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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共11条记录   A new paradigm for managing dyslipidemia with combination therapy: laropiprant plus niacin plus simvastatin [作者：Yiu, KH; Cheung, BMY; Tse, HF,期刊：Expert opinion on investigational drugs, 页码：437-449 , 文章类型： Editorial Material，,卷期：2010年19-3] Importance of the field: Despite effective lowering of low-density lipoprotein cholesterol (LDL-C) with statin for prevention of cardiovascular adverse events, residual risk remains high due to low high-density lipoprote... Lestaurtinib, a multitargeted tyrosinse kinase inhibitor: from bench to bedside [作者：Shabbir, M; Stuart, R,期刊：Expert opinion on investigational drugs, 页码：427-436 , 文章类型： Editorial Material，,卷期：2010年19-3] Importance of the field: Internal tandem duplication of the fms-like tyrosine kinase 3 (FLT3) gene (FLT3-ITD) is a common recurring mutation in acute myeloid leukemia (AML) with normal karyotype, and the presence of FLT3... The hedgehog pathway inhibitor GDC-0449 shows potential in skin and other cancers [作者：Doggrell, SA,期刊：Expert opinion on investigational drugs, 页码：451-454 , 文章类型： Editorial Material，,卷期：2010年19-3] Background: The hedgehog signalling pathway is vital in early development, but then becomes dormant, except in some cancer tumours. Hedgehog inhibitors are being developed for potential use in cancer. Objectives/methods:... Novel targets for the treatment of autosomal dominant polycystic kidney disease [作者：Belibi, FA; Edelstein, CL,期刊：Expert opinion on investigational drugs, 页码：315-328 , 文章类型： Review，,卷期：2010年19-3] Areas covered in the review: The purpose of this review is to summarize the molecular and cellular targets involved in cystogenesis and to update on the promising therapies that are being developed and tested based on kn... New microtubule-inhibiting anticancer agents [作者：Chen, SM; Meng, LH; Ding, J,期刊：Expert opinion on investigational drugs, 页码：329-343 , 文章类型： Review，,卷期：2010年19-3] What the reader will gain: This review mainly describes new microtubule-targeting anticancer agents that have been discovered (especially over the past 2 years), with emphasis on their diversity of structures and distinc... Colorectal cancer in review: the role of the EGFR pathway [作者：Saif, MW,期刊：Expert opinion on investigational drugs, 页码：357-369 , 文章类型： Review，,卷期：2010年19-3] Areas covered in this review: Our aim is to discuss the recent progress in the role of the EGFR pathway, the status of anti-EGFR therapeutic agents currently in use and the rationale for the development of novel agents t... Investigational therapies for non-muscle invasive bladder cancer [作者：Smaldone, MC; Casella, DP; Welchons, DR; Gingrich, JR,期刊：Expert opinion on investigational drugs, 页码：371-383 , 文章类型： Review，,卷期：2010年19-3] Importance of the field: Bacillus Calmette-Guerin (BCG) is currently the most effective adjuvant intravesical agent at preventing disease recurrence and the only therapy shown to inhibit disease progression in non-muscle... Anti-chemokine small molecule drugs: a promising future? [作者：Proudfoot, AEI; Power, CA; Schwarz, MK,期刊：Expert opinion on investigational drugs, 页码：345-355 , 文章类型： Review，,卷期：2010年19-3] Areas covered in this review: Although there are now a large number of molecules targeting chemokines and chemokine receptors including neutralizing antibodies in clinical trials for inflammatory diseases, the results to... Macrolide antibiotics and the airway: antibiotic or non-antibiotic effects? [作者：Murphy, DM; Forrest, IA; Curran, D; Ward, C,期刊：Expert opinion on investigational drugs, 页码：401-414 , 文章类型： Review，,卷期：2010年19-3] Importance of the field: The macrolides are a class of antibiotics widely prescribed in infectious disease. More recently, there has been considerable interest in potential indications for these agents, in addition to th... Dasatinib in solid tumors [作者：Kim, LC; Rix, U; Haura, EB,期刊：Expert opinion on investigational drugs, 页码：415-425 , 文章类型： Editorial Material，,卷期：2010年19-3] Importance of the field: Dasatinib is an oral, potent adenosine triphosphate-competitive inhibitor of multiple tyrosine kinases including BCR-ABL, c-KIT, platelet-derived growth factor receptor, and Src family kinases (S... The somatostatin receptor subtype 5 in neuroendocrine tumours [作者：van der Hoek, J; Lamberts, SWJ; Hofland, LJ,期刊：Expert opinion on investigational drugs, 页码：385-399 , 文章类型： Review，,卷期：2010年19-3] Importance of the field: In recent years, scientific work has been intensified to unravel new (patho-) physiological insights, particularly regarding the functional role of somatostatin (SRIF) receptor subtype 5 (sst) an...