Expert opinion on investigational drugs————————个性化文献订阅—

Pitfalls of clinical trials on pharmacological treatment for obstructive sleep apnoea: future directions
[作者：Kohler, M; Stradling, JR,期刊：Expert opinion on investigational drugs, 页码：1033-1037 , 文章类型： Editorial Material，,卷期：2011年20-8]
The standard treatment for obstructive sleep apnoea (OSA) is continuous positive airway pressure (CPAP). Depending on selection criteria and quality of care, up to 50% of patients with OSA do not tolerate CPAP. For patie...

An investigation of the effect of sorafenib on tumour growth and recurrence after liver cancer resection in nude mice independent of phosphorylated extracellular signal-regulated kinase levels
[作者：Wang, Z; Hu, J; Qiu, SJ; Huang, XW; Dai, Z; Tan, CJ; Zhou, J; Fan, J,期刊：Expert opinion on investigational drugs, 页码：1039-1045 , 文章类型： Article，,卷期：2011年20-8]
Objective: The goal of this study is to investigate the effects of sorafenib on tumor growth, recurrence and metastasis after curative resection of liver cancer.Research methods: SMMC-7721 and HCCLM3 liver tumors, each w...

Novel opioid antagonists for opioid-induced bowel dysfunction
[作者：Diego, L; Atayee, R; Helmons, P; Hsiao, G; von Gunten, CF,期刊：Expert opinion on investigational drugs, 页码：1047-1056 , 文章类型： Review，,卷期：2011年20-8]
Introduction: Adverse effects frequently limit the therapeutic benefits of opioid analgesics. Gastrointestinal adverse effects are common, burdensome, and can compromise the quality of life. It is estimated that up to 81...

New approaches to the treatment of nephropathy in diabetes
[作者：Thomas, MC; Groop, PH,期刊：Expert opinion on investigational drugs, 页码：1057-1071 , 文章类型： Review，,卷期：2011年20-8]
Introduction: In individuals with diabetes, the presence and severity of kidney disease adversely affects their well-being, significantly contributes to burden of morbidity and increases their risk of a premature death. ...

Opioid modulators for alcohol dependence
[作者：Hillemacher, T; Heberlein, A; Muschler, MAN; Bleich, S; Frieling, H,期刊：Expert opinion on investigational drugs, 页码：1073-1086 , 文章类型： Review，,卷期：2011年20-8]
Introduction: Studies have shown that opioid antagonists like naltrexone are efficient in reducing heavy drinking. The neurobiological mechanism by which opioid modulators affect drinking behavior is based on the strong ...

Investigational drugs in thrombotic thrombocytopenic purpura
[作者：Noris, P; Balduini, CL,期刊：Expert opinion on investigational drugs, 页码：1087-1098 , 文章类型： Review，,卷期：2011年20-8]
Introduction: Familial and acquired, idiopathic, thrombotic thrombocytopenic purpura (TTP) are life-threatening thrombotic microangiopathies characterized by thrombocytopenia and microangiopathic hemolytic anemia derivin...

Tumor treating fields: concept, evidence and future
[作者：Pless, M; Weinberg, U,期刊：Expert opinion on investigational drugs, 页码：1099-1106 , 文章类型： Review，,卷期：2011年20-8]
Introduction: Local control is fundamental, both for the curative as well as the palliative treatment of cancer. Tumor treating fields (TTFields) are low intensity (1 - 2 V/cm), intermediate frequency (100 - 200 kHz) alt...

Triple reuptake inhibitors for treating subtypes of major depressive disorder: the monoamine hypothesis revisited
[作者：Prins, J; Olivier, B; Korte, SM,期刊：Expert opinion on investigational drugs, 页码：1107-1130 , 文章类型： Review，,卷期：2011年20-8]
Introduction: Major depression is one of the most prevalent forms of mental illnesses and is among the leading causes of disability, affecting about 121 million people worldwide. Approximately 30% of patients fail to res...

Investigational antibody drug conjugates for solid tumors
[作者：Sapra, P; Hooper, AT; O'Donnell, CJ; Gerber, HP,期刊：Expert opinion on investigational drugs, 页码：1131-1149 , 文章类型： Review，,卷期：2011年20-8]
Introduction: Despite the progress made in the past 20 years in understanding the molecular events leading to the formation of cancer, the success of targeted antitumor agents in solid tumors has lagged behind the scient...

Romidepsin: a novel histone deacetylase inhibitor for cancer
[作者：Bertino, EM; Otterson, GA,期刊：Expert opinion on investigational drugs, 页码：1151-1158 , 文章类型： Article，,卷期：2011年20-8]
Introduction: Romidepsin is a novel histone deacetylase (HDAC) inhibitor, with a recent approval for treatment of cutaneous T-cell lymphoma (CTCL). HDAC inhibitors represent a novel approach to anti-tumor therapy. In con...

A potential role of ruxolitinib in leukemia
[作者：Naqvi, K; Verstovsek, S; Kantarjian, H; Ravandi, F,期刊：Expert opinion on investigational drugs, 页码：1159-1166 , 文章类型： Article，,卷期：2011年20-8]
Introduction: An increased understanding of cellular signaling pathways, like the JAK-STAT pathway, and the identification of the JAK2 V617F mutation in the classic Philadelphia chromosome-negative myeloproliferative neo...

Enzastaurin hydrochloride for lymphoma: reassessing the results of clinical trials in light of recent advances in the biology of B-cell malignancies
[作者：Ysebaert, L; Morschhauser, F,期刊：Expert opinion on investigational drugs, 页码：1167-1174 , 文章类型： Article，,卷期：2011年20-8]
Introduction: The B-cell receptor (BCR) is critical for the development and persistence of B-cell non-Hodgkin lymphoma (B-NHL). Protein kinase C-beta (PKC-beta) has been identified as one of the key signaling hubs downst...