- Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1
[作者:Sawada, N; Salomone, S; Kim, HH; Kwiatkowski, DJ; Liao, JK,期刊:Circulation Research, 页码:360-368 , 文章类型: Article,,卷期:2008年103-4]
- Diminished bioavailability of nitric oxide is a hallmark of endothelial dysfunction and is associated with a broad spectrum of vascular disorders such as impaired angiogenesis. Because Rac1, a Rho family member, mediates...
- Lidocaine-induced Brugada syndrome phenotype linked to a novel double mutation in the cardiac sodium channel
[作者:Barajas-Martinez, HM; Hu, D; Cordeiro, JM; Wu, Y; Kovacs, RJ; Meltser, H; Kui, H; Elena, B; Brugada, R; Antzelevitch, C; Dumaine, R,期刊:Circulation Research, 页码:396-404 , 文章类型: Article,,卷期:2008年103-4]
- Brugada syndrome has been linked to mutations in SCN5A. Agents that dissociate slowly from the sodium channel such as flecainide and ajmaline unmask the Brugada syndrome electrocardiogram and precipitate ventricular tach...
- Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis
[作者:Eyries, M; Siegfried, G; Ciumas, M; Montagne, K; Agrapart, M; Lebrin, F; Soubrier, F,期刊:Circulation Research, 页码:432-440 , 文章类型: Article,,卷期:2008年103-4]
- Apelin has been identified as the endogenous ligand of the human orphan G protein-coupled receptor APJ. This peptide exerts a variety of cardiovascular effects and particularly acts as an activator of angiogenesis. Impor...
- Involvement of heat shock factor 1 in statin-induced transcriptional upregulation of endothelial thrombomodulin
[作者:Fu, Q; Wang, JR; Boerma, M; Berbee, M; Qiu, XH; Fink, LM; Hauer-Jensen, M,期刊:Circulation Research, 页码:369-377 , 文章类型: Article,,卷期:2008年103-4]
- Statins upregulate endothelial thrombomodulin (TM) by mechanisms that involve members of the Kruppel-like factor family. Although Kruppel-like factors are unequivocally implicated in this process, experimental evidence p...
- Homotypic and endothelial cell adhesions via N-cadherin determine polarity and regulate migration of vascular smooth muscle cells
[作者:Sabatini, PJB; Zhang, M; Silverman-Gavrila, R; Bendeck, MP; Langille, BL,期刊:Circulation Research, 页码:405-412 , 文章类型: Article,,卷期:2008年103-4]
- Migration of smooth muscle cells from the arterial media to the intima is central to several vascular pathologies including restenosis. This study demonstrates that, like directional migration of other cells, smooth musc...
- G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure
[作者:Raake, PW; Vinge, LE; Gao, EH; Boucher, M; Rengo, G; Chen, XW; DeGeorge, BR; Matkovich, S; Houser, SR; Most, P; Eckhart, AD; Dorn, GW; Koch, WJ,期刊:Circulation Research, 页码:413-422 , 文章类型: Article,,卷期:2008年103-4]
- Myocardial G protein-coupled receptor kinase (GRK)2 is a critical regulator of cardiac beta-adrenergic receptor (beta AR) signaling and cardiac function. Its upregulation in heart failure may further depress cardiac func...
- Transcriptional regulation during development of the ductus arteriosus
[作者:Ivey, KN; Sutcliffe, D; Richardson, J; Clyman, RI; Garcia, JA; Srivastava, D,期刊:Circulation Research, 页码:388-395 , 文章类型: Article,,卷期:2008年103-4]
- The ductus arteriosus is a specialized blood vessel containing highly differentiated and contractile vascular smooth muscle, derived largely from neural crest cells, that is essential for fetal life but typically closes ...
- Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations
[作者:Venkatesh, DA; Park, KS; Harrington, A; Miceli-Libby, L; Yoon, JK; Liaw, L,期刊:Circulation Research, 页码:423-431 , 文章类型: Article,,卷期:2008年103-4]
- Notch signaling is critical for the development and maintenance of the cardiovasculature, with loss-of-function studies defining roles of Notch1 in the endothelial/hematopoietic lineages. No in vivo studies have addresse...
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