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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共13条记录   Varespladib methyl in cardiovascular disease [作者：Rosenson, RS; Fraser, H; Trias, J; Hislop, C,期刊：Expert opinion on investigational drugs, 页码：1245-1255 , 文章类型： Editorial Material，,卷期：2010年19-10] Importance of the field: The high risk of recurrent cardiovascular events amongst patients with cardiovascular disease receiving evidence-based therapies has prompted investigations into complimentary treatments that may... The inhibitory GABA system as a therapeutic target for cognitive symptoms in schizophrenia: investigational agents in the pipeline [作者：Vinkers, CH; Mirza, NR; Olivier, B; Kahn, RS,期刊：Expert opinion on investigational drugs, 页码：1217-1233 , 文章类型： Review，,卷期：2010年19-10] Importance of the field: Cognitive impairments associated with schizophrenia include neuropsychological deficits in attention, working memory, learning and executive function. Because these cognitive deficits precede the... The long and winding road for the development of tasquinimod as an oral second-generation quinoline-3-carboxamide antiangiogenic drug for the treatment of prostate cancer [作者：Isaacs, JT,期刊：Expert opinion on investigational drugs, 页码：1235-1243 , 文章类型： Editorial Material，,卷期：2010年19-10] Importance of the field: Prostate cancer is the mostly commonly diagnosed non-skin cancer in males. The culmination of the last 70 years of clinical drug development has documented that androgen ablation plus taxane-base... Asimadoline in the treatment of irritable bowel syndrome [作者：Mangel, AW; Williams, VSL,期刊：Expert opinion on investigational drugs, 页码：1257-1264 , 文章类型： Editorial Material，,卷期：2010年19-10] Importance of the field: Irritable bowel syndrome (IBS) represents one of the most common gastrointestinal disorders, with the diarrhea-predominant form (D-IBS) representing an area of high unmet medical need. One diffic... Aliskiren: beyond blood pressure reduction [作者：Riccioni, G; Vitulano, N; Zanasi, A; Bellocci, F; d'Orazio, N,期刊：Expert opinion on investigational drugs, 页码：1265-1274 , 文章类型： Editorial Material，,卷期：2010年19-10] Importance of the field: Hypertension is one of the most important risk factors and causes of cardiovascular disease (CVD). From some years, renin-angiotensin-aldosterone system (RAAS) inhibitors such angiotensin convert... High-dose treosulfan in conditioning prior to hematopoietic stem cell transplantation [作者：Glowka, FK; Romanski, M; Wachowiak, J,期刊：Expert opinion on investigational drugs, 页码：1275-1295 , 文章类型： Editorial Material，,卷期：2010年19-10] Importance of the field: Despite the marked development in the field of preparative regimens prior to hematopoietic stem cell transplantation (HSCT) over the last decade, the search for a superior conditioning agent is s... Berberine: a potential phytochemical with multispectrum therapeutic activities [作者：Vuddanda, PR; Chakraborty, S; Singh, S,期刊：Expert opinion on investigational drugs, 页码：1297-1307 , 文章类型： Editorial Material，,卷期：2010年19-10] Importance of the field: The use of traditional medicines of natural origin is being encouraged for the treatment of chronic disorders, as synthetic drugs in such cases may cause unpredictable adverse effects. Berberine,... Investigational agents for Crohn's disease [作者：Cottone, M; Orlando, A; Renna, S,期刊：Expert opinion on investigational drugs, 页码：1147-1159 , 文章类型： Review，,卷期：2010年19-10] Importance of the field: Increased understanding of the biological mechanisms of Crohn's disease has opened the door to a large number of new molecules; some of these are approved for clinical use, while others remain un... No clinically relevant drug-drug interactions when dalcetrapib is co-administered with atorvastatin [作者：Derks, M; Abt, M; Parr, G; Meneses-Lorente, G; Young, AM; Phelan, M,期刊：Expert opinion on investigational drugs, 页码：1135-1145 , 文章类型： Article，,卷期：2010年19-10] Objectives: Dalcetrapib, which targets cholesteryl ester transfer protein, is in clinical development for prevention of cardiovascular events and is likely to be used concomitantly with statins. Two studies investigated ... Erythropoietin molecules to treat acute ischemic stroke: a translational dilemma! [作者：Lapchak, PA,期刊：Expert opinion on investigational drugs, 页码：1179-1186 , 文章类型： Review，,卷期：2010年19-10] Importance of the field: Since the realization that erythropoietin (EPO) molecules have 'neuroprotective' properties, they have been investigated as treatments for acute ischemic stroke (AIS), but not systematically. The... Investigational agents for the irritable bowel syndrome [作者：Ghaith, O; El-Halabi, M; Hashash, JG; Sharara, AI,期刊：Expert opinion on investigational drugs, 页码：1161-1178 , 文章类型： Review，,卷期：2010年19-10] Importance of the field: Irritable bowel syndrome (IBS) is a common disorder with significant health and economic consequences. The etiology of IBS is complex and appears to be multifactorial. Traditional IBS therapies h... Quetiapine: novel uses in the treatment of depressive and anxiety disorders [作者：Ravindran, AV; Al-Subaie, A; Abraham, G,期刊：Expert opinion on investigational drugs, 页码：1187-1204 , 文章类型： Review，,卷期：2010年19-10] Importance of the field: Quetiapine, an atypical antipsychotic, has been approved for the treatment of schizophrenia, acute mania, bipolar depression and unipolar major depression. However, it is often used (off-label) t... Molecular targeted therapy for patients with melanoma: the promise of MAPK pathway inhibition and beyond [作者：Sullivan, RJ; Atkins, MB,期刊：Expert opinion on investigational drugs, 页码：1205-1216 , 文章类型： Review，,卷期：2010年19-10] Importance of the field: Recent discoveries have expanded the understanding of the molecular signaling events critical to melanomagenesis and led to the development of targeted therapeutic agents that are revolutionizing...