- Emerging Opportunities and Concerns for Drug Discovery at Serotonin 5-5-HT2B Receptors
[作者:Brea, J; Castro-Palomino, J; Yeste, S; Cubero, E; Parraga, A; Dominguez, E; Loza, MI,期刊:Current Topics in Medicinal Chemistry, 页码:493-503 , 文章类型: Review,,卷期:2010年10-5]
- 5-HT2B receptors have been reported to play an important role at cardiac, intestinal and central levels, as well as in bone marrow formation and growth. In the last decade, 5-HT2B receptors have also gained much attentio...
- The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium
[作者:Cappelli, A; Butini, S; Brizzi, A; Gemma, S; Valenti, S; Giuliani, G; Anzini, M; Mennuni, L; Campiani, G; Brizzi, V; Vomero, S,期刊:Current Topics in Medicinal Chemistry, 页码:504-526 , 文章类型: Review,,卷期:2010年10-5]
- The 5-HT3 receptor (5-HT3R) occupies a special place among the serotonin receptor subtypes because it has been shown to be a ligand-gated ion channel, which is involved in a number of physiological functions and importan...
- Review of 5-HT4R Ligands: State of Art and Clinical Applications
[作者:Bureau, R; Boulouard, M; Dauphin, F; Lezoualc'h, F; Rault, S,期刊:Current Topics in Medicinal Chemistry, 页码:527-553 , 文章类型: Review,,卷期:2010年10-5]
- This article reviews the medicinal implications of 5-HT4R in the peripheral and central nervous systems, based on data from two hundred bibliographic references. An exhaustive compilation of molecules reported to be anta...
- Medicinal Chemistry of 5-HT5A Receptor Ligands: A Receptor Subtype with Unique Therapeutical Potential
[作者:Volk, B; Nagy, BJ; Vas, S; Kostyalik, D; Simig, G; Bagdy, G,期刊:Current Topics in Medicinal Chemistry, 页码:554-578 , 文章类型: Review,,卷期:2010年10-5]
- Although the 5-HT5 receptor subfamily was discovered more than 15 years ago, it is unambiguously the least known 5-HT receptor subtype. The G(i)/G(0)-mediated signal transduction and its intensive presence in raphe and o...
- The Medicinal Chemistry of 5-HT6 Receptor Ligands with a Focus on Arylsulfonyltryptamine Analogs
[作者:Glennon, RA; Siripurapu, U; Roth, BL; Kolanos, R; Bondarev, ML; Sikazwe, D; Lee, M; Dukat, M,期刊:Current Topics in Medicinal Chemistry, 页码:579-595 , 文章类型: Review,,卷期:2010年10-5]
- Arylsulfonyl analogs of aminopyrimidines (e. g. Ro 04-6790; 2), aminopyridines (e. g. Ro 63-0563; 3), 1-phenylpiperazines (e. g. SB-271046; 4), and tryptamines (e. g. MS-245; 5) were described as the first examples of se...
- Exploration of Structure-Activity Relationships for Dual Serotonin Transporter Reuptake Inhibitors-Histamine H-3 Receptor Antagonists
[作者:Stocking, EM; Letavic, MA; Bonaventure, P; Carruthers, NI,期刊:Current Topics in Medicinal Chemistry, 页码:596-616 , 文章类型: Review,,卷期:2010年10-5]
- Depression is a major health issue, which is routinely treated with selective serotonin reuptake inhibitors. However, although these agents display a favorable effect on mood, they often fail to improve conditions that a...
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