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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共36条记录   The repertoire of lambda light chains causing predominant amyloid heart involvement and identification of a preferentially involved germline gene, IGLV1-44 [作者：Perfetti, V; Palladini, G; Casarini, S; Navazza, V; Rognoni, P; Obici, L; Invernizzi, R; Perlini, S; Klersy, C; Merlini, G,期刊：Blood, 页码：144-150 , 文章类型： Article，,卷期：2012年119-1] Monoclonal Ig light chains (LC) can be responsible for pathologic conditions in humans, as in systemic amyloid light amyloidosis. Protean clinical manifestations characterize this disorder with the most varied combinatio... Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program [作者：Boxus, M; Twizere, JC; Legros, S; Kettmann, R; Willems, L,期刊：Blood, 页码：151-160 , 文章类型： Article，,卷期：2012年119-1] The Tax oncoprotein encoded by the human T-cell leukemia virus type 1 plays a pivotal role in viral persistence and pathogenesis. Human T-cell leukemia virus type 1-infected cells proliferate faster than normal lymphocyt... Novel treatment concepts for graft-versus-host disease [作者：Wolf, D; von Lilienfeld-Toal, M; Wolf, AM; Schleuning, M; von Bergwelt-Baildon, M; Held, SAE; Brossart, P,期刊：Blood, 页码：16-25 , 文章类型： Review，,卷期：2012年119-1] Acute and chronic graft-versus-host disease (GVHD) are potentially lethal complications after stem cell transplantation (SCT). Steroids are the appropriate first-line treatment for both. However, if patients do not adequ... Maturation and function of human dendritic cells are regulated by B lymphocytes [作者：Morva, A; Lemoine, S; Achour, A; Pers, JO; Youinou, P; Jamin, C,期刊：Blood, 页码：106-114 , 文章类型： Article，,卷期：2012年119-1] Mature dendritic cells (DCs) are stimulators of T-cell immune response, whereas immature DCs support T-cell tolerance. Murine B cells can inhibit the production of IL-12 by DCs and thereby hinder the inflammatory respons... Inhibition of PPAR gamma in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis [作者：Wu, L; Yan, C; Czader, M; Foreman, O; Blum, JS; Kapur, R; Du, H,期刊：Blood, 页码：115-126 , 文章类型： Article，,卷期：2012年119-1] Peroxisome proliferator-activated receptor-gamma (PPAR gamma) is an anti-inflammatory molecule. To study its biologic function in myeloid cells, dominant-negative PPAR gamma (dnPPAR gamma) was overexpressed in a myeloid-... Critical role for perforin and Fas-dependent killing of dendritic cells in the control of inflammation [作者：Chen, M; Felix, K; Wang, J,期刊：Blood, 页码：127-136 , 文章类型： Article，,卷期：2012年119-1] After stimulation of antigen-specific T cells, dendritic cell (DCs) are susceptible to killing by these activated T cells that involve perforin and Fas-dependent mechanisms. Fas-dependent DC apoptosis has been shown to l... Increased serum soluble IL-15R alpha levels in T-cell large granular lymphocyte leukemia [作者：Chen, J; Petrus, M; Bamford, R; Shih, JH; Morris, JC; Janik, JE; Waldmann, TA,期刊：Blood, 页码：137-143 , 文章类型： Article，,卷期：2012年119-1] Large granular lymphocyte (LGL) leukemia is a clonal lymphoproliferative disease of mature T and natural killer cells. The etiology of LGL leukemia is unknown. IL-15 is an inflammatory cytokine that stimulates T and natu... Active vaccination with Dickkopf-1 induces protective and therapeutic antitumor immunity in murine multiple myeloma [作者：Qian, JF; Zheng, YH; Zheng, CY; Wang, LJ; Qin, H; Hong, SY; Li, HY; Lu, Y; He, J; Yang, J; Neelapu, S; Kwak, LW; Hou, J; Yi, Q,期刊：Blood, 页码：161-169 , 文章类型： Article，,卷期：2012年119-1] Dickkopf-1 (DKK1), broadly expressed in myeloma cells but highly restricted in normal tissues, together with its functional roles as an osteoblast formation inhibitor, may be an ideal target for immunotherapy in myeloma.... Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells [作者：Krysov, S; Dias, S; Paterson, A; Mockridge, CI; Potter, KN; Smith, KA; Ashton-Key, M; Stevenson, FK; Packham, G,期刊：Blood, 页码：170-179 , 文章类型： Article，,卷期：2012年119-1] Although long considered as a disease of failed apoptosis, it is now clear that chronic lymphocytic leukemia (CLL) cells undergo extensive cell division in vivo, especially in progressive disease. Signaling via the B-cel... Tcl 1 interacts with Atm and enhances NF-kappa B activation in hematologic malignancies [作者：Gaudio, E; Spizzo, R; Paduano, F; Luo, ZH; Efanov, A; Palamarchuk, A; Leber, AS; Kaou, M; Zanesi, N; Bottoni, A; Costinean, S; Rassenti, LZ; Nakamura, T; Kipps, TJ; Aqeilan, RI; Pekarsky, Y; Trapasso, F; Croce, CM,期刊：Blood, 页码：180-187 , 文章类型： Article，,卷期：2012年119-1] The T-cell leukemia/lymphoma 1 (TCL1) oncogene is a target of chromosomal translocations and inversions at 14q31.2, and its rearrangement in T cells causes T-cell prolymphocytic leukemias. TCL1 dysregulation in B cells i... The BRAF V600E mutation in hairy cell leukemia and other mature B-cell neoplasms [作者：Arcaini, L; Zibellini, S; Boveri, E; Riboni, R; Rattotti, S; Varettoni, M; Guerrera, ML; Lucioni, M; Tenore, A; Merli, M; Rizzi, S; Morello, L; Cavalloni, C; Da Via, MC; Paulli, M; Cazzola, M,期刊：Blood, 页码：188-191 , 文章类型： Article，,卷期：2012年119-1] The somatically acquired V600E mutation of the BRAF gene has been recently described as a molecular marker of hairy cell leukemia (HCL). We developed an allele-specific PCR for this mutation and studied 62 patients with ... Simple genetic diagnosis of hairy cell leukemia by sensitive detection of the BRAF-V600E mutation [作者：Tiacci, E; Schiavoni, G; Forconi, F; Santi, A; Trentin, L; Ambrosetti, A; Cecchini, D; Sozzi, E; di Celle, PF; Di Bello, C; Pulsoni, A; Foa, R; Inghirami, G; Falini, B,期刊：Blood, 页码：192-195 , 文章类型： Article，,卷期：2012年119-1] Hairy cell leukemia (HCL) is a distinct clinicopathologic entity that responds well to purine analogs but is sometimes difficult to differentiate from HCL-like disorders (eg, splenic marginal zone lymphoma and HCL varian... A functional variant in the core promoter of the CD95 cell death receptor gene predicts prognosis in acute promyelocytic leukemia [作者：Sunter, NJ; Scott, K; Hills, R; Grimwade, D; Taylor, S; Worrillow, LJ; Fordham, SE; Forster, VJ; Jackson, G; Bomken, S; Jones, G; Allan, JM,期刊：Blood, 页码：196-205 , 文章类型： Article，,卷期：2012年119-1] Up to 15% of acute promyelocytic leukemia (APL) patients fail to achieve or maintain remission. We investigated a common G > A polymorphism at position -1377 (rs2234767) in the core promoter of the CD95 cell death recept... Two genes, tipifarnib, and AML [作者：Ruchlemer, R,期刊：Blood, 页码：2-3 , 文章类型： Editorial Material，,卷期：2012年119-1] Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome inAML [作者：Treppendahl, MB; Qiu, XN; Sogaard, A; Yang, XJ; Nandrup-Bus, C; Hother, C; Andersen, MK; Kjeldsen, L; Mollgaard, L; Hellstrom-Lindberg, E; Jendholm, J; Porse, BT; Jones, PA; Liang, GN; Gronbaek, K,期刊：Blood, 页码：206-216 , 文章类型： Article，,卷期：2012年119-1] Deletions of chromosome 5q are associated with poor outcomes in acute myeloid leukemia (AML) suggesting the presence of tumor suppressor(s) at the locus. However, definitive identification of putative tumor suppressor ge... Purinergic signaling inhibits human acute myeloblastic leukemia cell proliferation, migration, and engraftment in immunodeficient mice [作者：Salvestrini, V; Zini, R; Rossi, L; Gulinelli, S; Manfredini, R; Bianchi, E; Piacibello, W; Caione, L; Migliardi, G; Ricciardi, MR; Tafuri, A; Romano, M; Salati, S; Di Virgilio, F; Ferrari, S; Baccarani, M; Ferrari, D; Lemoli, RM,期刊：Blood, 页码：217-226 , 文章类型： Article，,卷期：2012年119-1] Extracellular ATP and UTP nucleotides increase the proliferation and engraftment potential of normal human hematopoietic stem cells via the engagement of purinergic receptors (P2Rs). In the present study, we show that AT...