- Dissecting the Structure, Thermodynamic Stability, and Aggregation Properties of the A25T Transthyretin (A25T-TTR) Variant Involved in Leptomeningeal Amyloidosis: Identifying Protein Partners That Co-Aggregate during A25T-TTR Fibrillogenesis in Cerebrospinal Fluid
[作者:Azevedo, EPC; Pereira, HM; Garratt, RC; Kelly, JW; Foguel, D; Palhano, FL,期刊:Biochemistry, 页码:11070-11083 , 文章类型: Article,,卷期:2011年50-51]
- Deposition of amorphous aggregates and fibrils of transthyretin (TTR) in leptomeninges and subarachnoid vessels is a characteristic of leptomeningeal amyloidosis (LA), a currently untreatable cerebral angiopathy. Herein,...
- Structure and Dynamics of Mycobacterium tuberculosis Truncated Hemoglobin N: Insights from NMR Spectroscopy and Molecular Dynamics Simulations
[作者:Savard, PY; Daigle, R; Morin, S; Sebilo, A; Meindre, F; Lague, P; Guertin, M; Gagne, SM,期刊:Biochemistry, 页码:11121-11130 , 文章类型: Article,,卷期:2011年50-51]
- The potent nitric oxide dioxygenase (NOD) activity (trHbN-Fe(2+)-O(2) + (center dot)NO -> trHbN-Fe(3+)-OH(2) + NO(3)(-)) of Mycobacterium tuberculosis truncated hemoglobin N (trHbN) protects aerobic respiration from inhi...
- Tryptophan 697 Modulates Hydride and Interflavin Electron Transfer in Human Methionine Synthase Reductase
[作者:Meints, CE; Gustafsson, FS; Scrutton, NS; Woltherst, KR,期刊:Biochemistry, 页码:11131-11142 , 文章类型: Article,,卷期:2011年50-51]
- Human methionine synthase reductase (MSR), a diflavin oxidoreductase, plays a vital role in methionine and folate metabolism by sustaining methionine synthase (MS) activity. MSR catalyzes the oxidation of NADPH and shutt...
- Phosphatidylinositol 3,4,5-Trisphosphate Activity Probes for the Labeling and Proteomic Characterization of Protein Binding Partners
[作者:Rowland, MM; Bostic, HE; Gong, DH; Speers, AE; Lucas, N; Cho, WH; Cravatt, BF; Best, MD,期刊:Biochemistry, 页码:11143-11161 , 文章类型: Article,,卷期:2011年50-51]
- Phosphatidylinositol polyphosphate lipids, such as phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P(3)], regulate critical biological processes, many of which are aberrant in disease. These lipids often act as site-s...
- On the Collective Nature of Phytochrome Photoactivation
[作者:Song, C; Psakis, G; Lang, C; Mailliet, J; Zaanen, J; Gartner, W; Hughes, J; Matysik, J,期刊:Biochemistry, 页码:10987-10989 , 文章类型: Article,,卷期:2011年50-51]
- The red/far-red-sensing biological photoreceptor phytochrome is a paradigmatic two-state signaling system. The two thermally stable states are interconverted via a photoreaction of the covalently bound tetrapyrrole chrom...
- The Structure, Dynamics, and Binding of the LA45 Module Pair of the Low-Density Lipoprotein Receptor Suggest an Important Role for LA4 in Ligand Release
[作者:Guttman, M; Komives, EA,期刊:Biochemistry, 页码:11001-11008 , 文章类型: Article,,卷期:2011年50-51]
- The low-density lipoprotein receptor (LDLR), the primary receptor for cholesterol uptake, binds ligands through its seven LDL-A modules (LAs). We present nuclear magnetic resonance (NMR) and ligand binding measurements o...
- Sugar Recognition by CscB and LacY
[作者:Sugihara, J; Smirnova, I; Kasho, V; Kaback, HR,期刊:Biochemistry, 页码:11009-11014 , 文章类型: Article,,卷期:2011年50-51]
- The sucrose permease (CscB) and lactose permease (LacY) of Escherichia colt belong to the oligosaccharide/H(+) symporter subfamily of the major facilitator superfamily, and both catalyze sugar/H(+) symport across the cyt...
- Lipid-Mediated Unfolding of 3 beta-Hydroxysteroid Dehydrogenase 2 Is Essential for Steroidogenic Activity
[作者:Rajapaksha, M; Thomas, JL; Streeter, M; Prasad, M; Whittal, RM; Bell, JD; Bose, HS,期刊:Biochemistry, 页码:11015-11024 , 文章类型: Article,,卷期:2011年50-51]
- For inner mitochondrial membrane (IMM) proteins that do not undergo N-terminal cleavage, the activity may occur in the absence of a receptor present in the mitochondrial membrane. One such protein is human 3 beta-hydroxy...
- Ligand-Specific Structural Changes in the Vitamin D Receptor in Solution
[作者:Singarapu, KK; Zhu, JG; Tonelli, M; Rao, HY; Assadi-Porter, FM; Westler, WM; DeLuca, HF; Markley, JL,期刊:Biochemistry, 页码:11025-11033 , 文章类型: Article,,卷期:2011年50-51]
- Vitamin D receptor (VDR) is a member of the nuclear hormone receptor superfamily. When bound to a variety of vitamin D analogues, VDR manifests a wide diversity of physiological actions. The molecular mechanism by which ...
- Double Reduction of Plastoquinone to Plastoquinol in Photosystem 1
[作者:McConnell, MD; Cowgill, JB; Baker, PL; Rappaport, F; Redding, KE,期刊:Biochemistry, 页码:11034-11046 , 文章类型: Article,,卷期:2011年50-51]
- In Photosystem 1 (PS1), phylloquinone (PhQ) acts as a secondary electron acceptor from chlorophyll ec(3) and also as an electron donor to the iron-sulfur cluster F(x). PSI possesses two virtually equivalent branches of e...
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