- Telomerase deficiency and telomere dysfunction inhibit mammary tumors induced by polyomavirus middle T oncogene
[作者:Jaskelioff, M; Song, W; Xia, J; Liu, C; Kramer, J; Koido, S; Gendler, SJ; Calderwood, SK; Gong, J,期刊:Oncogene, 页码:4225-4236 , 文章类型: Article,,卷期:2009年28-48]
- Mice transgenic for MUC1 (mucin 1) and polyomavirus middle T (PyMT) develop mammary carcinomas within 15 weeks with 100% penetrance. PyMT-induced mammary tumorigenesis is closely correlated with robust telomerase express...
- PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis
[作者:Gu, JJ; Wang, Z; Reeves, R; Magnuson, NS,期刊:Oncogene, 页码:4261-4271 , 文章类型: Article,,卷期:2009年28-48]
- The serine/threonine kinase, PIM1, is involved in promoting cell survival in part by phosphorylation and inhibition of proapoptotic proteins. Apoptosis signaling kinase 1 (ASK1), a mitogen-activated protein kinase kinase...
- Regulation of miRNA expression by Src and contact normalization: effects on nonanchored cell growth and migration
[作者:Li, X; Shen, Y; Ichikawa, H; Antes, T; Goldberg, GS,期刊:Oncogene, 页码:4272-4283 , 文章类型: Article,,卷期:2009年28-48]
- Transformation by the Src tyrosine kinase (Src) promotes nonanchored cell growth and migration. However, non-transformed cells can force Src-transformed cells to assume a normal morphology and phenotype by a process call...
- Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions
[作者:Walerych, D; Olszewski, MB; Gutkowska, M; Helwak, A; Zylicz, M; Zylicz, A,期刊:Oncogene, 页码:4284-4294 , 文章类型: Article,,卷期:2009年28-48]
- p53 as an unstable protein in vitro likely requires stabilizing factors to act as a tumor suppressor in vivo. Here, we show that in human cells transfected with wildtype (WT) p53, Hsp90 and Hsp70 molecular chaperones mai...
- Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner
[作者:di Martino, E; L'Hote, CG; Kennedy, W; Tomlinson, DC; Knowles, MA,期刊:Oncogene, 页码:4306-4316 , 文章类型: Article,,卷期:2009年28-48]
- Although activating mutations of fibroblast growth factor receptor 3 (FGFR3) are frequent in bladder tumors, little information is available on their specific effects in urothelial cells or the basis for the observed mut...
- Synergistic proapoptotic effects of the two tyrosine kinase inhibitors pazopanib and lapatinib on multiple carcinoma cell lines
[作者:Olaussen, KA; Commo, F; Tailler, M; Lacroix, L; Vitale, I; Raza, SQ; Richon, C; Dessen, P; Lazar, V; Soria, JC; Kroemer, G,期刊:Oncogene, 页码:4249-4260 , 文章类型: Article,,卷期:2009年28-48]
- Pazopanib and lapatinib are two tyrosine kinase inhibitors that have been designed to inhibit the VEGF tyrosine kinase receptors 1, 2 and 3 (pazopanib), and the HER1 and HER2 receptors in a dual manner (lapatinib). Pazop...
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