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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Restriction of retinoic acid activity by Cyp26b1 is required for proper timing and patterning of osteogenesis during zebrafish development [作者：Laue, K; Janicke, M; Plaster, N; Sonntag, C; Hammerschmidt, M,期刊：Development, 页码：3775-3787 , 文章类型： Article，,卷期：2008年135-22] Skeletal syndromes are among the most common birth defects. Vertebrate skeletogenesis involves two major cell types: cartilage-forming chondrocytes and bone-forming osteoblasts. In vitro, both are under the control of re... Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential [作者：Thomas, NA; Koudijs, M; van Eeden, FJM; Joyner, AL; Yelon, D,期刊：Development, 页码：3789-3799 , 文章类型： Article，,卷期：2008年135-22] Elucidation of the complete roster of signals required for myocardial specification is crucial to the future of cardiac regenerative medicine. Prior studies have implicated the Hedgehog (Hh) signaling pathway in the regu... BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway [作者：Kamiya, N; Ye, L; Kobayashi, T; Mochida, Y; Yamauchi, M; Kronenberg, HM; Feng, JQ; Mishina, Y,期刊：Development, 页码：3801-3811 , 文章类型： Article，,卷期：2008年135-22] Bone morphogenetic proteins (BMPs) are known to induce ectopic bone. However, it is largely unknown how BMP signaling in osteoblasts directly regulates endogenous bone. This study investigated the mechanism by which BMP ... Regulated adhesion as a driving force of gastrulation movements [作者：Hammerschmidt, M; Wedlich, D,期刊：Development, 页码：3625-3641 , 文章类型： Review，,卷期：2008年135-22] Recent data have reinforced the fundamental role of regulated cell adhesion as a force that drives morphogenesis during gastrulation. As we discuss, cell adhesion is required for all modes of gastrulation movements in al... Pioneer longitudinal axons navigate using floor plate and Slit/Robo signals [作者：Farmer, WT; Altick, AL; Nural, HF; Dugan, JP; Kidd, T; Charron, F; Mastick, GS,期刊：Development, 页码：3643-3653 , 文章类型： Article，,卷期：2008年135-22] Longitudinal axons transmit all signals between the brain and spinal cord. Their axon tracts through the brain stem are established by a simple set of pioneer axons with precise trajectories parallel to the floor plate. ... The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development [作者：Kazanskaya, O; Ohkawara, B; Heroult, M; Wu, W; Maltry, N; Augustin, HG; Niehrs, C,期刊：Development, 页码：3655-3664 , 文章类型： Article，,卷期：2008年135-22] The vertebrate embryonic vasculature develops from angioblasts, which are specified from mesodermal precursors and develop in close association with blood cells. The signals that regulate embryonic vasculogenesis and ang... MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4-and PAR-1-dependent phosphorylation [作者：Tenlen, JR; Molk, JN; London, N; Page, BD; Priess, JR,期刊：Development, 页码：3665-3675 , 文章类型： Article，,卷期：2008年135-22] Anteroposterior polarity in early C. elegans embryos is required for the specification of somatic and germline lineages, and is initiated by a sperm-induced reorganization of the cortical cytoskeleton and PAR polarity pr... Mobilisation of Ca2+ stores and flagellar regulation in human sperm by S-nitrosylation: a role for NO synthesised in the female reproductive tract [作者：Machado-Oliveira, G; Lefievre, L; Ford, C; Herrero, MB; Barratt, C; Connolly, TJ; Nash, K; Morales-Garcia, A; Kirkman-Brown, J; Publicover, S,期刊：Development, 页码：3677-3686 , 文章类型： Article，,卷期：2008年135-22] Generation of NO by nitric oxide synthase (NOS) is implicated in gamete interaction and fertilisation. Exposure of human spermatozoa to NO donors caused mobilisation of stored Ca2+ by a mechanism that did not require act... Wnt signaling determines ventral spinal cord cell fates in a time-dependent manner [作者：Yu, WY; McDonnell, K; Taketo, MM; Bai, CB,期刊：Development, 页码：3687-3696 , 文章类型： Article，,卷期：2008年135-22] The identity of distinct cell types in the ventral neural tube is generally believed to be specified by sonic hedgehog (Shh) in a concentration-dependent manner. However, recent studies have questioned whether Shh is the... alpha-Endosulfine is a conserved protein required for oocyte meiotic maturation in Drosophila [作者：Von Stetina, JR; Tranguch, S; Dey, SK; Lee, LA; Cha, B; Drummond-Barbosa, D,期刊：Development, 页码：3697-3706 , 文章类型： Article，,卷期：2008年135-22] Meiosis is coupled to gamete development and must be well regulated to prevent aneuploidy. During meiotic maturation, Drosophila oocytes progress from prophase I to metaphase I. The molecular factors controlling meiotic ... The development of motor coordination in Drosophila embryos [作者：Crisp, S; Evers, JF; Fiala, A; Bate, M,期刊：Development, 页码：3707-3717 , 文章类型： Article，,卷期：2008年135-22] We used non-invasive muscle imaging to study the onset of motor activity and emergence of coordinated movement in Drosophila embryos. Earliest movements are myogenic, and neurally controlled muscle contractions first app... Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation [作者：Cha, SW; Tadjuidje, E; Tao, Q; Wylie, C; Heasman, J,期刊：Development, 页码：3719-3729 , 文章类型： Article，,卷期：2008年135-22] Wnt signaling in development and adult tissue homeostasis requires tight regulation to prevent patterning abnormalities and tumor formation. Here, we show that the maternal Wnt antagonist Dkk1 downregulates both the cano... Ovarian development in mice requires the GATA4-FOG2 transcription complex [作者：Manuylov, NL; Smagulova, FO; Leach, L; Tevosian, SG,期刊：Development, 页码：3731-3743 , 文章类型： Article，,卷期：2008年135-22] We have demonstrated previously that mammalian sexual differentiation requires both the GATA4 and FOG2 transcriptional regulators to assemble the functioning testis. Here we have determined that the sexual development of... Notch signaling maintains Leydig progenitor cells in the mouse testis [作者：Tang, H; Brennan, J; Karl, J; Hamada, Y; Raetzman, L; Capel, B,期刊：Development, 页码：3745-3753 , 文章类型： Article，,卷期：2008年135-22] During testis development, fetal Leydig cells increase their population from a pool of progenitor cells rather than from proliferation of a differentiated cell population. However, the mechanism that regulates Leydig ste... Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis [作者：Kim, YH; Hu, HQ; Guevara-Gallardo, S; Lam, MTY; Fong, SY; Wang, RA,期刊：Development, 页码：3755-3764 , 文章类型： Article，,卷期：2008年135-22] A mutual coordination of size between developing arteries and veins is essential for establishing proper connections between these vessels and, ultimately, a functional vasculature; however, the cellular and molecular re... Retinoic acid and Cyp26b1 are critical regulators of osteogenesis in the axial skeleton [作者：Spoorendonk, KM; Peterson-Maduro, J; Renn, J; Trowe, T; Kranenbarg, S; Winkler, C; Schulte-Merker, S,期刊：Development, 页码：3765-3774 , 文章类型： Article，,卷期：2008年135-22] Retinoic acid (RA) plays important roles in diverse biological processes ranging from germ cell specification to limb patterning. RA ultimately exerts its effect in the nucleus, but how RA levels are being generated and ...