- N-4-Phenyl-substituted 2-acetylpyridine thiosemicarbazones: Cytotoxicity against human tumor cells, structure-activity relationship studies and investigation on the mechanism of action
[作者:SOARES MARCELLA A; LESSA JOSANE A; MENDES ISOLDA C; DA SILVA JEFERSON G; DOS SANTOS RAQUEL G; SALUM LIVIA B; DAGHESTANI HIKMAT; ANDRICOPULO ADRIANO D; DAY BILLY W; VOGT ANDREAS; PESQUERO JORGE L; ROCHA WILLIAN R; BERALDO HELOISA,期刊:Bioorganic & Medicinal Chemistry, 页码:3396-3409 , 文章类型: Article,,卷期:2012年20-11]
- N-4-Phenyl 2-acetylpyridine thiosemicarbazone (H2Ac4Ph; N-(phenyl)-2-(1-(pyridin-2-yl)ethylidene) hydrazinecarbothioamide) and its N-4-ortho-, -meta- and -para-fluorophenyl (H2Ac4oFPh, H2Ac4mFPh, H2Ac4pFPh), N-4-ortho-, ...
- Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives
[作者:BARROS FRANCISCO W A; SILVA TERESINHA GONCALVES; DA ROCHA PITTA MARINA GALDINO; BEZERRA DANIEL P; COSTALOTUFO LETICIA V; DE MORAES MANOEL ODORICO; PESSOA CLAUDIA; DE MOURA MARIA ALINE F B; DE ABREU FABIANE C; ALVES DE LIMA MARIA DO CARMO; GALDINO SUELY LINS; PITTA IVAN DA ROCHA; GOULART MARILIA O F,期刊:Bioorganic & Medicinal Chemistry, 页码:3533-3539 , 文章类型: Article,,卷期:2012年20-11]
- Although their exact role in controlling tumour growth and apoptosis in humans remains undefined, acridine and thiazolidine compounds have been shown to act as tumour suppressors in most cancers. Based on this finding, a...
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