章类型： Article，,卷期：2009年28-49]
- Connexins (Cxs), the gap junction proteins, have been found to be downregulated in many types of cancers including gliomas. By restoring gap junctional communication in cancer cell models, the neoplastic phenotype can be...
- Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage
[作者：Provenzano, PP; Inman, DR; Eliceiri, KW; Keely, PJ,期刊：Oncogene, 页码：4326-4343 , 文章类型： Article，,卷期：2009年28-49]
- Mammographically dense breast tissue is one of the greatest risk factors for developing breast carcinoma, yet the associated molecular mechanisms remain largely unknown. Importantly, regions of high breast density are as...
- TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer
[作者：Szajnik, M; Szczepanski, MJ; Czystowska, M; Elishaev, E; Mandapathil, M; Nowak-Markwitz, E; Spaczynski, M; Whiteside, TL,期刊：Oncogene, 页码：4353-4363 , 文章类型： Article，,卷期：2009年28-49]
- Toll-like receptors (TLRs) expressed on immune cells trigger inflammatory responses. TLRs are also expressed on ovarian cancer (OvCa) cells, but the consequences of signaling by the TLR4/MyD88 pathway in these cells are ...
- SNAI1 expression in colon cancer related with CDH1 and VDR downregulation in normal adjacent tissue
[作者：Pena, C; Garcia, JM; Larriba, MJ; Barderas, R; Gomez, I; Herrera, M; Garcia, V; Silva, J; Dominguez, G; Rodriguez, R; Cuevas, J; de Herreros, AG; Casal, JI; Munoz, A; Bonilla, F,期刊：Oncogene, 页码：4375-4385 , 文章类型： Article，,卷期：2009年28-49]
- SNAI1, ZEB1, E-cadherin (CDH1), and vitamin D receptor (VDR) genes regulate the epithelial-mesenchymal transition (EMT) that initiates the invasion process of many tumor cells. We hypothesized that this process could als...
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