- Phosphoinositides Affect both the Cellular Distribution and Activity of the F-BAR-containing RhoGAP Rgd1p in Yeast
[作者:Prouzet-Mauleon, V; Lefebvre, F; Thoraval, D; Crouzet, M; Doignon, F,期刊:Journal of Biological Chemistry, 页码:33249-33257 , 文章类型: Article,,卷期:2008年283-48]
- Cell polarity is a key element of development in most eukaryotes. The Rho GTPase-activating protein Rgd1p positively regulates the GTPase activity of Rho3p and Rho4p, which are involved in bud growth and cytokinesis, res...
- Binding of MG132 or Deletion of the Thr Active Sites in HslV Subunits Increases the Affinity of HslV Protease for HslU ATPase and Makes This Interaction Nucleotide-independent
[作者:Park, E; Lee, JW; Eom, SH; Seol, JH; Chung, CH,期刊:Journal of Biological Chemistry, 页码:33258-33266 , 文章类型: Article,,卷期:2008年283-48]
- HslVU is an ATP-dependent protease in bacteria consisting of HslV dodecamer and HslU hexamer. Upon ATP binding, HslU ATPase allosterically activates the catalytic function of HslV protease by 1-2 orders of magnitude. How...
- Following the Path of a Twin-arginine Precursor along the TatABC Translocase of Escherichia coli
[作者:Panahandeh, S; Maurer, C; Moser, M; DeLisa, MP; Muller, M,期刊:Journal of Biological Chemistry, 页码:33267-33275 , 文章类型: Article,,卷期:2008年283-48]
- The twin-arginine translocation (Tat) machinery present in bacterial and thylakoidal membranes is able to transport fully folded proteins. Consistent with previous in vivo data, we show that the model Tat substrate TorA-...
- Ricin B Chain Targeted to the Endoplasmic Reticulum of Tobacco Protoplasts Is Degraded by a CDC48-and Vacuole-independent Mechanism
[作者:Chamberlain, KL; Marshall, RS; Jolliffe, NA; Frigerio, L; Ceriotti, A; Lord, JM; Roberts, LM,期刊:Journal of Biological Chemistry, 页码:33276-33286 , 文章类型: Article,,卷期:2008年283-48]
- The B chain of ricin was expressed and delivered to the endoplasmic reticulum of tobacco protoplasts where it disappeared with time in a manner consistent with degradation. This turnover did not occur in the vacuoles or ...
- Distinct Pharmacological Effects of Inhibitors of Signal Peptide Peptidase and gamma-Secretase
[作者:Sato, T; Ananda, K; Cheng, CI; Suh, EJ; Narayanan, S; Wolfe, MS,期刊:Journal of Biological Chemistry, 页码:33287-33295 , 文章类型: Article,,卷期:2008年283-48]
- Signal peptide peptidase (SPP) and gamma-secretase are intramembrane aspartyl proteases that bear similar active site motifs but with opposite membrane topologies. Both proteases are inhibited by the same aspartyl protea...
- Phosphoinositide 3-Kinases gamma and delta, Linkers of Coordinate C5a Receptor-Fc gamma Receptor Activation and Immune Complex-induced Inflammation
[作者:Konrad, S; Ali, SR; Wiege, K; Syed, SN; Engling, L; Piekorz, RP; Hirsch, E; Nurnberg, B; Schmidt, RE; Gessner, JE,期刊:Journal of Biological Chemistry, 页码:33296-33303 , 文章类型: Article,,卷期:2008年283-48]
- Fc gamma receptors (Fc gamma R) and the C5a receptor (C5aR) are key effectors of the acute inflammatory response to IgG immune complexes (IC). Their coordinated activation is critical in IC-induced diseases, although the...
- C-terminal Tail of FGF19 Determines Its Specificity toward Klotho Co-receptors
[作者:Wu, XL; Lemon, B; Li, XF; Gupte, J; Weiszmann, J; Stevens, J; Hawkins, N; Shen, WY; Lindberg, R; Chen, JL; Tian, H; Li, Y,期刊:Journal of Biological Chemistry, 页码:33304-33309 , 文章类型: Article,,卷期:2008年283-48]
- FGF19 subfamily proteins (FGF19, FGF21, and FGF23) are unique members of fibroblast growth factors (FGFs) that regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis in an endocrine fashion. The...
- Pigment Epithelium-derived Factor Binds to Hyaluronan MAPPING OF A HYALURONAN BINDING SITE
[作者:Becerra, SP; Perez-Mediavilla, LA; Weldon, JE; Locatelli-Hoops, S; Senanayake, P; Notari, L; Notario, V; Hollyfield, JG,期刊:Journal of Biological Chemistry, 页码:33310-33320 , 文章类型: Article,,卷期:2008年283-48]
- Pigment epithelium-derived factor (PEDF) is a multifunctional serpin with antitumorigenic, antimetastatic, and differentiating activities. PEDF is found within tissues rich in the glycosaminoglycan hyaluronan (HA), and i...
- The Solution Structure of DNA-free Pax-8 Paired Box Domain Accounts for Redox Regulation of Transcriptional Activity in the Pax Protein Family
[作者:Codutti, L; van Ingen, H; Vascotto, C; Fogolari, F; Corazza, A; Tell, G; Quadrifoglio, F; Viglino, P; Boelens, R; Esposito, G,期刊:Journal of Biological Chemistry, 页码:33321-33328 , 文章类型: Article,,卷期:2008年283-48]
- Pax-8 is a transcription factor belonging to the PAX genes superfamily and its crucial role has been proven both in embryo and in the adult organism. Pax-8 activity is regulated via a redox-based mechanism centered on th...
- The Third Intracellular Loop Stabilizes the Inactive State of the Neuropeptide Y1 Receptor
[作者:Chee, MJS; Morl, K; Lindner, D; Merten, N; Zamponi, GW; Light, PE; Beck-Sickinger, AG; Colmers, WF,期刊:Journal of Biological Chemistry, 页码:33337-33346 , 文章类型: Article,,卷期:2008年283-48]
- Constitutively active G-protein-coupled receptors (GPCRs) can signal even in the absence of ligand binding. Most Class I GPCRs are stabilized in the resting conformation by intramolecular interactions involving transmemb...
- Selective Actions of Mitochondrial Fission/Fusion Genes on Metabolism-Secretion Coupling in Insulin-releasing Cells
[作者:Park, KS; Wiederkehr, A; Kirkpatrick, C; Mattenberger, Y; Martinou, JC; Marchetti, P; Demaurex, N; Wollheim, CB,期刊:Journal of Biological Chemistry, 页码:33347-33356 , 文章类型: Article,,卷期:2008年283-48]
- Mitochondria form filamentous networks that undergo continuous fission/fusion. In the pancreatic beta-cells, mitochondria are essential for the transduction of signals linking nutrient metabolism to insulin granule exocy...
- Identification of Neutral Cholesterol Ester Hydrolase, a Key Enzyme Removing Cholesterol from Macrophages
[作者:Okazaki, H; Igarashi, M; Nishi, M; Sekiya, M; Tajima, M; Takase, S; Takanashi, M; Ohta, K; Tamura, Y; Okazaki, S; Yahagi, N; Ohashi, K; Amemiya-Kudo, M; Nakagawa, Y; Nagai, R; Kadowaki, T; Osuga, J; Ishibashi, S,期刊:Journal of Biological Chemistry, 页码:33357-33364 , 文章类型: Article,,卷期:2008年283-48]
- Unstable lipid-rich plaques in atherosclerosis are characterized by the accumulation of macrophage foam cells loaded with cholesterol ester (CE). Although hormone-sensitive lipase and cholesteryl ester hydrolase (CEH) ha...
- Huntingtin-interacting Proteins, HIP14 and HIP14L, Mediate Dual Functions, Palmitoyl Acyltransferase and Mg2+ Transport
[作者:Goytain, A; Hines, RM; Quamme, GA,期刊:Journal of Biological Chemistry, 页码:33365-33374 , 文章类型: Article,,卷期:2008年283-48]
- Polyglutamine expansions of huntingtin protein are responsible for the Huntington neurological disorder. HIP14 protein has been shown to interact with huntingtin. HIP14 and a HIP14-like protein, HIP14L, with a 69% simila...
- Design of a Conformationally Defined and Proteolytically Stable Circular Mimetic of Brain-derived Neurotrophic Factor
[作者:Fletcher, JM; Morton, CJ; Zwar, RA; Murray, SS; O'Leary, PD; Hughes, RA,期刊:Journal of Biological Chemistry, 页码:33375-33383 , 文章类型: Article,,卷期:2008年283-48]
- Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of neurotrophic factors. BDNF has long been recognized to have potential for the treatment of a variety of human neurodegenerative diseases....
- Removal of the N-terminal Extension of Cardiac Troponin I as a Functional Compensation for Impaired Myocardial beta-Adrenergic Signaling
[作者:Feng, HZ; Chen, M; Weinstein, LS; Jin, JP,期刊:Journal of Biological Chemistry, 页码:33384-33393 , 文章类型: Article,,卷期:2008年283-48]
- Although beta-adrenergic stimuli are essential for myocardial contractility, beta-blockers have a proven beneficial effect on the treatment of heart failure, but the mechanism is not fully understood. The stimulatory G p...
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