- Dry powder aerosols of polyethylenimine (PEI)-based gene vectors mediate efficient gene delivery to the lung
[作者:Pfeifer, C; Hasenpusch, G; Uezguen, S; Aneja, MK; Reinhardt, D; Kirch, J; Schneider, M; Claus, S; Friess, W; Rudolph, C,期刊:Journal of controlled release, 页码:69-76 , 文章类型: Article,,卷期:2011年154-1]
- Aerosol gene delivery holds great therapeutical potential for many inherited and acquired pulmonary diseases. The physical instability of aqueous suspensions of non-viral vector complexes is a major limitation for their ...
- Novel geometry type of nanocarriers mitigated the phagocytosis for drug delivery
[作者:Lin, SY; Hsu, WH; Lo, JM; Tsai, HC; Hsiue, GH,期刊:Journal of controlled release, 页码:84-92 , 文章类型: Article,,卷期:2011年154-1]
- Target geometry for mitigating phagocytosis has garnered considerable attention recently in the drug delivery field. This study examined nanoparticles (NPs) with same volume but different shapes, namely, spherical NPs (S...
- TRAIL and doxorubicin combination enhances anti-glioblastoma effect based on passive tumor targeting of liposomes
[作者:Guo, LR; Fan, L; Pang, ZQ; Ren, JF; Ren, YL; Li, JW; Chen, J; Wen, ZY; Jiang, XG,期刊:Journal of controlled release, 页码:93-102 , 文章类型: Article,,卷期:2011年154-1]
- Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a novel anticancer agent for glioblastoma multiforme (GBM). Some GBM cell lines, however, are relatively resistant to TRAIL Doxorubicin (DOX) can sensiti...
- Kinetics of transport of doxorubicin bound to nanoparticles across the blood-brain barrier
[作者:Wohlfart, S; Khalansky, AS; Gelperina, S; Begley, D; Kreuter, J,期刊:Journal of controlled release, 页码:103-107 , 文章类型: Article,,卷期:2011年154-1]
- Drug delivery to the brain is restricted due to the blood-brain barrier (BBB). Previously, it has been shown that surfactant-coated doxorubicin-loaded nanoparticles were successful in overcoming the BBB and were effectiv...
- Novel tocotrienol-entrapping vesicles can eradicate solid tumors after intravenous administration
[作者:Fu, JY; Zhang, W; Blatchford, DR; Tetley, L; McConnell, G; Dufes, C,期刊:Journal of controlled release, 页码:20-26 , 文章类型: Article,,卷期:2011年154-1]
- The therapeutic potential of tocotrienol, a vitamin E extract with anti-cancer properties, is hampered by its failure to specifically reach tumors after intravenous administration. In this work, we demonstrated that nove...
- Localized ultrasound enhances delivery of rapamycin from microbubbles to prevent smooth muscle proliferation
[作者:Phillips, LC; Klibanov, AL; Wamhoff, BR; Hossack, JA,期刊:Journal of controlled release, 页码:42-49 , 文章类型: Article,,卷期:2011年154-1]
- Microbubble contrast agents have been shown to enhance reagent delivery when activated by ultrasound. We hypothesized that ultrasound would enhance delivery of rapamycin, an antiproliferative agent, from the shell of mic...
- Maximum transepidermal flux for similar size phenolic compounds is enhanced by solvent uptake into the skin
[作者:Zhang, Q; Li, P; Roberts, MS,期刊:Journal of controlled release, 页码:50-57 , 文章类型: Article,,卷期:2011年154-1]
- In principle, the maximum skin flux of solutes should be unaffected by the vehicle, unless that vehicle affects the skin. We recently showed that the maximum epidermal flux for 10 similarly sized phenolic compounds, with...
- Microsecond thermal ablation of skin for transdermal drug delivery
[作者:Lee, JW; Gadiraju, P; Park, JH; Allen, MG; Prausnitz, MR,期刊:Journal of controlled release, 页码:58-68 , 文章类型: Article,,卷期:2011年154-1]
- Thermal ablation is a promising mechanism to increase permeability of the skin's outer barrier layer of stratum corneum while sparing deeper living tissues. In this study, finite element modeling predicted that the skin ...
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