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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共9条记录   Novel dual Src/Abl inhibitors for hematologic and solid malignancies [作者：Schenone, S; Brullo, C; Musumeci, F; Botta, M,期刊：Expert opinion on investigational drugs, 页码：931-945 , 文章类型： Review，,卷期：2010年19-8] Importance of the field: c-Src and Bcr-Abl are two non-receptor or cytoplasmic tyrosine kinases (TKs) that play important roles in the development of solid and hematological malignancies. Indeed, Src is overexpressed or ... Metformin and cancer: licence to heal? [作者：Papanas, N; Maltezos, E; Mikhailidis, DP,期刊：Expert opinion on investigational drugs, 页码：913-917 , 文章类型： Editorial Material，,卷期：2010年19-8] Type 2 diabetes mellitus is associated with increased risk of malignancy (mainly cancer of the pancreas, breast, colon, endometrium and bladder). In addition, there is evidence that antidiabetic medication may itself aff... New inhibitors of the mammalian target of rapamycin signaling pathway for cancer [作者：Albert, S; Serova, M; Dreyer, C; Sablin, MP; Faivre, S; Raymond, E,期刊：Expert opinion on investigational drugs, 页码：919-930 , 文章类型： Review，,卷期：2010年19-8] Importance of the field: Contrasting with the broad activation of the PI3K/AKT/mammalian target of rapamycin (mTOR) survival pathway in most cancer, activity of rapalogues appears to be restricted to a few tumor types. A... New NS5B polymerase inhibitors for hepatitis C [作者：Legrand-Abravanel, F; Nicot, F; Izopet, J,期刊：Expert opinion on investigational drugs, 页码：963-975 , 文章类型： Review，,卷期：2010年19-8] Importance of the field: The current treatment of chronic hepatitis C based on the combination of pegylated interferon and ribavirin is effective in only 50% of patients. Specific targeted antiviral therapies represent a... Preclinical evidence of new opioid modulators for the treatment of addiction [作者：Rodriguez-Arias, M; Aguilar, MA; Manzanedo, C; Minarro, J,期刊：Expert opinion on investigational drugs, 页码：977-994 , 文章类型： Review，,卷期：2010年19-8] Importance of the field: Addiction to opiates is one of the most severe forms of substance dependence, and despite a variety of pharmacological approaches to treat it, relapse is observed in a high percentage of subjects... DP2 receptor antagonists in development [作者：Norman, P,期刊：Expert opinion on investigational drugs, 页码：947-961 , 文章类型： Review，,卷期：2010年19-8] Importance of the field: In asthmatic lung, allergen challenge leads to the production of large quantities of (prostaglandin D-2) PGD(2) which both contracts human airway tissue and stimulates an inflammatory response. T... Thymic carcinoma: current and future therapeutic interventions [作者：Weiss, GJ,期刊：Expert opinion on investigational drugs, 页码：1007-1016 , 文章类型： Review，,卷期：2010年19-8] Importance of the field: Since first reported just over 30 years ago, some progress has been made in our understanding of thymic cancer - an extremely rare cancer - and how to treat it. However, we are far from the ultim... Fixed-dose combination therapy for type 2 diabetes: sitagliptin plus pioglitazone [作者：Bailey, CJ; Green, BD; Flatt, PR,期刊：Expert opinion on investigational drugs, 页码：1017-1025 , 文章类型： Editorial Material，,卷期：2010年19-8] Importance of the field: Type 2 diabetes is typically associated with insulin resistance and dysfunction of insulin-secreting pancreatic beta-cells. Addressing these defects often requires therapy with a combination of d... Investigational anabolic therapies for osteoporosis [作者：Trivedi, R; Goswami, R; Chattopadhyay, N,期刊：Expert opinion on investigational drugs, 页码：995-1005 , 文章类型： Review，,卷期：2010年19-8] Importance of the field: Anabolic therapy, or stimulating the function of bone-forming osteoblasts, is the preferred pharmacological intervention for osteoporosis. Areas covered in this review: We reviewed bone anabolic ...