- Reactome Array: Forging a Link Between Metabolome and Genome
[作者:Beloqui, A; Guazzaroni, ME; Pazos, F; Vieites, JM; Godoy, M; Golyshina, OV; Chernikova, TN; Waliczek, A; Silva-Rocha, R; Al-ramahi, Y; La Cono, V; Mendez, C; Salas, JA; Solano, R; Yakimov, MM; Timmis, KN; Golyshin, PN; Ferrer, M,期刊:Science, 页码:252-257 , 文章类型: Article,,卷期:2009年326-5950]
- We describe a sensitive metabolite array for genome sequence-independent functional analysis of metabolic phenotypes and networks, the reactomes, of cell populations and communities. The array includes 1676 dye-linked su...
- Arterial-Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation
[作者:Herbert, SP; Huisken, J; Kim, TN; Feldman, ME; Houseman, BT; Wang, RA; Shokat, KM; Stainier, DYR,期刊:Science, 页码:294-298 , 文章类型: Article,,卷期:2009年326-5950]
- Blood vessels form de novo (vasculogenesis) or upon sprouting of capillaries from preexisting vessels (angiogenesis). With high-resolution imaging of zebrafish vascular development, we uncovered a third mode of blood ves...
- Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome
[作者:Lieberman-Aiden, E; van Berkum, NL; Williams, L; Imakaev, M; Ragoczy, T; Telling, A; Amit, I; Lajoie, BR; Sabo, PJ; Dorschner, MO; Sandstrom, R; Bernstein, B; Bender, MA; Groudine, M; Gnirke, A; Stamatoyannopoulos, J; Mirny, LA; Lander, ES; Dekker, J,期刊:Science, 页码:289-293 , 文章类型: Article,,卷期:2009年326-5950]
- We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. We constructed spatial proximity maps of the human genom...
- Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
[作者:Walker, LM; Phogat, SK; Chan-Hui, PY; Wagner, D; Phung, P; Goss, JL; Wrin, T; Simek, MD; Fling, S; Mitcham, JL; Lehrman, JK; Priddy, FH; Olsen, OA; Frey, SM; Hammond, PW; Kaminsky, S; Zamb, T; Moyle, M; Koff, WC; Poignard, P; Burton, DR,期刊:Science, 页码:285-289 , 文章类型: Article,,卷期:2009年326-5950]
- Broadly neutralizing antibodies (bNAbs), which develop over time in some HIV-1-infected individuals, define critical epitopes for HIV vaccine design. Using a systematic approach, we have examined neutralization breadth i...
- Daily Electrical Silencing in the Mammalian Circadian Clock
[作者:Belle, MDC; Diekman, CO; Forger, DB; Piggins, HD,期刊:Science, 页码:281-284 , 文章类型: Article,,卷期:2009年326-5950]
- Neurons in the brain's suprachiasmatic nuclei (SCNs), which control the timing of daily rhythms, are thought to encode time of day by changing their firing frequency, with high rates during the day and lower rates at nig...
- The Shape and Surface Variation of 2 Pallas from the Hubble Space Telescope
[作者:Schmidt, BE; Thomas, PC; Bauer, JM; Li, JY; McFadden, LA; Mutchler, MJ; Radcliffe, SC; Rivkin, AS; Russell, CT; Parker, JW; Stern, SA,期刊:Science, 页码:275-278 , 文章类型: Article,,卷期:2009年326-5950]
- We obtained Hubble Space Telescope images of 2 Pallas in September 2007 that reveal distinct color and albedo variations across the surface of this large asteroid. Pallas's shape is an ellipsoid with radii of 291 (+/- 9)...
- Persistent Currents in Normal Metal Rings
[作者:Bleszynski-Jayich, AC; Shanks, WE; Peaudecerf, B; Ginossar, E; von Oppen, F; Glazman, L; Harris, JGE,期刊:Science, 页码:272-275 , 文章类型: Article,,卷期:2009年326-5950]
- Quantum mechanics predicts that the equilibrium state of a resistive metal ring will contain a dissipationless current. This persistent current has been the focus of considerable theoretical and experimental work, but it...
- Repetitive Readout of a Single Electronic Spin via Quantum Logic with Nuclear Spin Ancillae
[作者:Jiang, L; Hodges, JS; Maze, JR; Maurer, P; Taylor, JM; Cory, DG; Hemmer, PR; Walsworth, RL; Yacoby, A; Zibrov, AS; Lukin, MD,期刊:Science, 页码:267-272 , 文章类型: Article,,卷期:2009年326-5950]
- Robust measurement of single quantum bits plays a key role in the realization of quantum computation and communication as well as in quantum metrology and sensing. We have implemented a method for the improved readout of...
- Genome Project Standards in a New Era of Sequencing
[作者:Chain, PSG; Grafham, DV; Fulton, RS; FitzGerald, MG; Hostetler, J; Muzny, D; Ali, J; Birren, B; Bruce, DC; Buhay, C; Cole, JR; Ding, Y; Dugan, S; Field, D; Garrity, GM; Gibbs, R; Graves, T; Han, CS; Harrison, SH; Highlander, S; Hugenholtz, P; Khouri, HM; ,期刊:Science, 页码:236-237 , 文章类型: Editorial Material,,卷期:2009年326-5950]
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- Unbiased Reconstruction of a Mammalian Transcriptional Network Mediating Pathogen Responses
[作者:Amit, I; Garber, M; Chevrier, N; Leite, AP; Donner, Y; Eisenhaure, T; Guttman, M; Grenier, JK; Li, WB; Zuk, O; Schubert, LA; Birditt, B; Shay, T; Goren, A; Zhang, XL; Smith, Z; Deering, R; McDonald, RC; Cabili, M; Bernstein, BE; Rinn, JL; Meissner, A; Roo,期刊:Science, 页码:257-263 , 文章类型: Article,,卷期:2009年326-5950]
- Models of mammalian regulatory networks controlling gene expression have been inferred from genomic data but have largely not been validated. We present an unbiased strategy to systematically perturb candidate regulators...
- Ice Age Terminations
[作者:Cheng, H; Edwards, RL; Broecker, WS; Denton, GH; Kong, XG; Wang, YJ; Zhang, R; Wang, XF,期刊:Science, 页码:248-252 , 文章类型: Article,,卷期:2009年326-5950]
- Th-230-dated oxygen isotope records of stalagmites from Sanbao Cave, China, characterize Asian Monsoon (AM) precipitation through the ends of the third-and fourthmost recent ice ages. As a result, AM records for the past...
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