- Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module
[作者:Humbert, PO; Grzeschik, NA; Brumby, AM; Galea, R; Elsum, I; Richardson, HE,期刊:Oncogene, 页码:6888-6907 , 文章类型: Review,,卷期:2008年27-55]
- The neoplastic tumour suppressors, Scribble, Dlg and Lgl, originally discovered in the vinegar fly Drosophila melanogaster, are currently being actively studied for their potential role in mammalian tumourigenesis. In Dr...
- LKB1; linking cell structure and tumor suppression
[作者:Hezel, AF; Bardeesy, N,期刊:Oncogene, 页码:6908-6919 , 文章类型: Review,,卷期:2008年27-55]
- Germ line mutations in the LKB1 tumor suppressor gene are associated with the Peutz-Jeghers polyposis and cancer syndrome. Somatic mutations in Lkb1 are observed in sporadic pulmonary, pancreatic and biliary cancers and ...
- Cadherins and cancer: how does cadherin dysfunction promote tumor progression?
[作者:Jeanes, A; Gottardi, CJ; Yap, AS,期刊:Oncogene, 页码:6920-6929 , 文章类型: Review,,卷期:2008年27-55]
- It has long been recognized that the cell-cell adhesion receptor, E-cadherin, is an important determinant of tumor progression, serving as a suppressor of invasion and metastasis in many contexts. Yet how the loss of E-c...
- Tight junction-based epithelial microenvironment and cell proliferation
[作者:Tsukita, S; Yamazaki, Y; Katsuno, T; Tamura, A; Tsukita, S,期刊:Oncogene, 页码:6930-6938 , 文章类型: Review,,卷期:2008年27-55]
- Belt-like tight junctions (TJs), referred to as zonula occludens, have long been regarded as a specialized differentiation of epithelial cell membranes. They are required for cell adhesion and paracellular barrier functi...
- Polarity proteins in migration and invasion
[作者:Etienne-Manneville, S,期刊:Oncogene, 页码:6970-6980 , 文章类型: Review,,卷期:2008年27-55]
- Cancer is the result of the deregulation of cell proliferation and cell migration. In advanced tumors, cells invade the surrounding tissue and eventually form metastases. This is particularly evident in carcinomas in whi...
- Biomechanical regulation of cell orientation and fate
[作者:Lopez, JI; Mouw, JK; Weaver, VM,期刊:Oncogene, 页码:6981-6993 , 文章类型: Review,,卷期:2008年27-55]
- Biomechanical regulation of tumor phenotypes have been noted for several decades, yet the function of mechanics in the co-evolution of the tumor epithelium and altered cancer extracellular matrix has not been appreciated...
- Drosophila asymmetric division, polarity and cancer
[作者:Januschke, J; Gonzalez, C,期刊:Oncogene, 页码:6994-7002 , 文章类型: Review,,卷期:2008年27-55]
- A limited number of adult stem cells (SCs) maintain the homoestasis of different tissues through the lifetime of the individual by generating differentiating daughters and renewing themselves. Errors in the SC division r...
- Human papillomaviruses, cervical cancer and cell polarity
[作者:Thomas, M; Narayan, N; Pim, D; Tomaic, V; Massimi, P; Nagasaka, K; Kranjec, C; Gammoh, N; Banks, L,期刊:Oncogene, 页码:7018-7030 , 文章类型: Review,,卷期:2008年27-55]
- Human papillomaviruses (HPVs) are the causative agents of a number of human cancers, of which cervical cancer is the most important. This occurs following persistent infection with a limited number of viral subtypes and ...
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