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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   5-HT3 antagonists under development [作者：Chong, Y; Choo, H,期刊：Expert opinion on investigational drugs, 页码：1309-1319 , 文章类型： Review，,卷期：2010年19-11] Importance of the field: The main therapeutic area of 5-HT3 receptor antagonists is the treatment of chemotherapy-induced nausea and vomiting (CINV), which is the most common and distressing side effects of anticancer tr... Overcoming platinum resistance in ovarian carcinoma [作者：Matsuo, K; Lin, YG; Roman, LD; Sood, AK,期刊：Expert opinion on investigational drugs, 页码：1339-1354 , 文章类型： Review，,卷期：2010年19-11] Importance of the field: Ovarian cancer remains a deadly malignancy because most patients develop recurrent disease that is resistant to chemotherapy, including platinum. Because response rates for current treatment regi... Akt inhibitors in clinical development for the treatment of cancer [作者：Pal, SK; Reckamp, K; Yu, H; Figlin, RA,期刊：Expert opinion on investigational drugs, 页码：1355-1366 , 文章类型： Review，,卷期：2010年19-11] Importance of the field: The evolution of targeted therapies is dependent upon identification of cellular moieties that can be pharmacologically modulated. As one such example, the serine-threonine kinase Akt was identif... Tumor vasculature as target for therapeutic intervention [作者：Fens, MHAM; Storm, G; Schiffelers, RM,期刊：Expert opinion on investigational drugs, 页码：1321-1338 , 文章类型： Review，,卷期：2010年19-11] Importance of the field: Solid tumors rely on efficient oxygen and nutrients transport for their growth, development and survival. Many tumors can stimulate new blood vessel formation. Because this angiogenic vasculature... Novel therapeutic strategies targeting vascular endothelium in essential hypertension [作者：Tousoulis, D; Papageorgiou, N; Androulakis, E; Paroutoglou, K; Stefanadis, C,期刊：Expert opinion on investigational drugs, 页码：1395-1412 , 文章类型： Review，,卷期：2010年19-11] Importance of the field: Several studies have demonstrated the high prevalence of hypertension and the crucial role of the association between endothelial function and hypertension. Thus, in depth investigation of the pa... Pharmacological small molecules for the treatment of lysosomal storage disorders [作者：Smid, BE; Aerts, JMFG; Boot, RG; Linthorst, GE; Hollak, CEM,期刊：Expert opinion on investigational drugs, 页码：1367-1379 , 文章类型： Review，,卷期：2010年19-11] Importance of the field: Inherited lysosomal storage diseases often cause severe disability and have a devastating effect on quality of life. Enzyme replacement therapy (ERT) forms a cornerstone in the treatment of lysos... Targeting the MET oncogene in cancer and metastases [作者：Stella, GM; Benvenuti, S; Comoglio, PM,期刊：Expert opinion on investigational drugs, 页码：1381-1394 , 文章类型： Review，,卷期：2010年19-11] Importance of the field: 'Invasive growth' is a genetic program involved in embryonic development and adult organ regeneration and usurped by cancer cells. Although its control is complex, tumor-and context-specific and ... Temporal aspects of the action of ASA404 (vadimezan; DMXAA) [作者：Baguley, BC; Siemann, DW,期刊：Expert opinion on investigational drugs, 页码：1413-1425 , 文章类型： Editorial Material，,卷期：2010年19-11] Importance of the field: Tumor vascular disrupting agents (tumor VDAs) act by selective induction of tumor vascular failure. While their action is distinct from that of antiangiogenic agents, their clinical potential is ... Avanafil, a new rapid-onset phosphodiesterase 5 inhibitor for the treatment of erectile dysfunction [作者：Limin, M; Johnsen, N; Hellstrom, WJG,期刊：Expert opinion on investigational drugs, 页码：1427-1437 , 文章类型： Editorial Material，,卷期：2010年19-11] Importance of the field: Erectile dysfunction (ED) is a common sexual problem, affecting up to half of men over 50 years of age. Phosphodiesterase type 5 (PDE5) inhibitors (sildenafil, tadalafil and vardenafil) are curre... Resolvin inflammation with pain [作者：Doggrell, SA,期刊：Expert opinion on investigational drugs, 页码：1461-1464 , 文章类型： Editorial Material，,卷期：2010年19-11] Background: Inflammation and pain coexist in conditions such as arthritis, inflammatory bowel disease and lower back pain. The drugs currently used to treat the combination of inflammation and pain all have disadvantages... PLX4032: does it keep its promise for metastatic melanoma treatment? [作者：Livingstone, E; Zimmer, L; Piel, S; Schadendorf, D,期刊：Expert opinion on investigational drugs, 页码：1439-1449 , 文章类型： Editorial Material，,卷期：2010年19-11] Importance of the field: Activating mutations in the BRAF kinase gene have been identified in 50% of all melanomas. PLX4032, a selective and potent inhibitor of BRAF V600E mutant tumor cells, has shown inhibition of tumo... Nalmefene for treatment of alcohol dependence [作者：Soyka, M; Rosner, S,期刊：Expert opinion on investigational drugs, 页码：1451-1459 , 文章类型： Editorial Material，,卷期：2010年19-11] Importance of the field: Alcohol use and dependence are frequent disorders. Despite numerous established psychosocial approaches, relapse to heavy drinking is common in alcohol-dependent patients after detoxification and...