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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共15条记录   A nuclear glutathione cycle within the cell cycle [作者：Vivancos, PD; Wolff, T; Markovic, J; Pallardo, FV; Foyer, CH,期刊：Biochemical Journal, 页码：169-178 , 文章类型： Review，,卷期：2010年431-Part 2] The complex antioxidant network of plant and animal cells has the thiol tripeptide GSH at its centre to buffer ROS (reactive oxygen species) and facilitate cellular redox signalling which controls growth. development and... Human INO80 chromatin-remodelling complex contributes to DNA double-strand break repair via the expression of Rad54B and XRCC3 genes [作者：Park, EJ; Hur, SK; Kwon, J,期刊：Biochemical Journal, 页码：179-187 , 文章类型： Article，,卷期：2010年431-Part 2] Recent studies have shown that the SWI/SNF family of ATP-dependent chromatin-remodelling complexes play Important roles in DNA repair as well as in transcription. The INO80 complex, the most recently described member of ... Characterization of the role of dendritic cells in prion transfer to primary neurons [作者：Langevin, C; Gousset, K; Costanzo, M; Goff, ORL; Zurzolo, C,期刊：Biochemical Journal, 页码：189-198 , 文章类型： Article，,卷期：2010年431-Part 2] TSEs (transmissible spongiform encephalopathies) are neuro-degenerative diseases caused by pathogenic isoforms (PrPSc) of the host-encoded PrPc (cellular prion protein). After consumption of contaminated food. PrPSc depo... Domain structure elucidation of human decorin glycosaminoglycans [作者：Laremore, TN; Ly, M; Zhang, ZQ; Solakyildirim, K; McCallum, SA; Owens, RT; Linhardt, RJ,期刊：Biochemical Journal, 页码：199-205 , 文章类型： Article，,卷期：2010年431-Part 2] The structure of the GAG (glycosaminoglycan) chain of recombinantly expressed decorin proteoglycan was examined using a combination of intact-chain analysis and domain compositional analysis The GAG had a number-average ... Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner [作者：Strotmeier, J; Leet, K; Volker, AK; Mahrhold, S; Zong, YN; Zeiser, J; Zhou, J; Pich, A; Bigalke, H; Binz, T; Rummel, A; Jin, RS,期刊：Biochemical Journal, 页码：207-216 , 文章类型： Article，,卷期：2010年431-Part 2] The extraordinarily high toxicity of botulinum neurotoxins primarily results from their specific binding and uptake into neurons At motor neurons, the seven BoNT (botulinum neurotoxin) serotypes A-G inhibit acetylcholine... The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein [作者：Ovens, MJ; Manoharan, C; Wilson, MC; Murray, CM; Halestrap, AP,期刊：Biochemical Journal, 页码：217-225 , 文章类型： Article，,卷期：2010年431-Part 2] In mammalian cells. MCTs (monocarboxylate transporters) require association with an ancillary protein to enable plasma membrane expression of the active transporter. Basigin is the preferred binding partner for MCTI. MCT... Key motifs in EBV (Epstein-Barr virus)-encoded protein kinase for phosphorylation activity and nuclear localization [作者：Gershburg, S; Murphy, L; Marschall, M; Gershburg, E,期刊：Biochemical Journal, 页码：227-235 , 文章类型： Article，,卷期：2010年431-Part 2] A sole EBV (Epstein-Barr virus)-encoded protein kinase (EBV-PK) (the BGLF4 eerie product) plays important roles in viral infection. Although a number of targets of this protein have been identified, the kinase itself rem... HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5 '-phosphatase [作者：Preumont, A; Rzem, R; Vertommen, D; Van Schaftingen, E,期刊：Biochemical Journal, 页码：237-244 , 文章类型： Article，,卷期：2010年431-Part 2] Pseudouridine. the fifth-most abundant nucleoside in RNA, is not metabolized in mammals. but is excreted intact in urine The purpose of the present work was to search for an enzyme that would dephosphorylate pseudouridin... Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1) [作者：Pearce, LR; Alton, GR; Richter, DT; Kath, JC; Lingardo, L; Chapman, J; Hwang, C; Alessi, DR,期刊：Biochemical Journal, 页码：245-255 , 文章类型： Article，,卷期：2010年431-Part 2] S6K1 (p70 ribosomal S6 kinase 1) is activated by insulin and growth factors via the PI3K (phosphoinositide 3-kinase) and mTOR (mammalian target of rapamycin) signalling pathways S6K1 regulates numerous processes. such as... Cadmium regulates copper homoeostasis by inhibiting the activity of Mac1, a transcriptional activator of the copper regulon, in Saccharomyces cerevisiae [作者：Heo, DH; Baek, IJ; Kang, HJ; Kim, JH; Chang, M; Jeong, MY; Kim, TH; Choi, ID; Yun, CW,期刊：Biochemical Journal, 页码：257-265 , 文章类型： Article，,卷期：2010年431-Part 2] Cadmium is a toxic metal and the mechanism of its toxicity has been studied in various model systems from bacteria to mammals. We employed Saccharomyces cerevisiae as a model system to study cadmium toxicity at the molec... Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3) [作者：Mouton, V; Toussaint, L; Vertommen, D; Gueuning, MA; Maisin, L; Havaux, X; Sanchez-Canedo, C; Bertrand, L; Dequiedt, F; Hemmings, BA; Hue, L; Rider, MH,期刊：Biochemical Journal, 页码：267-275 , 文章类型： Article，,卷期：2010年431-Part 2] On the basis of transfection experiments using a dominant-negative approach. our previous studies suggested that PKB (protein kinase B) was not involved in heart PFK-2 (6-phosphofructo2-kinase) activation by insulin. The... Epidermal growth factor down-regulates the expression of human hepatic stimulator substance via CCAAT/enhancer-binding protein beta in HepG2 cells [作者：Dung, LY; Sun, GY; Jiang, LA; Shao, L; Hu, Y; Jiang, Y; Wang, YT; An, W,期刊：Biochemical Journal, 页码：277-287 , 文章类型： Article，,卷期：2010年431-Part 2] MASS (human hepatic stimulator substance), acting as a hepatotrophic growth factor, promotes liver regeneration However. the regulatory mechanisms for hHSS transcription are still poorly understood. In the present study,... Molecular determination of selectivity of the site 3 modulator (BmK I) to sodium channels in the CNS: a clue to the importance of Na(v)1.6 in BmK I-induced neuronal hyperexcitability [作者：He, HQ; Liu, ZR; Dong, BQ; Zhou, JJ; Zhu, HY; Ji, YH,期刊：Biochemical Journal, 页码：289-298 , 文章类型： Article，,卷期：2010年431-Part 2] BmK I. a site-3-specific modulator of VGSCs (voltage-gated sodium channels) from the Chinese scorpion Blain's martens' Karsch. can induce spontaneous nociception and hyperalgesia and generate epileptiform responses in ra... Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy [作者：Valenti, D; Tullo, A; Caratozzolo, MF; Merafina, RS; Scartezzini, P; Marra, E; Vacca, RA,期刊：Biochemical Journal, 页码：299-310 , 文章类型： Article，,卷期：2010年431-Part 2] A central role for mitochondrial dysfunction has been proposed in the pathogenesis of DS (Down's syndrome). a multifactorial disorder caused by trisomy of human chromosome 21. To explore whether and how abnormalities in ... Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle [作者：Vichaiwong, K; Purohit, S; An, D; Toyoda, T; Jessen, N; Hirshman, MF; Goodyear, LJ,期刊：Biochemical Journal, 页码：311-320 , 文章类型： Article，,卷期：2010年431-Part 2] TBC1D1 (tre-2/USP6, BUB2, cdc16 domain family member 1) is a Rab-GAP (GTPase-actvating protein) that is highly expressed in skeletal muscle, but little is known about TBC1D1 regulation and function. We studied TBC1D1 pho...