- A novel nested liposome drug delivery vehicle capable of ultrasound triggered release of its payload
[作者:Ibsen, S; Benchimol, M; Simberg, D; Schutt, C; Steiner, J; Esener, S,期刊:Journal of controlled release, 页码:358-366 , 文章类型: Article,,卷期:2011年155-3]
- The use of focused ultrasound can be an effective method to locally highlight tumor tissue and specifically trigger the activation of echogenic drug delivery vehicles in an effort to reduce systemic chemotherapy side eff...
- Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; unique intracellular disintegration of SMA micelles
[作者:Nakamura, H; Fang, J; Gahininath, B; Tsukigawa, K; Maeda, H,期刊:Journal of controlled release, 页码:367-375 , 文章类型: Article,,卷期:2011年155-3]
- SMA-ZnPP and PEG-ZnPP are micellar drugs, encapsulating zinc protoporphyrin IX (ZnPP) with styrene maleic acid copolymer (SMA) and covalent conjugate of ZnPP with polyethylene glycol (PEG) respectively. Their intracellul...
- A delivery system to avoid self-aggregation and to improve in vitro and in vivo skin delivery of a phthalocyanine derivative used in the photodynamic therapy
[作者:Rossetti, FC; Lopes, LB; Carollo, ARH; Thomazini, JA; Tedesco, AC; Bentley, MVLB,期刊:Journal of controlled release, 页码:400-408 , 文章类型: Article,,卷期:2011年155-3]
- The hydrophilic character and aggregation phenomena exhibited by the photosensitizer zinc phthalocyanine tetrasulfonate (ZnPcSO(4)) make it difficult for this compound to penetrate the skin, and reduce the compound's pho...
- Understanding controlled drug release from mesoporous silicates: Theory and experiment
[作者:Ukmar, T; Maver, U; Planinsek, O; Kaucic, V; Gaberscek, M; Godec, A,期刊:Journal of controlled release, 页码:409-417 , 文章类型: Article,,卷期:2011年155-3]
- Based on the results of carefully designed experiments upgraded with appropriate theoretical modeling, we present clear evidence that the release curves from mesoporous materials are significantly affected by drug-matrix...
- Development of microRNA-145 for therapeutic application in breast cancer
[作者:Kim, SJ; Oh, JS; Shin, JY; Lee, KD; Sung, KW; Nam, SJ; Chun, KH,期刊:Journal of controlled release, 页码:427-434 , 文章类型: Article,,卷期:2011年155-3]
- MicroRNAs, small non-coding RNAs, are key regulators of tumorigenesis and cancer metastasis through inhibition of gene expression. Therefore, there is increasing interest in developing anti-cancer therapies using microRN...
- Targeted chemoimmunotherapy using drug-loaded aptamer-dendrimer bioconjugates
[作者:Lee, IH; An, S; Yu, MK; Kwon, HK; Im, SH; Jon, S,期刊:Journal of controlled release, 页码:435-441 , 文章类型: Article,,卷期:2011年155-3]
- We reported an innovative, targeted chemoimmuno drug-delivery system. Although chemoimmunotherapy, as an alternative to or in combination with conventional therapeutic systems, has been in the forefront of recent oncolog...
- Ultrasound-mediated intracellular drug delivery using microbubbles and temperature-sensitive liposomes
[作者:Yudina, A; de Smet, M; Lepetit-Coiffe, M; Langereis, S; Van Ruijssevelt, L; Smirnov, P; Bouchaud, V; Voisin, P; Grull, H; Moonen, CTW,期刊:Journal of controlled release, 页码:442-448 , 文章类型: Article,,卷期:2011年155-3]
- A novel two-step protocol for intracellular drug delivery has been evaluated in vitro. As a first step TO-PRO-3 (a cell-impermeable dye that displays a strong fluorescence enhancement upon binding to nucleic acids) encap...
- Disulfide crosslinked polyion complex micelles encapsulating dendrimer phthalocyanine directed to improved efficiency of photodynamic therapy
[作者:Herlambang, S; Kumagai, M; Nomoto, T; Horie, S; Fukushima, S; Oba, M; Miyazaki, K; Morimoto, Y; Nishiyama, N; Kataoka, K,期刊:Journal of controlled release, 页码:449-457 , 文章类型: Article,,卷期:2011年155-3]
- Dendrimer phthalocyanine (DPc)-loaded polyion complex micelle (DPc/m) has been developed as photosensitizer (PS) formulation in photodynamic therapy (PDT). Incorporation of DPc into the micelle showed significant enhance...
- Dendrimer phthalocyanine-encapsulated polymeric micelle-mediated photochemical internalization extends the efficacy of photodynamic therapy and overcomes drug-resistance in vivo
[作者:Lu, HL; Syu, WJ; Nishiyama, N; Kataoka, K; Lai, PS,期刊:Journal of controlled release, 页码:458-464 , 文章类型: Article,,卷期:2011年155-3]
- Clinically, the efficacy of chemotherapeutic agents can be dramatically reduced in cancer cells with multiple drug resistance (MDR). In doxorubicin-resistant breast cancer cells, drugs accumulate only within discrete cyt...
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