- Paradoxical and Bidirectional Drug Effects
[作者:Smith, SW; Hauben, M; Aronson, JK,期刊:Drug safety, 页码:173-189 , 文章类型: Review,,卷期:2012年35-3]
- A paradoxical drug reaction constitutes an outcome that is opposite from the outcome that would be expected from the drug's known actions. There are three types: 1. A paradoxical response in a condition for which the dru...
- Oral Contraceptives and Venous Thromboembolism A Systematic Review and Meta-Analysis
[作者:Manzoli, L; De Vito, C; Marzuillo, C; Boccia, A; Villari, P,期刊:Drug safety, 页码:191-205 , 文章类型: Review,,卷期:2012年35-3]
- Background: An association between oral contraceptive (OC) use and venous thromboembolism (VTE) has long been recognized. However, no summary estimates of the increase in VTE risk associated with OC use have been availab...
- The Safety of an Adenosine A(1)-Receptor Antagonist, Rolofylline, in Patients with Acute Heart Failure and Renal Impairment Findings from PROTECT
[作者:Teerlink, JR; Iragui, VJ; Mohr, JP; Carson, PE; Hauptman, PJ; Lovett, DH; Miller, AB; Pina, IL; Thomson, S; Varosy, PD; Zile, MR; Cleland, JGF; Givertz, MM; Metra, M; Ponikowski, P; Voors, AA; Davison, BA; Cotter, G; Wolko, D; DeLucca, P; Salerno, CM; Mansoor, GA; Dittrich, H; O'Connor, CM; Massi, BM,期刊:Drug safety, 页码:233-244 , 文章类型: Article,,卷期:2012年35-3]
- Background: Adenosine exerts actions in multiple organ systems, and adenosine receptors are a therapeutic target in many development programmes. Objective: The aim of this analysis was to evaluate the safety of rolofylli...
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