- Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: Implications for diabetic ventricular dysfunction after myocardial infarction
[作者:Shishido, T; Woo, CH; Ding, B; McClain, C; Molina, CA; Yan, C; Yang, J; Abe, J,期刊:Circulation Research, 页码:1416-1425 , 文章类型: Article,,卷期:2008年102-11]
- Diabetes mellitus (DM) contributes to the exacerbation of left ventricle (LV) dysfunction after myocardial infarction (MI). Activation of ERK5, an atypical mitogen activated protein kinase with transcriptional activity, ...
- Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system
[作者:Bakker, ML; Boukens, BJ; Mommersteeg, MTM; Brons, JF; Wakker, V; Moorman, AFM; Christoffels, VM,期刊:Circulation Research, 页码:1340-1349 , 文章类型: Article,,卷期:2008年102-11]
- The cardiac conduction system consists of distinctive heart muscle cells that initiate and propagate the electric impulse required for coordinated contraction. The conduction system expresses the transcriptional represso...
- Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion
[作者:Caprio, M; Newfell, BG; la Sala, A; Baur, W; Fabbri, A; Rosano, G; Mendelsohn, ME; Jaffe, IZ,期刊:Circulation Research, 页码:1359-1367 , 文章类型: Article,,卷期:2008年102-11]
- In clinical trials, aldosterone antagonists decrease cardiovascular mortality and ischemia by unknown mechanisms. The steroid hormone aldosterone acts by binding to the mineralocorticoid receptor (MR), a ligand-activated...
- Pharmacological inhibition of Na/Ca exchange results in increased cellular Ca2+ load attributable to the predominance of forward mode block
[作者:Ozdemir, S; Bito, V; Holemans, P; Vinet, L; Mercadier, JJ; Varro, A; Sipido, KR,期刊:Circulation Research, 页码:1398-1405 , 文章类型: Article,,卷期:2008年102-11]
- Block of Na/Ca exchange (NCX) has potential therapeutic applications, in particular, if a mode-selective block could be achieved, but also carries serious risks for disturbing the normal Ca2+ balance maintained by NCX. W...
- A missense mutation in the CHRM2 gene is associated with familial dilated cardiomyopathy
[作者:Zhang, L; Hu, AH; Yuan, HX; Cui, L; Miao, GB; Yang, XC; Wang, LF; Liu, JC; Liu, XL; Wang, SY; Zhang, ZY; Liu, LS; Zhao, RR; Shen, Y,期刊:Circulation Research, 页码:1426-1432 , 文章类型: Article,,卷期:2008年102-11]
- Circulating autoantibodies against the M2-muscarinic acetylcholine receptor (CHRM2) have been detected in patients with dilated cardiomyopathy (DCM). However, it has yet to be determined whether the pathogenesis of famil...
- Adventitial mast cells contribute to pathogenesis in the progression of abdominal aortic aneurysm
[作者:Tsuruda, T; Kato, J; Hatakeyama, K; Kojima, K; Yano, M; Yano, Y; Nakamura, K; Nakamura-Uchiyama, F; Matsushima, Y; Imamura, T; Onitsuka, T; Asada, Y; Nawa, Y; Eto, T; Kitamura, K,期刊:Circulation Research, 页码:1368-1377 , 文章类型: Article,,卷期:2008年102-11]
- Abdominal aortic aneurysm (AAA) is histologically characterized by medial degeneration and various degrees of chronic adventitial inflammation, although the mechanisms for progression of aneurysm are poorly understood. I...
- Interaction of alpha(1)-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel
[作者:O-Uchi, J; Sasaki, H; Morimoto, S; Kusakari, Y; Shinji, H; Obata, T; Hongo, K; Komukai, K; Kurihara, S,期刊:Circulation Research, 页码:1378-1388 , 文章类型: Article,,卷期:2008年102-11]
- We examined the effect of alpha(1)-adrenoceptor subtype-specific stimulation on L-type Ca2+ current (I-Ca) and elucidated the subtype-specific intracellular mechanisms for the regulation of L-type Ca2+ channels in isolat...
- Distinct cellular and molecular mechanisms underlie functional remodeling of repolarizing K+ currents with left ventricular hypertrophy
[作者:Marionneau, C; Brunet, S; Flagg, TP; Pilgram, TK; Demolombe, S; Nerbonne, JM,期刊:Circulation Research, 页码:1406-1415 , 文章类型: Article,,卷期:2008年102-11]
- Left ventricular hypertrophy (LVH) is associated with electric remodeling and increased arrhythmia risk, although the underlying mechanisms are poorly understood. In the experiments here, functional voltage-gated (Kv) an...
- A gain-of-function TBX5 mutation is associated with atypical Holt-Oram syndrome and paroxysmal atrial fibrillation
[作者:Postma, AV; van de Meerakker, JBA; Mathijssen, IB; Barnett, P; Christoffels, VM; Ilgun, A; Lam, J; Wilde, AAM; Deprez, RHL; Moorman, AFM,期刊:Circulation Research, 页码:1433-1442 , 文章类型: Article,,卷期:2008年102-11]
- Holt-Oram syndrome (HOS) is a heart/hand syndrome clinically characterized by upper limb and cardiac malformations. Mutations in T-box transcription factor 5 (TBX5) underlie this syndrome. Here, we describe a large atypi...
- Cell-free embryonic stem cell extract-mediated derivation of multipotent stem cells from NIH3T3 fibroblasts for functional and anatomical ischemic tissue repair
[作者:Rajasingh, J; Lambers, E; Hamada, H; Bord, E; Thorne, T; Goukassian, I; Krishnamurthy, P; Rosen, KM; Ahluwalia, D; Zhu, Y; Qin, GJ; Losordo, DW; Kishore, R,期刊:Circulation Research, 页码:E107-E117 , 文章类型: Article,,卷期:2008年102-11]
- The oocyte-independent source for the generation of pluripotent stem cells is among the ultimate goals in regenerative medicine. We report that on exposure to mouse embryonic stem cell (mESC) extracts, reversibly permeab...
- Arrhythmogenic effects of beta(2)-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load
[作者:DeSantiago, J; Ai, X; Islam, M; Acuna, G; Ziolo, MT; Bers, DM; Pogwizd, SM,期刊:Circulation Research, 页码:1389-1397 , 文章类型: Article,,卷期:2008年102-11]
- Ventricular tachycardia in heart failure (HF) can initiate by nonreentrant mechanisms such as delayed afterdepolarizations. In an arrhythmogenic rabbit model of HF, we have shown that isoproterenol induces ventricular ta...
|